DegronMD

Uniprot ID: Q6ZTW0

Source protein: Tubulin polyglutamylase complex subunit 1

Source gene: TPGS1

Class: DEG_SCF_TRCP1_1

Location: 19:24

E3 ligase: BTRC

DEGRON score: 0.9885

ASA_SCORE: 90.9167

COIL: 0.8568

CONS_SCORE: 0.3095

DSS_SCORE: 0.6013

HELIX: 0.1083

FCONS_SCORE: 1.0863

RIG_SCORE: 0.6541

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T18M	DO222718	COCA	ICGC	DSGRQS	DEG_SCF_TRCP1_1	0.3056
p.A29V	DO233855	GACA	ICGC	DSGRQS	DEG_SCF_TRCP1_1	0.1944
p.S20T	SIDM00987	Thyroid Gland Carcinoma	GDSC	DSGRQS	DEG_SCF_TRCP1_1	0.7116
p.S20T	ACH-000191	Thyroid Cancer	CCLE	DSGRQS	DEG_SCF_TRCP1_1	0.7116
p.P12L	SIDM00923	Cervical Carcinoma	GDSC	DSGRQS	DEG_SCF_TRCP1_1	0.1389
p.P12L	ACH-001336	Cervical Cancer	CCLE	DSGRQS	DEG_SCF_TRCP1_1	0.1389
p.A15S	ACH-000395	Lung Cancer	CCLE	DSGRQS	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZTW0	Tubulin polyglutamylase complex subunit 1	DEG_SCF_TRCP1_1	19:24	DSGRQS	BTRC	0.9885	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons