DegronMD

Uniprot ID: Q9UDV7

Source protein: Zinc finger protein 282

Source gene: ZNF282

Class: LIG_APCC_ABBAyCdc20_2

Location: 77:83

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5994

ASA_SCORE: 85.2714

COIL: 0.8603

CONS_SCORE: 0.7205

DSS_SCORE: 0.503

HELIX: 0.0837

FCONS_SCORE: 0.9544

RIG_SCORE: 0.7464

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P68S	TCGA-A5-A0G2	UCEC	TCGA	RAPVFPD	LIG_APCC_ABBAyCdc20_2	0.0833
p.P68S	DO41235	UCEC	ICGC	RAPVFPD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R87Q	TCGA-CN-4723	HNSC	TCGA	RAPVFPD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R87Q	DO14830	HNSC	ICGC	RAPVFPD	LIG_APCC_ABBAyCdc20_2	0.2222
p.Q90L	TCGA-DD-AACE	LIHC	TCGA	RAPVFPD	LIG_APCC_ABBAyCdc20_2	0.1389
p.Q90L	DO52200	LIHC	ICGC	RAPVFPD	LIG_APCC_ABBAyCdc20_2	0.1389
p.M67L	TCGA-DD-AAEI	LIHC	TCGA	RAPVFPD	LIG_APCC_ABBAyCdc20_2	0.0556
p.M67L	DO219575	LIHC	ICGC	RAPVFPD	LIG_APCC_ABBAyCdc20_2	0.0556
p.M85T	TCGA-EY-A1GF	UCEC	TCGA	RAPVFPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.M85T	DO41704	UCEC	ICGC	RAPVFPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.L91F	DO229026	LICA	ICGC	RAPVFPD	LIG_APCC_ABBAyCdc20_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UDV7	Zinc finger protein 282	LIG_APCC_ABBAyCdc20_2	77:83	RAPVFPD	APC,CDC20,FZR1	0.5994	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons