DegronMD

Uniprot ID: Q9UDV7

Source protein: Zinc finger protein 282

Source gene: ZNF282

Class: DEG_SCF_TRCP1_1

Location: 390:396

E3 ligase: BTRC

DEGRON score: 0.9988

ASA_SCORE: 67.7571

COIL: 0.817

CONS_SCORE: 0.4771

DSS_SCORE: 0.7506

HELIX: 0.1453

FCONS_SCORE: 1.0819

RIG_SCORE: 0.5622

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G385R	TCGA-06-5416	GBM	TCGA	DSGPSDS	DEG_SCF_TRCP1_1	0.1944
p.G385R	TCGA-DU-5854	LGG	TCGA	DSGPSDS	DEG_SCF_TRCP1_1	0.1944
p.G385R	DO10880	GBM	ICGC	DSGPSDS	DEG_SCF_TRCP1_1	0.1944
p.G385R	DO22466	LGG	ICGC	DSGPSDS	DEG_SCF_TRCP1_1	0.1944
p.R380H	TCGA-86-A4JF	LUAD	TCGA	DSGPSDS	DEG_SCF_TRCP1_1	0.0556
p.R380H	TCGA-CG-5726	STAD	TCGA	DSGPSDS	DEG_SCF_TRCP1_1	0.0556
p.R380H	DO45317	LUAD	ICGC	DSGPSDS	DEG_SCF_TRCP1_1	0.0556
p.R380H	DO38483	STAD	ICGC	DSGPSDS	DEG_SCF_TRCP1_1	0.0556
p.R380H	SIDM01086	B-Lymphoblastic Leukemia	GDSC	DSGPSDS	DEG_SCF_TRCP1_1	0.0556
p.R380H	SIDM01617	Endometrial Carcinoma	GDSC	DSGPSDS	DEG_SCF_TRCP1_1	0.0556
p.R380H	ACH-000874	Leukemia	CCLE	DSGPSDS	DEG_SCF_TRCP1_1	0.0556
p.R380H	ACH-000994	Endometrial/Uterine Cancer	CCLE	DSGPSDS	DEG_SCF_TRCP1_1	0.0556
p.R380H	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	DSGPSDS	DEG_SCF_TRCP1_1	0.0556
p.D381N	TCGA-AX-A2HC	UCEC	TCGA	DSGPSDS	DEG_SCF_TRCP1_1	0.0833
p.D381N	DO41572	UCEC	ICGC	DSGPSDS	DEG_SCF_TRCP1_1	0.0833
p.D381N	SIDM01588	Endometrial Carcinoma	GDSC	DSGPSDS	DEG_SCF_TRCP1_1	0.0833
p.D381N	ACH-000993	Endometrial/Uterine Cancer	CCLE	DSGPSDS	DEG_SCF_TRCP1_1	0.0833
p.L387F	DO222540	COCA	ICGC	DSGPSDS	DEG_SCF_TRCP1_1	0.25
p.M383I	DO229038	LICA	ICGC	DSGPSDS	DEG_SCF_TRCP1_1	0.1389
p.A406T	DO50970	LICA	ICGC	DSGPSDS	DEG_SCF_TRCP1_1	0.0556
p.V400A	DO51524	PACA	ICGC	DSGPSDS	DEG_SCF_TRCP1_1	0.2222
p.A406P	DO229199	THCA	ICGC	DSGPSDS	DEG_SCF_TRCP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UDV7	Zinc finger protein 282	DEG_SCF_TRCP1_1	390:396	DSGPSDS	BTRC	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons