DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DSGQPT
Uniprot ID:
Q8NDA2
Source protein:
Hemicentin-2
Source gene:
HMCN2
Class:
DEG_SCF_TRCP1_1
Location:
3506:3511
E3 ligase:
BTRC
DEGRON score:
0.9949
ASA_SCORE:
72.9833
COIL:
0.8247
CONS_SCORE:
0.4378
DSS_SCORE:
0.7055
HELIX:
0.0223
FCONS_SCORE:
1.4768
RIG_SCORE:
0.6228
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E3505D
SIDM02041
Colorectal Carcinoma
GDSC
DSGQPT
DEG_SCF_TRCP1_1
0.3056
p.V3498I
SIDM00092
Ovarian Carcinoma
GDSC
DSGQPT
DEG_SCF_TRCP1_1
0.1111
Drug responses associated with HMCN2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSGQPT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NDA2
Hemicentin-2
DEG_SCF_TRCP1_1
3506:3511
DSGQPT
BTRC
0.9949
More...