DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
GRLQLSRLQ
Uniprot ID:
Q8NDA2
Source protein:
Hemicentin-2
Source gene:
HMCN2
Class:
DEG_APCC_DBOX_1
Location:
3186:3194
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9605
ASA_SCORE:
52.6889
COIL:
0.5008
CONS_SCORE:
0.6655
DSS_SCORE:
0.3574
HELIX:
0.0048
FCONS_SCORE:
1.3675
RIG_SCORE:
0.7453
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R3192H
SIDM02021
Esophageal Carcinoma
GDSC
GRLQLSRLQ
DEG_APCC_DBOX_1
0.7133
p.R3184Q
SIDM00311
Mesothelioma
GDSC
GRLQLSRLQ
DEG_APCC_DBOX_1
0.2778
p.R3184Q
H2810
pleura
COSMIC
GRLQLSRLQ
DEG_APCC_DBOX_1
0.2778
Drug responses associated with HMCN2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of GRLQLSRLQ
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NDA2
Hemicentin-2
DEG_APCC_DBOX_1
3186:3194
GRLQLSRLQ
APC,CDC20,FZR1
0.9605
More...