DegronMD

Uniprot ID: P10912

Source protein: Growth hormone receptor

Source gene: GHR

Class: DEG_SCF_FBW7_1

Location: 493:498

E3 ligase: FBXW7

DEGRON score: 0.9435

ASA_SCORE: 48.85

COIL: 0.7183

CONS_SCORE: 0.7576

DSS_SCORE: 0.337

HELIX: 0.0417

FCONS_SCORE: 1.0346

RIG_SCORE: 0.7148

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G504C	TCGA-49-AAR9	LUAD	TCGA	ITPAGS	DEG_SCF_FBW7_1	0.1667
p.V490L	TCGA-55-A490	LUAD	TCGA	ITPAGS	DEG_SCF_FBW7_1	0.25
p.F486V	TCGA-CA-6717	COAD	TCGA	ITPAGS	DEG_SCF_FBW7_1	0.1389
p.L501F	TCGA-D6-6516	HNSC	TCGA	ITPAGS	DEG_SCF_FBW7_1	0.25
p.G504S	TCGA-EB-A3Y7	SKCM	TCGA	ITPAGS	DEG_SCF_FBW7_1	0.1667
p.D485N	TCGA-EE-A20H	SKCM	TCGA	ITPAGS	DEG_SCF_FBW7_1	0.1111
p.D485N	TCGA-ER-A19J	SKCM	TCGA	ITPAGS	DEG_SCF_FBW7_1	0.1111
p.S502F	TCGA-QB-A6FS	SKCM	TCGA	ITPAGS	DEG_SCF_FBW7_1	0.2222
p.S483R	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	ITPAGS	DEG_SCF_FBW7_1	0.0556
p.S483R	NCI-H1651	lung	COSMIC	ITPAGS	DEG_SCF_FBW7_1	0.0556
p.P502T	SIDM00596	Endometrial Carcinoma	GDSC	ITPAGS	DEG_SCF_FBW7_1	0.2222
p.P502T	SIDM00316	Glioblastoma	GDSC	ITPAGS	DEG_SCF_FBW7_1	0.2222
p.P502T	SIDM01551	Gastric Carcinoma	GDSC	ITPAGS	DEG_SCF_FBW7_1	0.2222
p.P502T	SIDM01347	Ovarian Carcinoma	GDSC	ITPAGS	DEG_SCF_FBW7_1	0.2222
p.P502T	SIDM00500	Colorectal Carcinoma	GDSC	ITPAGS	DEG_SCF_FBW7_1	0.2222
p.V506G	SIDM01146	Gastric Carcinoma	GDSC	ITPAGS	DEG_SCF_FBW7_1	0.2222
p.V506G	NCI-SNU-1	stomach	COSMIC	ITPAGS	DEG_SCF_FBW7_1	0.2222
p.A495P	SIDM00793	Burkitt's Lymphoma	GDSC	ITPAGS	DEG_SCF_FBW7_1	0.7503
p.A495P	EB-3	haematopoietic_and_lymphoid_tissue	COSMIC	ITPAGS	DEG_SCF_FBW7_1	0.7503
p.I491F	SIDM01690	Plasma Cell Myeloma	GDSC	ITPAGS	DEG_SCF_FBW7_1	0.2778
p.I484F	ACH-000453	Myeloma	CCLE	ITPAGS	DEG_SCF_FBW7_1	0.0833
p.F486C	ACH-000786	Lymphoma	CCLE	ITPAGS	DEG_SCF_FBW7_1	0.1389
p.S498V	ACH-000829	Myeloma	CCLE	ITPAGS	DEG_SCF_FBW7_1	0.758
p.S498I	ACH-000829	Myeloma	CCLE	ITPAGS	DEG_SCF_FBW7_1	0.7341
p.V499G	ACH-000932	Gastric Cancer	CCLE	ITPAGS	DEG_SCF_FBW7_1	0.3056
p.V499G	NCI-SNU-1	stomach	COSMIC	ITPAGS	DEG_SCF_FBW7_1	0.3056
p.A488P	ACH-002236	Lymphoma	CCLE	ITPAGS	DEG_SCF_FBW7_1	0.1944
p.A488P	EB-3	haematopoietic_and_lymphoid_tissue	COSMIC	ITPAGS	DEG_SCF_FBW7_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ITPAGS

Degron related mutations and impact score

Drug responses associated with GHR mutations

All proteins holding degron of ITPAGS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10912	Growth hormone receptor	DEG_SCF_FBW7_1	493:498	ITPAGS	FBXW7	0.9435	More...