DegronMD

Uniprot ID: Q9H1E3

Source protein: Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

Source gene: NUCKS1

Class: DEG_SCF_TRCP1_1

Location: 29:34

E3 ligase: BTRC

DEGRON score: 0.9912

ASA_SCORE: 80.15

COIL: 0.9665

CONS_SCORE: 0.7012

DSS_SCORE: 0.73

HELIX: 0.0197

FCONS_SCORE: 0.8181

RIG_SCORE: 0.5673

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P33A	TCGA-17-Z045	LUAD	TCGA	DSGPPT	DEG_SCF_TRCP1_1	0.6392
p.P33L	TCGA-AP-A0LG	UCEC	TCGA	DSGPPT	DEG_SCF_TRCP1_1	0.6471
p.P33L	DO41823	UCEC	ICGC	DSGPPT	DEG_SCF_TRCP1_1	0.6471
p.S30L	TCGA-CA-6717	COAD	TCGA	DSGPPT	DEG_SCF_TRCP1_1	0.8778
p.S30L	DO8264	COAD	ICGC	DSGPPT	DEG_SCF_TRCP1_1	0.8778
p.S30L	DO222762	COCA	ICGC	DSGPPT	DEG_SCF_TRCP1_1	0.8778
p.G31S	TCGA-FI-A2F4	UCEC	TCGA	DSGPPT	DEG_SCF_TRCP1_1	0.6993
p.G31S	DO43434	UCEC	ICGC	DSGPPT	DEG_SCF_TRCP1_1	0.6993
p.R42Q	DO222524	ESCA	ICGC	DSGPPT	DEG_SCF_TRCP1_1	0.1111
p.R42Q	SIDM01619	Endometrial Carcinoma	GDSC	DSGPPT	DEG_SCF_TRCP1_1	0.1111
p.R42Q	ACH-000984	Endometrial/Uterine Cancer	CCLE	DSGPPT	DEG_SCF_TRCP1_1	0.1111
p.P32T	DO229032	LICA	ICGC	DSGPPT	DEG_SCF_TRCP1_1	0.5919

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H1E3	Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1	DEG_SCF_TRCP1_1	29:34	DSGPPT	BTRC	0.9912	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons