DegronMD

Uniprot ID: Q9UDV7

Source protein: Zinc finger protein 282

Source gene: ZNF282

Class: LIG_APCC_ABBA_1

Location: 71:76

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.969

ASA_SCORE: 79.9333

COIL: 0.9502

CONS_SCORE: 0.7035

DSS_SCORE: 0.5094

HELIX: 0.0253

FCONS_SCORE: 0.9639

RIG_SCORE: 0.6757

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M61I	TCGA-23-1114	OV	TCGA	FPPFPD	LIG_APCC_ABBA_1	0.0556
p.M61I	DO32337	OV	ICGC	FPPFPD	LIG_APCC_ABBA_1	0.0556
p.P68S	TCGA-A5-A0G2	UCEC	TCGA	FPPFPD	LIG_APCC_ABBA_1	0.25
p.P68S	DO41235	UCEC	ICGC	FPPFPD	LIG_APCC_ABBA_1	0.25
p.M67L	TCGA-DD-AAEI	LIHC	TCGA	FPPFPD	LIG_APCC_ABBA_1	0.2222
p.M67L	DO219575	LIHC	ICGC	FPPFPD	LIG_APCC_ABBA_1	0.2222
p.M85T	TCGA-EY-A1GF	UCEC	TCGA	FPPFPD	LIG_APCC_ABBA_1	0.0833
p.M85T	DO41704	UCEC	ICGC	FPPFPD	LIG_APCC_ABBA_1	0.0833
p.F71L	TCGA-FI-A2D5	UCEC	TCGA	FPPFPD	LIG_APCC_ABBA_1	0.587
p.F71L	DO41331	UCEC	ICGC	FPPFPD	LIG_APCC_ABBA_1	0.587
p.R64Q	DO50442	ESAD	ICGC	FPPFPD	LIG_APCC_ABBA_1	0.1389
p.A63T	DO233064	GACA	ICGC	FPPFPD	LIG_APCC_ABBA_1	0.1111
p.R65W	DO48899	PBCA	ICGC	FPPFPD	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UDV7	Zinc finger protein 282	LIG_APCC_ABBA_1	71:76	FPPFPD	APC,CDC20,FZR1	0.969	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons