DegronMD

Uniprot ID: Q8TF76

Source protein: Serine/threonine-protein kinase haspin

Source gene: HASPIN

Class: DEG_SCF_TRCP1_1

Location: 142:147

E3 ligase: BTRC

DEGRON score: 0.9977

ASA_SCORE: 81.2833

COIL: 0.911

CONS_SCORE: 0.3301

DSS_SCORE: 0.5586

HELIX: 0.039

FCONS_SCORE: 1.0283

RIG_SCORE: 0.6118

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G154D	SIDM01007	T-Lymphoblastic Leukemia	GDSC	DSGRLS	DEG_SCF_TRCP1_1	0.1389
p.G154D	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	DSGRLS	DEG_SCF_TRCP1_1	0.1389
p.R134Q	SIDM01322	Oral Cavity Carcinoma	GDSC	DSGRLS	DEG_SCF_TRCP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TF76	Serine/threonine-protein kinase haspin	DEG_SCF_TRCP1_1	142:147	DSGRLS	BTRC	0.9977	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons