DegronMD

Uniprot ID: Q7L2E3

Source protein: ATP-dependent RNA helicase DHX30

Source gene: DHX30

Class: DEG_APCC_DBOX_1

Location: 1141:1149

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7189

ASA_SCORE: 33.7556

COIL: 0.0044

CONS_SCORE: 0.4829

DSS_SCORE: 0.1883

HELIX: 0.9952

FCONS_SCORE: 1.2079

RIG_SCORE: 0.7893

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1135M	TCGA-AA-A022	COAD	TCGA	LRRALGRMV	DEG_APCC_DBOX_1	0.1667
p.R1147C	TCGA-B5-A3FC	UCEC	TCGA	LRRALGRMV	DEG_APCC_DBOX_1	0.719
p.R1142W	TCGA-IB-7651	PAAD	TCGA	LRRALGRMV	DEG_APCC_DBOX_1	0.8634
p.R1133H	TCGA-XK-AAIW	PRAD	TCGA	LRRALGRMV	DEG_APCC_DBOX_1	0.1111
p.E1139Q	DO44564	LGG	ICGC	LRRALGRMV	DEG_APCC_DBOX_1	0.7222
p.A1145V	DO228138	PBCA	ICGC	LRRALGRMV	DEG_APCC_DBOX_1	0.6936
p.R1151Q	SIDM01954	Colorectal Carcinoma	GDSC	LRRALGRMV	DEG_APCC_DBOX_1	0.2778
p.R1143Q	ACH-000520	Ovarian Cancer	CCLE	LRRALGRMV	DEG_APCC_DBOX_1	0.6218
p.M1148L	ACH-000896	Bladder Cancer	CCLE	LRRALGRMV	DEG_APCC_DBOX_1	0.5999
p.M1148L	647-V	urinary_tract	COSMIC	LRRALGRMV	DEG_APCC_DBOX_1	0.5999

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7L2E3	ATP-dependent RNA helicase DHX30	DEG_APCC_DBOX_1	1141:1149	LRRALGRMV	APC,CDC20,FZR1	0.7189	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons