DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
GRLQLSRLQ
Uniprot ID:
Q8NDA2
Source protein:
Hemicentin-2
Source gene:
HMCN2
Class:
DEG_APCC_DBOX_1
Location:
3186:3194
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9605
ASA_SCORE:
52.6889
COIL:
0.5008
CONS_SCORE:
0.6655
DSS_SCORE:
0.3574
HELIX:
0.0048
FCONS_SCORE:
1.3675
RIG_SCORE:
0.7453
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R3192H
SIDM02021
Esophageal Carcinoma
GDSC
GRLQLSRLQ
DEG_APCC_DBOX_1
0.7133
p.R3184Q
SIDM00311
Mesothelioma
GDSC
GRLQLSRLQ
DEG_APCC_DBOX_1
0.2778
p.R3184Q
H2810
pleura
COSMIC
GRLQLSRLQ
DEG_APCC_DBOX_1
0.2778
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Drug responses associated with HMCN2 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of GRLQLSRLQ
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NDA2
Hemicentin-2
DEG_APCC_DBOX_1
3186:3194
GRLQLSRLQ
APC,CDC20,FZR1
0.9605
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