DegronMD

Uniprot ID: Q8NDA2

Source protein: Hemicentin-2

Source gene: HMCN2

Class: DEG_SCF_FBW7_1

Location: 634:639

E3 ligase: FBXW7

DEGRON score: 0.5969

ASA_SCORE: 56.3

COIL: 0.4917

CONS_SCORE: 0.507

DSS_SCORE: 0.4414

HELIX: 0.0058

FCONS_SCORE: 1.0987

RIG_SCORE: 0.7232

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E636K	TCGA-B5-A3FA	UCEC	TCGA	PTPHIS	DEG_SCF_FBW7_1	0.7022
p.E636K	DO52402	UCEC	ICGC	PTPHIS	DEG_SCF_FBW7_1	0.7022
p.P638S	DO229272	THCA	ICGC	PTPHIS	DEG_SCF_FBW7_1	0.6752
p.Q632H	DO229041	LICA	ICGC	PTPHIS	DEG_SCF_FBW7_1	0.2778
p.R642C	SIDM00579	Neuroblastoma	GDSC	PTPHIS	DEG_SCF_FBW7_1	0.25
p.R642C	NB(TU)1-10	autonomic_ganglia	COSMIC	PTPHIS	DEG_SCF_FBW7_1	0.25
p.R642H	NCI-H211	lung	COSMIC	PTPHIS	DEG_SCF_FBW7_1	0.25
p.R642H	SK-N-FI	autonomic_ganglia	COSMIC	PTPHIS	DEG_SCF_FBW7_1	0.25
p.E643Q	SIDM00684	Glioblastoma	GDSC	PTPHIS	DEG_SCF_FBW7_1	0.2222
p.E643Q	LN-229	central_nervous_system	COSMIC	PTPHIS	DEG_SCF_FBW7_1	0.2222
p.G628R	TCGA-A5-A1OF	UCEC	TCGA	PTPHIS	DEG_SCF_FBW7_1	0.1667
p.G628R	DO42568	UCEC	ICGC	PTPHIS	DEG_SCF_FBW7_1	0.1667
p.G628W	DO229008	LICA	ICGC	PTPHIS	DEG_SCF_FBW7_1	0.1667
p.C628S	SIDM00856	Other Solid Cancers	GDSC	PTPHIS	DEG_SCF_FBW7_1	0.1667
p.C628S	SIDM00505	Pancreatic Carcinoma	GDSC	PTPHIS	DEG_SCF_FBW7_1	0.1667
p.E627G	DO228641	GACA	ICGC	PTPHIS	DEG_SCF_FBW7_1	0.1389
p.G647V	DO228952	LICA	ICGC	PTPHIS	DEG_SCF_FBW7_1	0.1111
p.G647V	DO229022	LICA	ICGC	PTPHIS	DEG_SCF_FBW7_1	0.1111
p.E626G	DO229216	THCA	ICGC	PTPHIS	DEG_SCF_FBW7_1	0.1111
p.M649K	DO24130	LUAD	ICGC	PTPHIS	DEG_SCF_FBW7_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NDA2	Hemicentin-2	DEG_SCF_FBW7_1	634:639	PTPHIS	FBXW7	0.5969	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons