DegronMD - P10912(GHR)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.C390S	TCGA-24-2280	OV	TCGA	DSGRTS	DEG_SCF_TRCP1_1	383:388	Mutation rewiring degron network	0.2778
p.P604T	TCGA-39-5011	LUSC	TCGA	SEMPVPDY	DEG_COP1_1	588:595	Mutation rewiring degron network	0.0833
p.G504C	TCGA-49-AAR9	LUAD	TCGA	ITPAGS	DEG_SCF_FBW7_1	493:498	Mutation rewiring degron network	0.1667
p.V490L	TCGA-55-A490	LUAD	TCGA	ITPAGS	DEG_SCF_FBW7_1	493:498	Mutation rewiring degron network	0.25
p.M590L	TCGA-86-7953	LUAD	TCGA	SEMPVPDY	DEG_COP1_1	588:595	Mutation altering degron motif	0.5999
p.N376S	TCGA-AG-3592	READ	TCGA	DSGRTS	DEG_SCF_TRCP1_1	383:388	Mutation rewiring degron network	0.1389
p.S373P	TCGA-AX-A0J0	UCEC	TCGA	DSGRTS	DEG_SCF_TRCP1_1	383:388	Mutation rewiring degron network	0.0556
p.R578M	TCGA-AX-A3FT	UCEC	TCGA	SEMPVPDY	DEG_COP1_1	588:595	Mutation rewiring degron network	0.0556
p.E396G	TCGA-BA-6870	HNSC	TCGA	DSGRTS	DEG_SCF_TRCP1_1	383:388	Mutation rewiring degron network	0.1111
p.R386H	TCGA-BJ-A0ZH	THCA	TCGA	DSGRTS	DEG_SCF_TRCP1_1	383:388	Mutation altering degron motif	0.7133
p.P591L	TCGA-BR-8680	STAD	TCGA	SEMPVPDY	DEG_COP1_1	588:595	Mutation altering degron motif	0.6471
p.F486V	TCGA-CA-6717	COAD	TCGA	ITPAGS	DEG_SCF_FBW7_1	493:498	Mutation rewiring degron network	0.1389
p.D393N	TCGA-CQ-5327	HNSC	TCGA	DSGRTS	DEG_SCF_TRCP1_1	383:388	Mutation rewiring degron network	0.1944
p.G587S	TCGA-D3-A8GC	SKCM	TCGA	SEMPVPDY	DEG_COP1_1	588:595	Mutation rewiring degron network	0.3056
p.L501F	TCGA-D6-6516	HNSC	TCGA	ITPAGS	DEG_SCF_FBW7_1	493:498	Mutation rewiring degron network	0.25
p.G385E	TCGA-D6-A6EP	HNSC	TCGA	DSGRTS	DEG_SCF_TRCP1_1	383:388	Mutation altering degron motif	0.7199
p.G587C	TCGA-D9-A6EC	SKCM	TCGA	SEMPVPDY	DEG_COP1_1	588:595	Mutation rewiring degron network	0.3056
p.G504S	TCGA-EB-A3Y7	SKCM	TCGA	ITPAGS	DEG_SCF_FBW7_1	493:498	Mutation rewiring degron network	0.1667
p.D485N	TCGA-EE-A20H	SKCM	TCGA	ITPAGS	DEG_SCF_FBW7_1	493:498	Mutation rewiring degron network	0.1111
p.D485N	TCGA-ER-A19J	SKCM	TCGA	ITPAGS	DEG_SCF_FBW7_1	493:498	Mutation rewiring degron network	0.1111
p.G580R	TCGA-EK-A2GZ	CESC	TCGA	SEMPVPDY	DEG_COP1_1	588:595	Mutation rewiring degron network	0.1111
p.E391K	TCGA-FR-A3YO	SKCM	TCGA	DSGRTS	DEG_SCF_TRCP1_1	383:388	Mutation rewiring degron network	0.25
p.H599Y	TCGA-FW-A3R5	SKCM	TCGA	SEMPVPDY	DEG_COP1_1	588:595	Mutation rewiring degron network	0.2222
p.D398N	TCGA-GN-A266	SKCM	TCGA	DSGRTS	DEG_SCF_TRCP1_1	383:388	Mutation rewiring degron network	0.0556
p.E589D	TCGA-L9-A743	LUAD	TCGA	SEMPVPDY	DEG_COP1_1	588:595	Mutation altering degron motif	0.5647
p.S502F	TCGA-QB-A6FS	SKCM	TCGA	ITPAGS	DEG_SCF_FBW7_1	493:498	Mutation rewiring degron network	0.2222
p.G393R	DO49937	CESC	ICGC	DSGRTS	DEG_SCF_TRCP1_1	383:388	Mutation rewiring degron network	0.1944
p.P392T	DO230334	COCA	ICGC	DSGRTS	DEG_SCF_TRCP1_1	383:388	Mutation rewiring degron network	0.2222
p.P392T	DO229010	COCA	ICGC	DSGRTS	DEG_SCF_TRCP1_1	383:388	Mutation rewiring degron network	0.2222
p.P392T	DO229005	COCA	ICGC	DSGRTS	DEG_SCF_TRCP1_1	383:388	Mutation rewiring degron network	0.2222
p.P392T	DO230990	LUSC	ICGC	DSGRTS	DEG_SCF_TRCP1_1	383:388	Mutation rewiring degron network	0.2222
p.E376V	DO233862	GACA	ICGC	DSGRTS	DEG_SCF_TRCP1_1	383:388	Mutation rewiring degron network	0.1389
p.T381N	DO44448	HNSC	ICGC	DSGRTS	DEG_SCF_TRCP1_1	383:388	Mutation rewiring degron network	0.2778
p.L373I	DO45346	LUAD	ICGC	DSGRTS	DEG_SCF_TRCP1_1	383:388	Mutation rewiring degron network	0.0556
p.D377N	DO37483	SKCM	ICGC	DSGRTS	DEG_SCF_TRCP1_1	383:388	Mutation rewiring degron network	0.1667
p.R391M	DO40801	UCEC	ICGC	DSGRTS	DEG_SCF_TRCP1_1	383:388	Mutation rewiring degron network	0.25
p.S483R	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	ITPAGS	DEG_SCF_FBW7_1	493:498	Mutation rewiring degron network	0.0556
p.S483R	NCI-H1651	lung	COSMIC	ITPAGS	DEG_SCF_FBW7_1	493:498	Mutation rewiring degron network	0.0556
p.T581I	SIDM00238	Ovarian Carcinoma	GDSC	SEMPVPDY	DEG_COP1_1	588:595	Mutation rewiring degron network	0.1389
p.T581I	ACH-000962	Ovarian Cancer	CCLE	SEMPVPDY	DEG_COP1_1	588:595	Mutation rewiring degron network	0.1389
p.T581I	ACH-001145	Ovarian Cancer	CCLE	SEMPVPDY	DEG_COP1_1	588:595	Mutation rewiring degron network	0.1389
p.T581I	OC-314	ovary	COSMIC	SEMPVPDY	DEG_COP1_1	588:595	Mutation rewiring degron network	0.1389
p.T581I	OVK-18	ovary	COSMIC	SEMPVPDY	DEG_COP1_1	588:595	Mutation rewiring degron network	0.1389
p.E378K	SIDM00878	Breast Carcinoma	GDSC	DSGRTS	DEG_SCF_TRCP1_1	383:388	Mutation rewiring degron network	0.1944
p.E378K	HCC1569	breast	COSMIC	DSGRTS	DEG_SCF_TRCP1_1	383:388	Mutation rewiring degron network	0.1944
p.P502T	SIDM00596	Endometrial Carcinoma	GDSC	ITPAGS	DEG_SCF_FBW7_1	493:498	Mutation rewiring degron network	0.2222
p.P502T	SIDM00316	Glioblastoma	GDSC	ITPAGS	DEG_SCF_FBW7_1	493:498	Mutation rewiring degron network	0.2222
p.P502T	SIDM01551	Gastric Carcinoma	GDSC	ITPAGS	DEG_SCF_FBW7_1	493:498	Mutation rewiring degron network	0.2222
p.P502T	SIDM01347	Ovarian Carcinoma	GDSC	ITPAGS	DEG_SCF_FBW7_1	493:498	Mutation rewiring degron network	0.2222
p.P502T	SIDM00500	Colorectal Carcinoma	GDSC	ITPAGS	DEG_SCF_FBW7_1	493:498	Mutation rewiring degron network	0.2222
p.P598S	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	SEMPVPDY	DEG_COP1_1	588:595	Mutation rewiring degron network	0.25
p.P598S	NCI-H1155	lung	COSMIC	SEMPVPDY	DEG_COP1_1	588:595	Mutation rewiring degron network	0.25
p.V506G	SIDM01146	Gastric Carcinoma	GDSC	ITPAGS	DEG_SCF_FBW7_1	493:498	Mutation substituting flanking lysine	0.2222
p.V506G	NCI-SNU-1	stomach	COSMIC	ITPAGS	DEG_SCF_FBW7_1	493:498	Mutation substituting flanking lysine	0.2222
p.A495P	SIDM00793	Burkitt's Lymphoma	GDSC	ITPAGS	DEG_SCF_FBW7_1	493:498	Mutation altering degron motif	0.7503
p.A495P	EB-3	haematopoietic and lymphoid tissue	COSMIC	ITPAGS	DEG_SCF_FBW7_1	493:498	Mutation altering degron motif	0.7503
p.V599A	SIDM00534	Colorectal Carcinoma	GDSC	SEMPVPDY	DEG_COP1_1	588:595	Mutation rewiring degron network	0.2222
p.V599A	HT-115	large intestine	COSMIC	SEMPVPDY	DEG_COP1_1	588:595	Mutation rewiring degron network	0.2222
p.T588I	SIDM00220	Ovarian Carcinoma	GDSC	SEMPVPDY	DEG_COP1_1	588:595	Mutation altering degron motif	0.7078
p.T588I	OC-314	ovary	COSMIC	SEMPVPDY	DEG_COP1_1	588:595	Mutation altering degron motif	0.7078
p.R393C	SIDM01739	Small Cell Lung Carcinoma	GDSC	DSGRTS	DEG_SCF_TRCP1_1	383:388	Mutation rewiring degron network	0.1944
p.T588R	SIDM01575	Plasma Cell Myeloma	GDSC	SEMPVPDY	DEG_COP1_1	588:595	Mutation altering degron motif	0.7876
p.I491F	SIDM01690	Plasma Cell Myeloma	GDSC	ITPAGS	DEG_SCF_FBW7_1	493:498	Mutation rewiring degron network	0.2778
p.T581R	ACH-000426	Myeloma	CCLE	SEMPVPDY	DEG_COP1_1	588:595	Mutation rewiring degron network	0.1389
p.I484F	ACH-000453	Myeloma	CCLE	ITPAGS	DEG_SCF_FBW7_1	493:498	Mutation rewiring degron network	0.0833
p.F486C	ACH-000786	Lymphoma	CCLE	ITPAGS	DEG_SCF_FBW7_1	493:498	Mutation rewiring degron network	0.1389
p.S498V	ACH-000829	Myeloma	CCLE	ITPAGS	DEG_SCF_FBW7_1	493:498	Mutation altering degron motif	0.758
p.S498I	ACH-000829	Myeloma	CCLE	ITPAGS	DEG_SCF_FBW7_1	493:498	Mutation altering degron motif	0.7341
p.Q602K	ACH-000900	Lung Cancer	CCLE	SEMPVPDY	DEG_COP1_1	588:595	Mutation rewiring degron network	0.1389
p.Q602K	NCI-H23	lung	COSMIC	SEMPVPDY	DEG_COP1_1	588:595	Mutation rewiring degron network	0.1389
p.V499G	ACH-000932	Gastric Cancer	CCLE	ITPAGS	DEG_SCF_FBW7_1	493:498	Mutation rewiring degron network	0.3056
p.V499G	NCI-SNU-1	stomach	COSMIC	ITPAGS	DEG_SCF_FBW7_1	493:498	Mutation rewiring degron network	0.3056
p.P591S	ACH-000980	Lung Cancer	CCLE	SEMPVPDY	DEG_COP1_1	588:595	Mutation altering degron motif	0.5641
p.P591S	NCI-H1155	lung	COSMIC	SEMPVPDY	DEG_COP1_1	588:595	Mutation altering degron motif	0.5641
p.V592A	ACH-000986	Colon/Colorectal Cancer	CCLE	SEMPVPDY	DEG_COP1_1	588:595	Mutation altering degron motif	0.6936
p.V592A	HT-115	large intestine	COSMIC	SEMPVPDY	DEG_COP1_1	588:595	Mutation altering degron motif	0.6936
p.A488P	ACH-002236	Lymphoma	CCLE	ITPAGS	DEG_SCF_FBW7_1	493:498	Mutation rewiring degron network	0.1944
p.A488P	EB-3	haematopoietic and lymphoid tissue	COSMIC	ITPAGS	DEG_SCF_FBW7_1	493:498	Mutation rewiring degron network	0.1944
p.R394M	ES7	bone	COSMIC	DSGRTS	DEG_SCF_TRCP1_1	383:388	Mutation rewiring degron network	0.1667
p.L594F	EGI-1	biliary tract	COSMIC	SEMPVPDY	DEG_COP1_1	588:595	Mutation altering degron motif	0.6981
p.Q580K	NCI-H23	lung	COSMIC	SEMPVPDY	DEG_COP1_1	588:595	Mutation rewiring degron network	0.1111
p.D381G	SNU-81	large intestine	COSMIC	DSGRTS	DEG_SCF_TRCP1_1	383:388	Mutation rewiring degron network	0.2778
p.Y605N	ONS-76	central nervous system	COSMIC	SEMPVPDY	DEG_COP1_1	588:595	Mutation rewiring degron network	0.0556
p.Q393R	H2795	pleura	COSMIC	DSGRTS	DEG_SCF_TRCP1_1	383:388	Mutation rewiring degron network	0.1944
p.A589V	SNU-1040	large intestine	COSMIC	SEMPVPDY	DEG_COP1_1	588:595	Mutation altering degron motif	0.6936
p.L600I	HCC2998	large intestine	COSMIC	SEMPVPDY	DEG_COP1_1	588:595	Mutation rewiring degron network	0.1944

Kaplan plot for GHR in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GHR

UniProt ID: P10912

Entrez ID: 2690

Protein name: Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GHR in