DegronMD

Uniprot ID: Q6V0I7

Source protein: Protocadherin Fat 4

Source gene: FAT4

Class: DEG_SCF_TRCP1_1

Location: 2078:2083

E3 ligase: BTRC

DEGRON score: 0.9186

ASA_SCORE: 57.8167

COIL: 0.7827

CONS_SCORE: 0.6885

DSS_SCORE: 0.3944

HELIX: 0.0337

FCONS_SCORE: 1.2079

RIG_SCORE: 0.6911

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D2078A	TCGA-A5-A1OF	UCEC	TCGA	DSGPNS	DEG_SCF_TRCP1_1	0.7793
p.P2077T	TCGA-AA-A01V	COAD	TCGA	DSGPNS	DEG_SCF_TRCP1_1	0.3056
p.P2077R	TCGA-AA-A01V	COAD	TCGA	DSGPNS	DEG_SCF_TRCP1_1	0.3056
p.I2085T	TCGA-BS-A0UF	UCEC	TCGA	DSGPNS	DEG_SCF_TRCP1_1	0.2778
p.T2088I	TCGA-FJ-A3ZE	BLCA	TCGA	DSGPNS	DEG_SCF_TRCP1_1	0.1944
p.P2092L	TCGA-GN-A26A	SKCM	TCGA	DSGPNS	DEG_SCF_TRCP1_1	0.0833
p.R2090Q	DO222765	COCA	ICGC	DSGPNS	DEG_SCF_TRCP1_1	0.1389
p.V2077I	DO223058	ESCA	ICGC	DSGPNS	DEG_SCF_TRCP1_1	0.3056
p.V2077I	DO42057	UCEC	ICGC	DSGPNS	DEG_SCF_TRCP1_1	0.3056
p.R2090W	DO233041	GACA	ICGC	DSGPNS	DEG_SCF_TRCP1_1	0.1389
p.R2090W	DO52034	HNSC	ICGC	DSGPNS	DEG_SCF_TRCP1_1	0.1389
p.R2090W	DO48729	LGG	ICGC	DSGPNS	DEG_SCF_TRCP1_1	0.1389
p.R2090W	DO33368	PACA	ICGC	DSGPNS	DEG_SCF_TRCP1_1	0.1389
p.R2090W	EW-16	bone	COSMIC	DSGPNS	DEG_SCF_TRCP1_1	0.1389
p.R2090W	LAMA-84	haematopoietic_and_lymphoid_tissue	COSMIC	DSGPNS	DEG_SCF_TRCP1_1	0.1389
p.V2072L	DO229027	LICA	ICGC	DSGPNS	DEG_SCF_TRCP1_1	0.1667
p.G2093R	DO26240	LUAD	ICGC	DSGPNS	DEG_SCF_TRCP1_1	0.0556
p.F2081S	DO219139	LUSC	ICGC	DSGPNS	DEG_SCF_TRCP1_1	0.7982
p.E2086K	DO222775	MELA	ICGC	DSGPNS	DEG_SCF_TRCP1_1	0.25
p.E2086K	DO47665	SKCM	ICGC	DSGPNS	DEG_SCF_TRCP1_1	0.25
p.E2086K	DO47646	SKCM	ICGC	DSGPNS	DEG_SCF_TRCP1_1	0.25
p.P2074S	DO47419	SKCM	ICGC	DSGPNS	DEG_SCF_TRCP1_1	0.2222
p.P2074S	DO219487	SKCM	ICGC	DSGPNS	DEG_SCF_TRCP1_1	0.2222
p.P2074S	HCC2998	large_intestine	COSMIC	DSGPNS	DEG_SCF_TRCP1_1	0.2222
p.H2068N	DO43923	UCEC	ICGC	DSGPNS	DEG_SCF_TRCP1_1	0.0556
p.G2080S	SIDM01059	Melanoma	GDSC	DSGPNS	DEG_SCF_TRCP1_1	0.6993
p.G2080S	ACH-000915	Skin Cancer	CCLE	DSGPNS	DEG_SCF_TRCP1_1	0.6993
p.G2080S	IPC-298	skin	COSMIC	DSGPNS	DEG_SCF_TRCP1_1	0.6993
p.K2071R	SIDM01561	Melanoma	GDSC	DSGPNS	DEG_SCF_TRCP1_1	0.25
p.K2071R	ACH-000799	Skin Cancer	CCLE	DSGPNS	DEG_SCF_TRCP1_1	0.25
p.F2080L	GP5d	large_intestine	COSMIC	DSGPNS	DEG_SCF_TRCP1_1	0.6981

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGPNS

Degron related mutations and impact score

Drug responses associated with FAT4 mutations

All proteins holding degron of DSGPNS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6V0I7	Protocadherin Fat 4	DEG_SCF_TRCP1_1	2078:2083	DSGPNS	BTRC	0.9186	More...