DegronMD - Q9UDV7(ZNF282)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G385R	TCGA-06-5416	GBM	TCGA	DSGPSDS	DEG_SCF_TRCP1_1	390:396	Mutation rewiring degron network	0.1944
p.G385R	TCGA-DU-5854	LGG	TCGA	DSGPSDS	DEG_SCF_TRCP1_1	390:396	Mutation rewiring degron network	0.1944
p.G385R	DO10880	GBM	ICGC	DSGPSDS	DEG_SCF_TRCP1_1	390:396	Mutation rewiring degron network	0.1944
p.G385R	DO22466	LGG	ICGC	DSGPSDS	DEG_SCF_TRCP1_1	390:396	Mutation rewiring degron network	0.1944
p.M61I	TCGA-23-1114	OV	TCGA	FPPFPD	LIG_APCC_ABBA_1	71:76	Mutation rewiring degron network	0.0556
p.M61I	DO32337	OV	ICGC	FPPFPD	LIG_APCC_ABBA_1	71:76	Mutation rewiring degron network	0.0556
p.R380H	TCGA-86-A4JF	LUAD	TCGA	DSGPSDS	DEG_SCF_TRCP1_1	390:396	Mutation rewiring degron network	0.0556
p.R380H	TCGA-CG-5726	STAD	TCGA	DSGPSDS	DEG_SCF_TRCP1_1	390:396	Mutation rewiring degron network	0.0556
p.R380H	DO45317	LUAD	ICGC	DSGPSDS	DEG_SCF_TRCP1_1	390:396	Mutation rewiring degron network	0.0556
p.R380H	DO38483	STAD	ICGC	DSGPSDS	DEG_SCF_TRCP1_1	390:396	Mutation rewiring degron network	0.0556
p.R380H	SIDM01086	B-Lymphoblastic Leukemia	GDSC	DSGPSDS	DEG_SCF_TRCP1_1	390:396	Mutation rewiring degron network	0.0556
p.R380H	SIDM01617	Endometrial Carcinoma	GDSC	DSGPSDS	DEG_SCF_TRCP1_1	390:396	Mutation rewiring degron network	0.0556
p.R380H	ACH-000874	Leukemia	CCLE	DSGPSDS	DEG_SCF_TRCP1_1	390:396	Mutation rewiring degron network	0.0556
p.R380H	ACH-000994	Endometrial/Uterine Cancer	CCLE	DSGPSDS	DEG_SCF_TRCP1_1	390:396	Mutation rewiring degron network	0.0556
p.R380H	RS4-11	haematopoietic and lymphoid tissue	COSMIC	DSGPSDS	DEG_SCF_TRCP1_1	390:396	Mutation rewiring degron network	0.0556
p.P68S	TCGA-A5-A0G2	UCEC	TCGA	FPPFPD	LIG_APCC_ABBA_1	71:76	Mutation rewiring degron network	0.25
p.P68S	TCGA-A5-A0G2	UCEC	TCGA	RAPVFPD	LIG_APCC_ABBAyCdc20_2	77:83	Mutation rewiring degron network	0.0833
p.P68S	DO41235	UCEC	ICGC	FPPFPD	LIG_APCC_ABBA_1	71:76	Mutation rewiring degron network	0.25
p.P68S	DO41235	UCEC	ICGC	RAPVFPD	LIG_APCC_ABBAyCdc20_2	77:83	Mutation rewiring degron network	0.0833
p.D381N	TCGA-AX-A2HC	UCEC	TCGA	DSGPSDS	DEG_SCF_TRCP1_1	390:396	Mutation rewiring degron network	0.0833
p.D381N	DO41572	UCEC	ICGC	DSGPSDS	DEG_SCF_TRCP1_1	390:396	Mutation rewiring degron network	0.0833
p.D381N	SIDM01588	Endometrial Carcinoma	GDSC	DSGPSDS	DEG_SCF_TRCP1_1	390:396	Mutation rewiring degron network	0.0833
p.D381N	ACH-000993	Endometrial/Uterine Cancer	CCLE	DSGPSDS	DEG_SCF_TRCP1_1	390:396	Mutation rewiring degron network	0.0833
p.R87Q	TCGA-CN-4723	HNSC	TCGA	RAPVFPD	LIG_APCC_ABBAyCdc20_2	77:83	Mutation rewiring degron network	0.2222
p.R87Q	DO14830	HNSC	ICGC	RAPVFPD	LIG_APCC_ABBAyCdc20_2	77:83	Mutation rewiring degron network	0.2222
p.Q90L	TCGA-DD-AACE	LIHC	TCGA	RAPVFPD	LIG_APCC_ABBAyCdc20_2	77:83	Mutation rewiring degron network	0.1389
p.Q90L	DO52200	LIHC	ICGC	RAPVFPD	LIG_APCC_ABBAyCdc20_2	77:83	Mutation rewiring degron network	0.1389
p.M67L	TCGA-DD-AAEI	LIHC	TCGA	FPPFPD	LIG_APCC_ABBA_1	71:76	Mutation rewiring degron network	0.2222
p.M67L	TCGA-DD-AAEI	LIHC	TCGA	RAPVFPD	LIG_APCC_ABBAyCdc20_2	77:83	Mutation rewiring degron network	0.0556
p.M67L	DO219575	LIHC	ICGC	FPPFPD	LIG_APCC_ABBA_1	71:76	Mutation rewiring degron network	0.2222
p.M67L	DO219575	LIHC	ICGC	RAPVFPD	LIG_APCC_ABBAyCdc20_2	77:83	Mutation rewiring degron network	0.0556
p.M85T	TCGA-EY-A1GF	UCEC	TCGA	FPPFPD	LIG_APCC_ABBA_1	71:76	Mutation rewiring degron network	0.0833
p.M85T	TCGA-EY-A1GF	UCEC	TCGA	RAPVFPD	LIG_APCC_ABBAyCdc20_2	77:83	Mutation rewiring degron network	0.2778
p.M85T	DO41704	UCEC	ICGC	FPPFPD	LIG_APCC_ABBA_1	71:76	Mutation rewiring degron network	0.0833
p.M85T	DO41704	UCEC	ICGC	RAPVFPD	LIG_APCC_ABBAyCdc20_2	77:83	Mutation rewiring degron network	0.2778
p.F71L	TCGA-FI-A2D5	UCEC	TCGA	FPPFPD	LIG_APCC_ABBA_1	71:76	Mutation altering degron motif	0.587
p.F71L	DO41331	UCEC	ICGC	FPPFPD	LIG_APCC_ABBA_1	71:76	Mutation altering degron motif	0.587
p.L387F	DO222540	COCA	ICGC	DSGPSDS	DEG_SCF_TRCP1_1	390:396	Mutation rewiring degron network	0.25
p.R64Q	DO50442	ESAD	ICGC	FPPFPD	LIG_APCC_ABBA_1	71:76	Mutation rewiring degron network	0.1389
p.A63T	DO233064	GACA	ICGC	FPPFPD	LIG_APCC_ABBA_1	71:76	Mutation rewiring degron network	0.1111
p.L91F	DO229026	LICA	ICGC	RAPVFPD	LIG_APCC_ABBAyCdc20_2	77:83	Mutation rewiring degron network	0.1111
p.M383I	DO229038	LICA	ICGC	DSGPSDS	DEG_SCF_TRCP1_1	390:396	Mutation rewiring degron network	0.1389
p.A406T	DO50970	LICA	ICGC	DSGPSDS	DEG_SCF_TRCP1_1	390:396	Mutation rewiring degron network	0.0556
p.V400A	DO51524	PACA	ICGC	DSGPSDS	DEG_SCF_TRCP1_1	390:396	Mutation rewiring degron network	0.2222
p.R65W	DO48899	PBCA	ICGC	FPPFPD	LIG_APCC_ABBA_1	71:76	Mutation rewiring degron network	0.1667
p.A406P	DO229199	THCA	ICGC	DSGPSDS	DEG_SCF_TRCP1_1	390:396	Mutation rewiring degron network	0.0556

Kaplan plot for ZNF282 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF282

UniProt ID: Q9UDV7

Entrez ID: 8427

Protein name: Zinc finger protein 282 (HTLV-I U5RE-binding protein 1) (HUB-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF282 in