DegronMD

Uniprot ID: Q5JR98

Source protein: Dynein light chain Tctex-type 4

Source gene: DYNLT4

Class: DEG_SCF_TRCP1_1

Location: 18:24

E3 ligase: BTRC

DEGRON score: 0.8951

ASA_SCORE: 97.0857

COIL: 0.9383

CONS_SCORE: 0.3148

DSS_SCORE: 0.7798

HELIX: 0.0517

FCONS_SCORE: 1.0179

RIG_SCORE: 0.5417

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R27Q	TCGA-2W-A8YY	CESC	TCGA	DSGRKPS	DEG_SCF_TRCP1_1	0.25
p.R27Q	DO223732	CESC	ICGC	DSGRKPS	DEG_SCF_TRCP1_1	0.25
p.R21W	TCGA-32-2616	GBM	TCGA	DSGRKPS	DEG_SCF_TRCP1_1	0.7523
p.R21W	DO13462	GBM	ICGC	DSGRKPS	DEG_SCF_TRCP1_1	0.7523
p.G9V	TCGA-DU-6404	LGG	TCGA	DSGRKPS	DEG_SCF_TRCP1_1	0.0833
p.G9V	DO22207	LGG	ICGC	DSGRKPS	DEG_SCF_TRCP1_1	0.0833
p.R27G	TCGA-EO-A22U	UCEC	TCGA	DSGRKPS	DEG_SCF_TRCP1_1	0.25
p.R27G	DO43755	UCEC	ICGC	DSGRKPS	DEG_SCF_TRCP1_1	0.25
p.R10S	TCGA-Q1-A73P	CESC	TCGA	DSGRKPS	DEG_SCF_TRCP1_1	0.1111
p.R10S	DO49983	CESC	ICGC	DSGRKPS	DEG_SCF_TRCP1_1	0.1111
p.R27W	DO233111	GACA	ICGC	DSGRKPS	DEG_SCF_TRCP1_1	0.25
p.E13K	DO37474	SKCM	ICGC	DSGRKPS	DEG_SCF_TRCP1_1	0.1944
p.V26A	DO229253	THCA	ICGC	DSGRKPS	DEG_SCF_TRCP1_1	0.2778
p.R10H	ACH-000958	Colon/Colorectal Cancer	CCLE	DSGRKPS	DEG_SCF_TRCP1_1	0.1111
p.R10H	SW48	large_intestine	COSMIC	DSGRKPS	DEG_SCF_TRCP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JR98	Dynein light chain Tctex-type 4	DEG_SCF_TRCP1_1	18:24	DSGRKPS	BTRC	0.8951	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons