DegronMD

Uniprot ID: P22223

Source protein: Cadherin-3

Source gene: CDH3

Class: DEG_SCF_TRCP1_1

Location: 491:496

E3 ligase: BTRC

DEGRON score: 0.6746

ASA_SCORE: 50.3167

COIL: 0.4727

CONS_SCORE: 0.543

DSS_SCORE: 0.4249

HELIX: 0.0117

FCONS_SCORE: 1.0992

RIG_SCORE: 0.7178

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D502N	TCGA-95-7944	LUAD	TCGA	DSGQVT	DEG_SCF_TRCP1_1	0.1667
p.D502N	DO25163	LUAD	ICGC	DSGQVT	DEG_SCF_TRCP1_1	0.1667
p.D502G	TCGA-CG-5721	STAD	TCGA	DSGQVT	DEG_SCF_TRCP1_1	0.1667
p.D502G	DO38192	STAD	ICGC	DSGQVT	DEG_SCF_TRCP1_1	0.1667
p.R503C	TCGA-K4-A5RI	BLCA	TCGA	DSGQVT	DEG_SCF_TRCP1_1	0.1389
p.R503C	DO219029	BLCA	ICGC	DSGQVT	DEG_SCF_TRCP1_1	0.1389
p.R503C	DO234207	ESAD	ICGC	DSGQVT	DEG_SCF_TRCP1_1	0.1389
p.S492G	DO233154	GACA	ICGC	DSGQVT	DEG_SCF_TRCP1_1	0.8104
p.G499V	DO228952	LICA	ICGC	DSGQVT	DEG_SCF_TRCP1_1	0.25
p.Q494K	SIDM00653	Small Cell Lung Carcinoma	GDSC	DSGQVT	DEG_SCF_TRCP1_1	0.5833
p.Q494K	ACH-000514	Lung Cancer	CCLE	DSGQVT	DEG_SCF_TRCP1_1	0.5833
p.Q494K	NCI-H1092	lung	COSMIC	DSGQVT	DEG_SCF_TRCP1_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P22223	Cadherin-3	DEG_SCF_TRCP1_1	491:496	DSGQVT	BTRC	0.6746	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons