DegronMD

Uniprot ID: P10912

Source protein: Growth hormone receptor

Source gene: GHR

Class: DEG_SCF_TRCP1_1

Location: 383:388

E3 ligase: BTRC

DEGRON score: 0.8525

ASA_SCORE: 60.9333

COIL: 0.7988

CONS_SCORE: 0.6706

DSS_SCORE: 0.517

HELIX: 0.124

FCONS_SCORE: 1.0911

RIG_SCORE: 0.6278

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C390S	TCGA-24-2280	OV	TCGA	DSGRTS	DEG_SCF_TRCP1_1	0.2778
p.N376S	TCGA-AG-3592	READ	TCGA	DSGRTS	DEG_SCF_TRCP1_1	0.1389
p.S373P	TCGA-AX-A0J0	UCEC	TCGA	DSGRTS	DEG_SCF_TRCP1_1	0.0556
p.E396G	TCGA-BA-6870	HNSC	TCGA	DSGRTS	DEG_SCF_TRCP1_1	0.1111
p.R386H	TCGA-BJ-A0ZH	THCA	TCGA	DSGRTS	DEG_SCF_TRCP1_1	0.7133
p.D393N	TCGA-CQ-5327	HNSC	TCGA	DSGRTS	DEG_SCF_TRCP1_1	0.1944
p.G385E	TCGA-D6-A6EP	HNSC	TCGA	DSGRTS	DEG_SCF_TRCP1_1	0.7199
p.E391K	TCGA-FR-A3YO	SKCM	TCGA	DSGRTS	DEG_SCF_TRCP1_1	0.25
p.D398N	TCGA-GN-A266	SKCM	TCGA	DSGRTS	DEG_SCF_TRCP1_1	0.0556
p.G393R	DO49937	CESC	ICGC	DSGRTS	DEG_SCF_TRCP1_1	0.1944
p.P392T	DO230334	COCA	ICGC	DSGRTS	DEG_SCF_TRCP1_1	0.2222
p.P392T	DO229010	COCA	ICGC	DSGRTS	DEG_SCF_TRCP1_1	0.2222
p.P392T	DO229005	COCA	ICGC	DSGRTS	DEG_SCF_TRCP1_1	0.2222
p.P392T	DO230990	LUSC	ICGC	DSGRTS	DEG_SCF_TRCP1_1	0.2222
p.E376V	DO233862	GACA	ICGC	DSGRTS	DEG_SCF_TRCP1_1	0.1389
p.T381N	DO44448	HNSC	ICGC	DSGRTS	DEG_SCF_TRCP1_1	0.2778
p.L373I	DO45346	LUAD	ICGC	DSGRTS	DEG_SCF_TRCP1_1	0.0556
p.D377N	DO37483	SKCM	ICGC	DSGRTS	DEG_SCF_TRCP1_1	0.1667
p.R391M	DO40801	UCEC	ICGC	DSGRTS	DEG_SCF_TRCP1_1	0.25
p.E378K	SIDM00878	Breast Carcinoma	GDSC	DSGRTS	DEG_SCF_TRCP1_1	0.1944
p.E378K	HCC1569	breast	COSMIC	DSGRTS	DEG_SCF_TRCP1_1	0.1944
p.R393C	SIDM01739	Small Cell Lung Carcinoma	GDSC	DSGRTS	DEG_SCF_TRCP1_1	0.1944
p.R394M	ES7	bone	COSMIC	DSGRTS	DEG_SCF_TRCP1_1	0.1667
p.D381G	SNU-81	large_intestine	COSMIC	DSGRTS	DEG_SCF_TRCP1_1	0.2778
p.Q393R	H2795	pleura	COSMIC	DSGRTS	DEG_SCF_TRCP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10912	Growth hormone receptor	DEG_SCF_TRCP1_1	383:388	DSGRTS	BTRC	0.8525	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons