DegronMD

Uniprot ID: Q8TF76

Source protein: Serine/threonine-protein kinase haspin

Source gene: HASPIN

Class: DEG_SCF_FBW7_1

Location: 180:185

E3 ligase: FBXW7

DEGRON score: 0.8649

ASA_SCORE: 80.9167

COIL: 0.7622

CONS_SCORE: 0.2471

DSS_SCORE: 0.4014

HELIX: 0.2185

FCONS_SCORE: 0.973

RIG_SCORE: 0.6734

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P180L	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PTPRDS	DEG_SCF_FBW7_1	0.6471
p.P180L	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PTPRDS	DEG_SCF_FBW7_1	0.6471
p.I189T	SIDM00355	Non-Small Cell Lung Carcinoma	GDSC	PTPRDS	DEG_SCF_FBW7_1	0.2222
p.I189T	SIDM00235	Kidney Carcinoma	GDSC	PTPRDS	DEG_SCF_FBW7_1	0.2222
p.I189T	SIDM00271	Gastric Carcinoma	GDSC	PTPRDS	DEG_SCF_FBW7_1	0.2222
p.I189T	SIDM01622	Breast Carcinoma	GDSC	PTPRDS	DEG_SCF_FBW7_1	0.2222
p.I189T	SIDM01320	Pancreatic Carcinoma	GDSC	PTPRDS	DEG_SCF_FBW7_1	0.2222
p.I189T	SIDM01685	B-Lymphoblastic Leukemia	GDSC	PTPRDS	DEG_SCF_FBW7_1	0.2222
p.I189T	RCC10RGB	kidney	COSMIC	PTPRDS	DEG_SCF_FBW7_1	0.2222
p.I189T	MKN1	stomach	COSMIC	PTPRDS	DEG_SCF_FBW7_1	0.2222
p.I189T	RERF-LC-MS	lung	COSMIC	PTPRDS	DEG_SCF_FBW7_1	0.2222
p.S179T	SIDM01196	Hepatocellular Carcinoma	GDSC	PTPRDS	DEG_SCF_FBW7_1	0.75
p.S179T	SNU-475	liver	COSMIC	PTPRDS	DEG_SCF_FBW7_1	0.75
p.S174L	SIDM01387	Small Cell Lung Carcinoma	GDSC	PTPRDS	DEG_SCF_FBW7_1	0.6111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TF76	Serine/threonine-protein kinase haspin	DEG_SCF_FBW7_1	180:185	PTPRDS	FBXW7	0.8649	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons