DegronMD - P22223(CDH3)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D502N	TCGA-95-7944	LUAD	TCGA	DSGQVT	DEG_SCF_TRCP1_1	491:496	Mutation rewiring degron network	0.1667
p.D502N	DO25163	LUAD	ICGC	DSGQVT	DEG_SCF_TRCP1_1	491:496	Mutation rewiring degron network	0.1667
p.V541I	TCGA-AA-A00N	COAD	TCGA	DVNDHGPVPEP	DEG_COP1_1	540:550	Mutation altering degron motif	0.5965
p.V541I	DO9876	COAD	ICGC	DVNDHGPVPEP	DEG_COP1_1	540:550	Mutation altering degron motif	0.5965
p.D543N	TCGA-B5-A11E	UCEC	TCGA	DVNDHGPVPEP	DEG_COP1_1	540:550	Mutation altering degron motif	0.6932
p.D543N	DO41644	UCEC	ICGC	DVNDHGPVPEP	DEG_COP1_1	540:550	Mutation altering degron motif	0.6932
p.E289G	TCGA-B5-A1MX	UCEC	TCGA	SSGLDREKVPEY	DEG_COP1_1	283:294	Mutation altering degron motif	0.6087
p.E289G	DO41999	UCEC	ICGC	SSGLDREKVPEY	DEG_COP1_1	283:294	Mutation altering degron motif	0.6087
p.R274W	TCGA-BR-A4QL	STAD	TCGA	SSGLDREKVPEY	DEG_COP1_1	283:294	Mutation rewiring degron network	0.0833
p.R274W	DO38723	STAD	ICGC	SSGLDREKVPEY	DEG_COP1_1	283:294	Mutation rewiring degron network	0.0833
p.R274W	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	SSGLDREKVPEY	DEG_COP1_1	283:294	Mutation rewiring degron network	0.0833
p.R274W	SIDM00483	Esophageal Carcinoma	GDSC	SSGLDREKVPEY	DEG_COP1_1	283:294	Mutation rewiring degron network	0.0833
p.R274W	ACH-001654	Esophageal Cancer	CCLE	SSGLDREKVPEY	DEG_COP1_1	283:294	Mutation rewiring degron network	0.0833
p.R274W	ACH-002220	Lymphoma	CCLE	SSGLDREKVPEY	DEG_COP1_1	283:294	Mutation rewiring degron network	0.0833
p.R274W	SK-GT-4	oesophagus	COSMIC	SSGLDREKVPEY	DEG_COP1_1	283:294	Mutation rewiring degron network	0.0833
p.R274W	CRO-AP2	haematopoietic and lymphoid tissue	COSMIC	SSGLDREKVPEY	DEG_COP1_1	283:294	Mutation rewiring degron network	0.0833
p.D502G	TCGA-CG-5721	STAD	TCGA	DSGQVT	DEG_SCF_TRCP1_1	491:496	Mutation rewiring degron network	0.1667
p.D502G	DO38192	STAD	ICGC	DSGQVT	DEG_SCF_TRCP1_1	491:496	Mutation rewiring degron network	0.1667
p.Q552K	TCGA-DD-A4NJ	LIHC	TCGA	DVNDHGPVPEP	DEG_COP1_1	540:550	Mutation rewiring degron network	0.2778
p.Q552K	DO44873	LIHC	ICGC	DVNDHGPVPEP	DEG_COP1_1	540:550	Mutation rewiring degron network	0.2778
p.T531M	TCGA-EO-A22R	UCEC	TCGA	DVNDHGPVPEP	DEG_COP1_1	540:550	Mutation rewiring degron network	0.0833
p.T531M	DO42713	UCEC	ICGC	DVNDHGPVPEP	DEG_COP1_1	540:550	Mutation rewiring degron network	0.0833
p.R503C	TCGA-K4-A5RI	BLCA	TCGA	DSGQVT	DEG_SCF_TRCP1_1	491:496	Mutation rewiring degron network	0.1389
p.R503C	DO219029	BLCA	ICGC	DSGQVT	DEG_SCF_TRCP1_1	491:496	Mutation rewiring degron network	0.1389
p.R503C	DO234207	ESAD	ICGC	DSGQVT	DEG_SCF_TRCP1_1	491:496	Mutation rewiring degron network	0.1389
p.R288W	TCGA-NK-A5D1	LUSC	TCGA	SSGLDREKVPEY	DEG_COP1_1	283:294	Mutation altering degron motif	0.7523
p.R288W	DO219213	LUSC	ICGC	SSGLDREKVPEY	DEG_COP1_1	283:294	Mutation altering degron motif	0.7523
p.R288W	SIDM00837	Colorectal Carcinoma	GDSC	SSGLDREKVPEY	DEG_COP1_1	283:294	Mutation altering degron motif	0.7523
p.R288W	ACH-000958	Colon/Colorectal Cancer	CCLE	SSGLDREKVPEY	DEG_COP1_1	283:294	Mutation altering degron motif	0.7523
p.S492G	DO233154	GACA	ICGC	DSGQVT	DEG_SCF_TRCP1_1	491:496	Mutation altering degron motif	0.8104
p.G499V	DO228952	LICA	ICGC	DSGQVT	DEG_SCF_TRCP1_1	491:496	Mutation rewiring degron network	0.25
p.V547F	DO228986	LICA	ICGC	DVNDHGPVPEP	DEG_COP1_1	540:550	Mutation altering degron motif	0.7068
p.I553T	DO51513	PACA	ICGC	DVNDHGPVPEP	DEG_COP1_1	540:550	Mutation rewiring degron network	0.25
p.M303I	SIDM00917	Acute Myeloid Leukemia	GDSC	SSGLDREKVPEY	DEG_COP1_1	283:294	Mutation rewiring degron network	0.0833
p.M303I	SIDM00261	Ewing's Sarcoma	GDSC	SSGLDREKVPEY	DEG_COP1_1	283:294	Mutation rewiring degron network	0.0833
p.L296M	SIDM00796	Head and Neck Carcinoma	GDSC	SSGLDREKVPEY	DEG_COP1_1	283:294	Mutation rewiring degron network	0.2778
p.L296M	ACH-000740	Head and Neck Cancer	CCLE	SSGLDREKVPEY	DEG_COP1_1	283:294	Mutation rewiring degron network	0.2778
p.L296M	A253	salivary gland	COSMIC	SSGLDREKVPEY	DEG_COP1_1	283:294	Mutation rewiring degron network	0.2778
p.Q494K	SIDM00653	Small Cell Lung Carcinoma	GDSC	DSGQVT	DEG_SCF_TRCP1_1	491:496	Mutation altering degron motif	0.5833
p.Q494K	ACH-000514	Lung Cancer	CCLE	DSGQVT	DEG_SCF_TRCP1_1	491:496	Mutation altering degron motif	0.5833
p.Q494K	NCI-H1092	lung	COSMIC	DSGQVT	DEG_SCF_TRCP1_1	491:496	Mutation altering degron motif	0.5833
p.P550S	SIDM00179	Melanoma	GDSC	DVNDHGPVPEP	DEG_COP1_1	540:550	Mutation altering degron motif	0.6752
p.P550S	ACH-002165	Skin Cancer	CCLE	DVNDHGPVPEP	DEG_COP1_1	540:550	Mutation altering degron motif	0.6752
p.P550S	MZ2-MEL	skin	COSMIC	DVNDHGPVPEP	DEG_COP1_1	540:550	Mutation altering degron motif	0.6752
p.V541A	SIDM00217	Colorectal Carcinoma	GDSC	DVNDHGPVPEP	DEG_COP1_1	540:550	Mutation altering degron motif	0.5825
p.V541A	ACH-000999	Colon/Colorectal Cancer	CCLE	DVNDHGPVPEP	DEG_COP1_1	540:550	Mutation altering degron motif	0.5825
p.V541A	SNU-1040	large intestine	COSMIC	DVNDHGPVPEP	DEG_COP1_1	540:550	Mutation altering degron motif	0.5825
p.T297S	ACH-001628	Ovarian Cancer	CCLE	SSGLDREKVPEY	DEG_COP1_1	283:294	Mutation rewiring degron network	0.25

Kaplan plot for CDH3 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDH3

UniProt ID: P22223

Entrez ID: 1001

Protein name: Cadherin-3 (Placental cadherin) (P-cadherin)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CDH3 in