DegronMD - Q8TF76(HASPIN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P180L	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PTPRDS	DEG_SCF_FBW7_1	180:185	Mutation altering degron motif	0.6471
p.P180L	DND-41	haematopoietic and lymphoid tissue	COSMIC	PTPRDS	DEG_SCF_FBW7_1	180:185	Mutation altering degron motif	0.6471
p.G154D	SIDM01007	T-Lymphoblastic Leukemia	GDSC	DSGRLS	DEG_SCF_TRCP1_1	142:147	Mutation rewiring degron network	0.1389
p.G154D	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	DSGRLS	DEG_SCF_TRCP1_1	142:147	Mutation rewiring degron network	0.1389
p.I189T	SIDM00355	Non-Small Cell Lung Carcinoma	GDSC	PTPRDS	DEG_SCF_FBW7_1	180:185	Mutation rewiring degron network	0.2222
p.I189T	SIDM00235	Kidney Carcinoma	GDSC	PTPRDS	DEG_SCF_FBW7_1	180:185	Mutation rewiring degron network	0.2222
p.I189T	SIDM00271	Gastric Carcinoma	GDSC	PTPRDS	DEG_SCF_FBW7_1	180:185	Mutation rewiring degron network	0.2222
p.I189T	SIDM01622	Breast Carcinoma	GDSC	PTPRDS	DEG_SCF_FBW7_1	180:185	Mutation rewiring degron network	0.2222
p.I189T	SIDM01320	Pancreatic Carcinoma	GDSC	PTPRDS	DEG_SCF_FBW7_1	180:185	Mutation rewiring degron network	0.2222
p.I189T	SIDM01685	B-Lymphoblastic Leukemia	GDSC	PTPRDS	DEG_SCF_FBW7_1	180:185	Mutation rewiring degron network	0.2222
p.I189T	RCC10RGB	kidney	COSMIC	PTPRDS	DEG_SCF_FBW7_1	180:185	Mutation rewiring degron network	0.2222
p.I189T	MKN1	stomach	COSMIC	PTPRDS	DEG_SCF_FBW7_1	180:185	Mutation rewiring degron network	0.2222
p.I189T	RERF-LC-MS	lung	COSMIC	PTPRDS	DEG_SCF_FBW7_1	180:185	Mutation rewiring degron network	0.2222
p.S179T	SIDM01196	Hepatocellular Carcinoma	GDSC	PTPRDS	DEG_SCF_FBW7_1	180:185	Mutation blocking phosphorylation signal	0.75
p.S179T	SNU-475	liver	COSMIC	PTPRDS	DEG_SCF_FBW7_1	180:185	Mutation blocking phosphorylation signal	0.75
p.R134Q	SIDM01322	Oral Cavity Carcinoma	GDSC	DSGRLS	DEG_SCF_TRCP1_1	142:147	Mutation rewiring degron network	0.1111
p.S174L	SIDM01387	Small Cell Lung Carcinoma	GDSC	PTPRDS	DEG_SCF_FBW7_1	180:185	Mutation blocking phosphorylation signal	0.6111

Kaplan plot for HASPIN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HASPIN

UniProt ID: Q8TF76

Entrez ID: 83903

Protein name: Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HASPIN in