DegronMD

Uniprot ID: P10912

Source protein: Growth hormone receptor

Source gene: GHR

Class: DEG_COP1_1

Location: 588:595

E3 ligase: COP1

DEGRON score: 0.9891

ASA_SCORE: 74.6625

COIL: 0.8064

CONS_SCORE: 0.6703

DSS_SCORE: 0.5368

HELIX: 0.0236

FCONS_SCORE: 1.5062

RIG_SCORE: 0.687

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P604T	TCGA-39-5011	LUSC	TCGA	SEMPVPDY	DEG_COP1_1	0.0833
p.M590L	TCGA-86-7953	LUAD	TCGA	SEMPVPDY	DEG_COP1_1	0.5999
p.R578M	TCGA-AX-A3FT	UCEC	TCGA	SEMPVPDY	DEG_COP1_1	0.0556
p.P591L	TCGA-BR-8680	STAD	TCGA	SEMPVPDY	DEG_COP1_1	0.6471
p.G587S	TCGA-D3-A8GC	SKCM	TCGA	SEMPVPDY	DEG_COP1_1	0.3056
p.G587C	TCGA-D9-A6EC	SKCM	TCGA	SEMPVPDY	DEG_COP1_1	0.3056
p.G580R	TCGA-EK-A2GZ	CESC	TCGA	SEMPVPDY	DEG_COP1_1	0.1111
p.H599Y	TCGA-FW-A3R5	SKCM	TCGA	SEMPVPDY	DEG_COP1_1	0.2222
p.E589D	TCGA-L9-A743	LUAD	TCGA	SEMPVPDY	DEG_COP1_1	0.5647
p.T581I	SIDM00238	Ovarian Carcinoma	GDSC	SEMPVPDY	DEG_COP1_1	0.1389
p.T581I	ACH-000962	Ovarian Cancer	CCLE	SEMPVPDY	DEG_COP1_1	0.1389
p.T581I	ACH-001145	Ovarian Cancer	CCLE	SEMPVPDY	DEG_COP1_1	0.1389
p.T581I	OC-314	ovary	COSMIC	SEMPVPDY	DEG_COP1_1	0.1389
p.T581I	OVK-18	ovary	COSMIC	SEMPVPDY	DEG_COP1_1	0.1389
p.P598S	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	SEMPVPDY	DEG_COP1_1	0.25
p.P598S	NCI-H1155	lung	COSMIC	SEMPVPDY	DEG_COP1_1	0.25
p.V599A	SIDM00534	Colorectal Carcinoma	GDSC	SEMPVPDY	DEG_COP1_1	0.2222
p.V599A	HT-115	large_intestine	COSMIC	SEMPVPDY	DEG_COP1_1	0.2222
p.T588I	SIDM00220	Ovarian Carcinoma	GDSC	SEMPVPDY	DEG_COP1_1	0.7078
p.T588I	OC-314	ovary	COSMIC	SEMPVPDY	DEG_COP1_1	0.7078
p.T588R	SIDM01575	Plasma Cell Myeloma	GDSC	SEMPVPDY	DEG_COP1_1	0.7876
p.T581R	ACH-000426	Myeloma	CCLE	SEMPVPDY	DEG_COP1_1	0.1389
p.Q602K	ACH-000900	Lung Cancer	CCLE	SEMPVPDY	DEG_COP1_1	0.1389
p.Q602K	NCI-H23	lung	COSMIC	SEMPVPDY	DEG_COP1_1	0.1389
p.P591S	ACH-000980	Lung Cancer	CCLE	SEMPVPDY	DEG_COP1_1	0.5641
p.P591S	NCI-H1155	lung	COSMIC	SEMPVPDY	DEG_COP1_1	0.5641
p.V592A	ACH-000986	Colon/Colorectal Cancer	CCLE	SEMPVPDY	DEG_COP1_1	0.6936
p.V592A	HT-115	large_intestine	COSMIC	SEMPVPDY	DEG_COP1_1	0.6936
p.L594F	EGI-1	biliary_tract	COSMIC	SEMPVPDY	DEG_COP1_1	0.6981
p.Q580K	NCI-H23	lung	COSMIC	SEMPVPDY	DEG_COP1_1	0.1111
p.Y605N	ONS-76	central_nervous_system	COSMIC	SEMPVPDY	DEG_COP1_1	0.0556
p.A589V	SNU-1040	large_intestine	COSMIC	SEMPVPDY	DEG_COP1_1	0.6936
p.L600I	HCC2998	large_intestine	COSMIC	SEMPVPDY	DEG_COP1_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SEMPVPDY

Degron related mutations and impact score

Drug responses associated with GHR mutations

All proteins holding degron of SEMPVPDY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10912	Growth hormone receptor	DEG_COP1_1	588:595	SEMPVPDY	COP1	0.9891	More...