DegronMD - Q5JR98(DYNLT4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R27Q	TCGA-2W-A8YY	CESC	TCGA	PRGCLPSID	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.3056
p.R27Q	TCGA-2W-A8YY	CESC	TCGA	DSGRKPS	DEG_SCF_TRCP1_1	18:24	Mutation rewiring degron network	0.25
p.R27Q	DO223732	CESC	ICGC	PRGCLPSID	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.3056
p.R27Q	DO223732	CESC	ICGC	DSGRKPS	DEG_SCF_TRCP1_1	18:24	Mutation rewiring degron network	0.25
p.G44R	TCGA-2Y-A9H3	LIHC	TCGA	PRGCLPSID	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.1111
p.G44R	DO219525	LIHC	ICGC	PRGCLPSID	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.1111
p.R21W	TCGA-32-2616	GBM	TCGA	DSGRKPS	DEG_SCF_TRCP1_1	18:24	Mutation altering degron motif	0.7523
p.R21W	DO13462	GBM	ICGC	DSGRKPS	DEG_SCF_TRCP1_1	18:24	Mutation altering degron motif	0.7523
p.G9V	TCGA-DU-6404	LGG	TCGA	DSGRKPS	DEG_SCF_TRCP1_1	18:24	Mutation rewiring degron network	0.0833
p.G9V	DO22207	LGG	ICGC	DSGRKPS	DEG_SCF_TRCP1_1	18:24	Mutation rewiring degron network	0.0833
p.R27G	TCGA-EO-A22U	UCEC	TCGA	PRGCLPSID	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.3056
p.R27G	TCGA-EO-A22U	UCEC	TCGA	DSGRKPS	DEG_SCF_TRCP1_1	18:24	Mutation rewiring degron network	0.25
p.R27G	DO43755	UCEC	ICGC	PRGCLPSID	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.3056
p.R27G	DO43755	UCEC	ICGC	DSGRKPS	DEG_SCF_TRCP1_1	18:24	Mutation rewiring degron network	0.25
p.R10S	TCGA-Q1-A73P	CESC	TCGA	DSGRKPS	DEG_SCF_TRCP1_1	18:24	Mutation rewiring degron network	0.1111
p.R10S	DO49983	CESC	ICGC	DSGRKPS	DEG_SCF_TRCP1_1	18:24	Mutation rewiring degron network	0.1111
p.R27W	DO233111	GACA	ICGC	PRGCLPSID	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.3056
p.R27W	DO233111	GACA	ICGC	DSGRKPS	DEG_SCF_TRCP1_1	18:24	Mutation rewiring degron network	0.25
p.S34I	DO233652	GACA	ICGC	PRGCLPSID	DEG_APCC_DBOX_1	28:36	Mutation altering degron motif	0.623
p.I35T	DO232054	ORCA	ICGC	PRGCLPSID	DEG_APCC_DBOX_1	28:36	Mutation altering degron motif	0.7078
p.G88C	DO33552	PACA	ICGC	QRPSLGPVP	DEG_APCC_DBOX_1	77:85	Mutation rewiring degron network	0.25
p.R78Q	DO232761	PBCA	ICGC	QRPSLGPVP	DEG_APCC_DBOX_1	77:85	Mutation altering degron motif	0.7329
p.E13K	DO37474	SKCM	ICGC	DSGRKPS	DEG_SCF_TRCP1_1	18:24	Mutation rewiring degron network	0.1944
p.V26A	DO229253	THCA	ICGC	PRGCLPSID	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.2778
p.V26A	DO229253	THCA	ICGC	DSGRKPS	DEG_SCF_TRCP1_1	18:24	Mutation rewiring degron network	0.2778
p.L81P	DO229227	THCA	ICGC	QRPSLGPVP	DEG_APCC_DBOX_1	77:85	Mutation altering degron motif	0.7582
p.P79L	ACH-000281	Pancreatic Cancer	CCLE	QRPSLGPVP	DEG_APCC_DBOX_1	77:85	Mutation altering degron motif	0.6471
p.R10H	ACH-000958	Colon/Colorectal Cancer	CCLE	DSGRKPS	DEG_SCF_TRCP1_1	18:24	Mutation rewiring degron network	0.1111
p.R10H	SW48	large intestine	COSMIC	DSGRKPS	DEG_SCF_TRCP1_1	18:24	Mutation rewiring degron network	0.1111
p.P40R	ACH-001193	Bone Cancer	CCLE	PRGCLPSID	DEG_APCC_DBOX_1	28:36	Mutation rewiring degron network	0.2222

Kaplan plot for DYNLT4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DYNLT4

UniProt ID: Q5JR98

Entrez ID: 343521

Protein name: Dynein light chain Tctex-type 4 (Protein N22.1) (Tctex-2-beta) (Tctex1 domain-containing protein 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DYNLT4 in