DegronMD - Q8NDA2(HMCN2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G628R	TCGA-A5-A1OF	UCEC	TCGA	PTPHIS	DEG_SCF_FBW7_1	634:639	Mutation rewiring degron network	0.1667
p.G628R	DO42568	UCEC	ICGC	PTPHIS	DEG_SCF_FBW7_1	634:639	Mutation rewiring degron network	0.1667
p.E636K	TCGA-B5-A3FA	UCEC	TCGA	PTPHIS	DEG_SCF_FBW7_1	634:639	Mutation altering degron motif	0.7022
p.E636K	DO52402	UCEC	ICGC	PTPHIS	DEG_SCF_FBW7_1	634:639	Mutation altering degron motif	0.7022
p.E627G	DO228641	GACA	ICGC	PTPHIS	DEG_SCF_FBW7_1	634:639	Mutation rewiring degron network	0.1389
p.G647V	DO228952	LICA	ICGC	PTPHIS	DEG_SCF_FBW7_1	634:639	Mutation rewiring degron network	0.1111
p.G647V	DO229022	LICA	ICGC	PTPHIS	DEG_SCF_FBW7_1	634:639	Mutation rewiring degron network	0.1111
p.Q632H	DO229041	LICA	ICGC	PTPHIS	DEG_SCF_FBW7_1	634:639	Mutation rewiring degron network	0.2778
p.G628W	DO229008	LICA	ICGC	PTPHIS	DEG_SCF_FBW7_1	634:639	Mutation rewiring degron network	0.1667
p.M649K	DO24130	LUAD	ICGC	PTPHIS	DEG_SCF_FBW7_1	634:639	Mutation rewiring degron network	0.0556
p.P638S	DO229272	THCA	ICGC	PTPHIS	DEG_SCF_FBW7_1	634:639	Mutation altering degron motif	0.6752
p.E626G	DO229216	THCA	ICGC	PTPHIS	DEG_SCF_FBW7_1	634:639	Mutation rewiring degron network	0.1111
p.E3505D	SIDM02041	Colorectal Carcinoma	GDSC	DSGQPT	DEG_SCF_TRCP1_1	3506:3511	Mutation rewiring degron network	0.3056
p.R3192H	SIDM02021	Esophageal Carcinoma	GDSC	GRLQLSRLQ	DEG_APCC_DBOX_1	3186:3194	Mutation altering degron motif	0.7133
p.E643Q	SIDM00684	Glioblastoma	GDSC	PTPHIS	DEG_SCF_FBW7_1	634:639	Mutation rewiring degron network	0.2222
p.E643Q	LN-229	central nervous system	COSMIC	PTPHIS	DEG_SCF_FBW7_1	634:639	Mutation rewiring degron network	0.2222
p.C628S	SIDM00856	Other Solid Cancers	GDSC	PTPHIS	DEG_SCF_FBW7_1	634:639	Mutation rewiring degron network	0.1667
p.C628S	SIDM00505	Pancreatic Carcinoma	GDSC	PTPHIS	DEG_SCF_FBW7_1	634:639	Mutation rewiring degron network	0.1667
p.R3184Q	SIDM00311	Mesothelioma	GDSC	GRLQLSRLQ	DEG_APCC_DBOX_1	3186:3194	Mutation rewiring degron network	0.2778
p.R3184Q	H2810	pleura	COSMIC	GRLQLSRLQ	DEG_APCC_DBOX_1	3186:3194	Mutation rewiring degron network	0.2778
p.V3498I	SIDM00092	Ovarian Carcinoma	GDSC	DSGQPT	DEG_SCF_TRCP1_1	3506:3511	Mutation rewiring degron network	0.1111
p.R642C	SIDM00579	Neuroblastoma	GDSC	PTPHIS	DEG_SCF_FBW7_1	634:639	Mutation rewiring degron network	0.25
p.R642C	NB(TU)1-10	autonomic ganglia	COSMIC	PTPHIS	DEG_SCF_FBW7_1	634:639	Mutation rewiring degron network	0.25
p.R642H	NCI-H211	lung	COSMIC	PTPHIS	DEG_SCF_FBW7_1	634:639	Mutation rewiring degron network	0.25
p.R642H	SK-N-FI	autonomic ganglia	COSMIC	PTPHIS	DEG_SCF_FBW7_1	634:639	Mutation rewiring degron network	0.25

Kaplan plot for HMCN2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HMCN2

UniProt ID: Q8NDA2

Entrez ID:

Protein name: Hemicentin-2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HMCN2 in