DegronMD

Uniprot ID: Q5JR98

Source protein: Dynein light chain Tctex-type 4

Source gene: DYNLT4

Class: DEG_APCC_DBOX_1

Location: 77:85

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9505

ASA_SCORE: 82.1778

COIL: 0.9296

CONS_SCORE: 0.3363

DSS_SCORE: 0.6187

HELIX: 0.0161

FCONS_SCORE: 0.9339

RIG_SCORE: 0.6042

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G88C	DO33552	PACA	ICGC	QRPSLGPVP	DEG_APCC_DBOX_1	0.25
p.R78Q	DO232761	PBCA	ICGC	QRPSLGPVP	DEG_APCC_DBOX_1	0.7329
p.L81P	DO229227	THCA	ICGC	QRPSLGPVP	DEG_APCC_DBOX_1	0.7582
p.P79L	ACH-000281	Pancreatic Cancer	CCLE	QRPSLGPVP	DEG_APCC_DBOX_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JR98	Dynein light chain Tctex-type 4	DEG_APCC_DBOX_1	77:85	QRPSLGPVP	APC,CDC20,FZR1	0.9505	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons