DegronMD

Uniprot ID: P22223

Source protein: Cadherin-3

Source gene: CDH3

Class: DEG_COP1_1

Location: 540:550

E3 ligase: COP1

DEGRON score: 0.9919

ASA_SCORE: 53.7091

COIL: 0.7385

CONS_SCORE: 0.5386

DSS_SCORE: 0.4286

HELIX: 0.0263

FCONS_SCORE: 1.115

RIG_SCORE: 0.738

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V541I	TCGA-AA-A00N	COAD	TCGA	DVNDHGPVPEP	DEG_COP1_1	0.5965
p.V541I	DO9876	COAD	ICGC	DVNDHGPVPEP	DEG_COP1_1	0.5965
p.D543N	TCGA-B5-A11E	UCEC	TCGA	DVNDHGPVPEP	DEG_COP1_1	0.6932
p.D543N	DO41644	UCEC	ICGC	DVNDHGPVPEP	DEG_COP1_1	0.6932
p.Q552K	TCGA-DD-A4NJ	LIHC	TCGA	DVNDHGPVPEP	DEG_COP1_1	0.2778
p.Q552K	DO44873	LIHC	ICGC	DVNDHGPVPEP	DEG_COP1_1	0.2778
p.T531M	TCGA-EO-A22R	UCEC	TCGA	DVNDHGPVPEP	DEG_COP1_1	0.0833
p.T531M	DO42713	UCEC	ICGC	DVNDHGPVPEP	DEG_COP1_1	0.0833
p.V547F	DO228986	LICA	ICGC	DVNDHGPVPEP	DEG_COP1_1	0.7068
p.I553T	DO51513	PACA	ICGC	DVNDHGPVPEP	DEG_COP1_1	0.25
p.P550S	SIDM00179	Melanoma	GDSC	DVNDHGPVPEP	DEG_COP1_1	0.6752
p.P550S	ACH-002165	Skin Cancer	CCLE	DVNDHGPVPEP	DEG_COP1_1	0.6752
p.P550S	MZ2-MEL	skin	COSMIC	DVNDHGPVPEP	DEG_COP1_1	0.6752
p.V541A	SIDM00217	Colorectal Carcinoma	GDSC	DVNDHGPVPEP	DEG_COP1_1	0.5825
p.V541A	ACH-000999	Colon/Colorectal Cancer	CCLE	DVNDHGPVPEP	DEG_COP1_1	0.5825
p.V541A	SNU-1040	large_intestine	COSMIC	DVNDHGPVPEP	DEG_COP1_1	0.5825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P22223	Cadherin-3	DEG_COP1_1	540:550	DVNDHGPVPEP	COP1	0.9919	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons