DegronMD

Uniprot ID: P22223

Source protein: Cadherin-3

Source gene: CDH3

Class: DEG_COP1_1

Location: 283:294

E3 ligase: COP1

DEGRON score: 0.628

ASA_SCORE: 64.625

COIL: 0.6597

CONS_SCORE: 0.5349

DSS_SCORE: 0.3971

HELIX: 0.0833

FCONS_SCORE: 1.0468

RIG_SCORE: 0.7755

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E289G	TCGA-B5-A1MX	UCEC	TCGA	SSGLDREKVPEY	DEG_COP1_1	0.6087
p.E289G	DO41999	UCEC	ICGC	SSGLDREKVPEY	DEG_COP1_1	0.6087
p.R274W	TCGA-BR-A4QL	STAD	TCGA	SSGLDREKVPEY	DEG_COP1_1	0.0833
p.R274W	DO38723	STAD	ICGC	SSGLDREKVPEY	DEG_COP1_1	0.0833
p.R274W	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	SSGLDREKVPEY	DEG_COP1_1	0.0833
p.R274W	SIDM00483	Esophageal Carcinoma	GDSC	SSGLDREKVPEY	DEG_COP1_1	0.0833
p.R274W	ACH-001654	Esophageal Cancer	CCLE	SSGLDREKVPEY	DEG_COP1_1	0.0833
p.R274W	ACH-002220	Lymphoma	CCLE	SSGLDREKVPEY	DEG_COP1_1	0.0833
p.R274W	SK-GT-4	oesophagus	COSMIC	SSGLDREKVPEY	DEG_COP1_1	0.0833
p.R274W	CRO-AP2	haematopoietic_and_lymphoid_tissue	COSMIC	SSGLDREKVPEY	DEG_COP1_1	0.0833
p.R288W	TCGA-NK-A5D1	LUSC	TCGA	SSGLDREKVPEY	DEG_COP1_1	0.7523
p.R288W	DO219213	LUSC	ICGC	SSGLDREKVPEY	DEG_COP1_1	0.7523
p.R288W	SIDM00837	Colorectal Carcinoma	GDSC	SSGLDREKVPEY	DEG_COP1_1	0.7523
p.R288W	ACH-000958	Colon/Colorectal Cancer	CCLE	SSGLDREKVPEY	DEG_COP1_1	0.7523
p.M303I	SIDM00917	Acute Myeloid Leukemia	GDSC	SSGLDREKVPEY	DEG_COP1_1	0.0833
p.M303I	SIDM00261	Ewing's Sarcoma	GDSC	SSGLDREKVPEY	DEG_COP1_1	0.0833
p.L296M	SIDM00796	Head and Neck Carcinoma	GDSC	SSGLDREKVPEY	DEG_COP1_1	0.2778
p.L296M	ACH-000740	Head and Neck Cancer	CCLE	SSGLDREKVPEY	DEG_COP1_1	0.2778
p.L296M	A253	salivary_gland	COSMIC	SSGLDREKVPEY	DEG_COP1_1	0.2778
p.T297S	ACH-001628	Ovarian Cancer	CCLE	SSGLDREKVPEY	DEG_COP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P22223	Cadherin-3	DEG_COP1_1	283:294	SSGLDREKVPEY	COP1	0.628	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons