DegronMD

Uniprot ID: Q7L2E3

Source protein: ATP-dependent RNA helicase DHX30

Source gene: DHX30

Class: DEG_SCF_FBW7_1

Location: 31:38

E3 ligase: FBXW7

DEGRON score: 0.9749

ASA_SCORE: 73.9

COIL: 0.9083

CONS_SCORE: 0.296

DSS_SCORE: 0.596

HELIX: 0.0678

FCONS_SCORE: 0.9308

RIG_SCORE: 0.6104

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D45Y	TCGA-69-7974	LUAD	TCGA	VNPTPGGT	DEG_SCF_FBW7_1	0.1389
p.S43A	TCGA-AA-3675	COAD	TCGA	VNPTPGGT	DEG_SCF_FBW7_1	0.1944
p.L47F	TCGA-CA-6717	COAD	TCGA	VNPTPGGT	DEG_SCF_FBW7_1	0.0833
p.R44S	TCGA-D3-A2JP	SKCM	TCGA	VNPTPGGT	DEG_SCF_FBW7_1	0.1667
p.P22L	TCGA-DF-A2KS	UCEC	TCGA	VNPTPGGT	DEG_SCF_FBW7_1	0.0833
p.P22L	DO223285	UCEC	ICGC	VNPTPGGT	DEG_SCF_FBW7_1	0.0833
p.P22S	TCGA-EE-A2MU	SKCM	TCGA	VNPTPGGT	DEG_SCF_FBW7_1	0.0833
p.P22S	DO37436	SKCM	ICGC	VNPTPGGT	DEG_SCF_FBW7_1	0.0833
p.R24T	DO219033	BLCA	ICGC	VNPTPGGT	DEG_SCF_FBW7_1	0.1389
p.R25H	DO228430	BRCA	ICGC	VNPTPGGT	DEG_SCF_FBW7_1	0.1667
p.R25H	DO227979	COCA	ICGC	VNPTPGGT	DEG_SCF_FBW7_1	0.1667
p.P22H	DO233215	GACA	ICGC	VNPTPGGT	DEG_SCF_FBW7_1	0.0833
p.V36F	DO229006	LICA	ICGC	VNPTPGGT	DEG_SCF_FBW7_1	0.7068
p.K32E	DO44634	LICA	ICGC	VNPTPGGT	DEG_SCF_FBW7_1	0.7022
p.K32N	DO47743	STAD	ICGC	VNPTPGGT	DEG_SCF_FBW7_1	0.6918
p.L26I	SIDM02021	Esophageal Carcinoma	GDSC	VNPTPGGT	DEG_SCF_FBW7_1	0.1944
p.P24H	SIDM00683	Prostate Carcinoma	GDSC	VNPTPGGT	DEG_SCF_FBW7_1	0.1389
p.P24H	LNCaP-Clone-FGC	prostate	COSMIC	VNPTPGGT	DEG_SCF_FBW7_1	0.1389
p.P22A	SIDM00516	Melanoma	GDSC	VNPTPGGT	DEG_SCF_FBW7_1	0.0833
p.P22A	ACH-002166	Skin Cancer	CCLE	VNPTPGGT	DEG_SCF_FBW7_1	0.0833
p.P22A	MZ7-mel	skin	COSMIC	VNPTPGGT	DEG_SCF_FBW7_1	0.0833
p.T34A	SIDM00839	Colorectal Carcinoma	GDSC	VNPTPGGT	DEG_SCF_FBW7_1	0.7139
p.T34A	LoVo	large_intestine	COSMIC	VNPTPGGT	DEG_SCF_FBW7_1	0.7139
p.P23L	ACH-002059	Leukemia	CCLE	VNPTPGGT	DEG_SCF_FBW7_1	0.1111
p.P23L	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	VNPTPGGT	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7L2E3	ATP-dependent RNA helicase DHX30	DEG_SCF_FBW7_1	31:38	VNPTPGGT	FBXW7	0.9749	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons