DegronMD

Uniprot ID: Q7L2E3

Source protein: ATP-dependent RNA helicase DHX30

Source gene: DHX30

Class: DEG_APCC_DBOX_1

Location: 1153:1161

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8547

ASA_SCORE: 68.4778

COIL: 0.7097

CONS_SCORE: 0.3474

DSS_SCORE: 0.3329

HELIX: 0.274

FCONS_SCORE: 0.8087

RIG_SCORE: 0.7268

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1167Q	TCGA-DU-A5TT	LGG	TCGA	LRSELAALP	DEG_APCC_DBOX_1	0.1667
p.R1154C	TCGA-IB-7651	PAAD	TCGA	LRSELAALP	DEG_APCC_DBOX_1	0.8301
p.R1154C	ACH-002287	Colon/Colorectal Cancer	CCLE	LRSELAALP	DEG_APCC_DBOX_1	0.8301
p.R1154C	NCI-H630	large_intestine	COSMIC	LRSELAALP	DEG_APCC_DBOX_1	0.8301
p.R1151Q	SIDM01954	Colorectal Carcinoma	GDSC	LRSELAALP	DEG_APCC_DBOX_1	0.2778
p.E1166V	SIDM01450	Gastric Carcinoma	GDSC	LRSELAALP	DEG_APCC_DBOX_1	0.1944
p.E1166V	ACH-000898	Gastric Cancer	CCLE	LRSELAALP	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7L2E3	ATP-dependent RNA helicase DHX30	DEG_APCC_DBOX_1	1153:1161	LRSELAALP	APC,CDC20,FZR1	0.8547	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons