DegronMD

Uniprot ID: Q5JR98

Source protein: Dynein light chain Tctex-type 4

Source gene: DYNLT4

Class: DEG_APCC_DBOX_1

Location: 28:36

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8136

ASA_SCORE: 91.2333

COIL: 0.8334

CONS_SCORE: 0.3212

DSS_SCORE: 0.7018

HELIX: 0.1402

FCONS_SCORE: 1.0825

RIG_SCORE: 0.6346

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R27Q	TCGA-2W-A8YY	CESC	TCGA	PRGCLPSID	DEG_APCC_DBOX_1	0.3056
p.R27Q	DO223732	CESC	ICGC	PRGCLPSID	DEG_APCC_DBOX_1	0.3056
p.G44R	TCGA-2Y-A9H3	LIHC	TCGA	PRGCLPSID	DEG_APCC_DBOX_1	0.1111
p.G44R	DO219525	LIHC	ICGC	PRGCLPSID	DEG_APCC_DBOX_1	0.1111
p.R27G	TCGA-EO-A22U	UCEC	TCGA	PRGCLPSID	DEG_APCC_DBOX_1	0.3056
p.R27G	DO43755	UCEC	ICGC	PRGCLPSID	DEG_APCC_DBOX_1	0.3056
p.R27W	DO233111	GACA	ICGC	PRGCLPSID	DEG_APCC_DBOX_1	0.3056
p.S34I	DO233652	GACA	ICGC	PRGCLPSID	DEG_APCC_DBOX_1	0.623
p.I35T	DO232054	ORCA	ICGC	PRGCLPSID	DEG_APCC_DBOX_1	0.7078
p.V26A	DO229253	THCA	ICGC	PRGCLPSID	DEG_APCC_DBOX_1	0.2778
p.P40R	ACH-001193	Bone Cancer	CCLE	PRGCLPSID	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JR98	Dynein light chain Tctex-type 4	DEG_APCC_DBOX_1	28:36	PRGCLPSID	APC,CDC20,FZR1	0.8136	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons