DegronMD

Uniprot ID: Q13936

Source protein: Voltage-dependent L-type calcium channel subunit alpha-1C

Source gene: CACNA1C

Class: DEG_SCF_TRCP1_1

Location: 1878:1884

E3 ligase: BTRC

DEGRON score: 0.9062

ASA_SCORE: 71.8

COIL: 0.8777

CONS_SCORE: -1000

DSS_SCORE: 0.3423

HELIX: 0.1086

FCONS_SCORE: 1

RIG_SCORE: 0.6155

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1893K	DO228430	BRCA	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	0.1944
p.E1893K	DO228638	GACA	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	0.1944
p.E1893K	DO228752	GACA	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	0.1944
p.E1893K	DO227477	LAML	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	0.1944
p.E1893K	DO231090	LAML	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	0.1944
p.E1893K	DO228916	LICA	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	0.1944
p.E1893K	DO229047	LICA	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	0.1944
p.E1893K	DO229052	LICA	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	0.1944
p.E1893K	DO229006	LICA	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	0.1944
p.E1893K	DO224594	LUSC	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	0.1944
p.E1893K	DO224632	LUSC	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	0.1944
p.E1893K	DO222599	MELA	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	0.1944
p.E1893K	DO46560	OV	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	0.1944
p.E1893K	DO227727	PACA	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	0.1944
p.E1893K	DO37996	SKCM	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	0.1944
p.K1868N	DO229038	LICA	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	0.0556
p.G1872V	DO23282	LINC	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	0.1667
p.Q1890L	DO26025	LUAD	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	0.1667
p.M1886L	DO230524	LUSC	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	0.2778
p.P1876T	DO228338	MALY	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	0.2778
p.P1876T	ACH-002232	Lymphoma	CCLE	DSGSAGT	DEG_SCF_TRCP1_1	0.2778
p.P1876T	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	0.2778
p.S1868C	DO46761	PAEN	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	0.0556
p.L1887F	DO51275	SKCM	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	0.25
p.L1881M	DO42472	UCEC	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	0.711
p.E1873K	DO41331	UCEC	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	0.1944
p.A1871T	SIDM00789	Colorectal Carcinoma	GDSC	DSGSAGT	DEG_SCF_TRCP1_1	0.1389
p.A1871T	ACH-000997	Colon/Colorectal Cancer	CCLE	DSGSAGT	DEG_SCF_TRCP1_1	0.1389
p.A1871T	HCT-15	large_intestine	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	0.1389
p.E1883K	SIDM00312	Plasma Cell Myeloma	GDSC	DSGSAGT	DEG_SCF_TRCP1_1	0.7022
p.E1883K	ACH-000183	Myeloma	CCLE	DSGSAGT	DEG_SCF_TRCP1_1	0.7022
p.E1883K	L-363	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	0.7022
p.S1868F	ACH-000055	Brain Cancer	CCLE	DSGSAGT	DEG_SCF_TRCP1_1	0.0556
p.S1868F	D-283MED	central_nervous_system	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	0.0556
p.P1876S	ACH-000675	Lung Cancer	CCLE	DSGSAGT	DEG_SCF_TRCP1_1	0.2778
p.P1876S	NCI-H1734	lung	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	0.2778
p.P1882A	ACH-000988	Endometrial/Uterine Cancer	CCLE	DSGSAGT	DEG_SCF_TRCP1_1	0.7503
p.P1882A	MFE-319	endometrium	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	0.7503
p.E1878K	ACH-001568	Skin Cancer	CCLE	DSGSAGT	DEG_SCF_TRCP1_1	0.7022
p.P1883T	NCI-H446	lung	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	0.7031
p.L1879F	NUGC-3	stomach	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	0.6981
p.D1875H	OCI-M1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	0.25
p.E1876K	L-363	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	0.2778
p.L1874F	NUGC-3	stomach	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	0.2222
p.A1894T	HCT-15	large_intestine	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	0.0556
p.P1889T	NCI-H446	lung	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	0.1944
p.D1883H	OCI-M1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	0.7688
p.E1870K	L-363	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	0.1111
p.L1873F	NUGC-3	stomach	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	0.1944
p.A1891P	SJSA-1	bone	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	0.1389
p.L1888I	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	0.2222
p.D1894H	OCI-M1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	0.0556
p.L1894I	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	0.0556
p.L1889F	NUGC-3	stomach	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	0.1944
p.P1891T	NCI-H446	lung	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	0.1389
p.D1892H	OCI-M1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	0.1111
p.L1882F	NUGC-3	stomach	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	0.6981
p.D1881H	OCI-M1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	0.7688
p.L1871F	NUGC-3	stomach	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGSAGT

Degron related mutations and impact score

Drug responses associated with CACNA1C mutations

All proteins holding degron of DSGSAGT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	DEG_SCF_TRCP1_1	1878:1884	DSGSAGT	BTRC	0.9062	More...