DegronMD - Q13936(CACNA1C)

FUNCTION: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8392192, PubMed:7737988, PubMed:9087614, PubMed:9013606, PubMed:9607315, PubMed:12176756, PubMed:17071743, PubMed:11741969, PubMed:8099908, PubMed:12181424, PubMed:29078335, PubMed:29742403, PubMed:16299511, PubMed:20953164, PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506, PubMed:27218670, PubMed:23677916). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm (PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (PubMed:28119464). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable). {ECO:0000250|UniProtKB:P15381, ECO:0000269|PubMed:11741969, ECO:0000269|PubMed:12176756, ECO:0000269|PubMed:12181424, ECO:0000269|PubMed:15454078, ECO:0000269|PubMed:15863612, ECO:0000269|PubMed:16299511, ECO:0000269|PubMed:17071743, ECO:0000269|PubMed:17224476, ECO:0000269|PubMed:20953164, ECO:0000269|PubMed:23677916, ECO:0000269|PubMed:24728418, ECO:0000269|PubMed:26253506, ECO:0000269|PubMed:27218670, ECO:0000269|PubMed:28119464, ECO:0000269|PubMed:29078335, ECO:0000269|PubMed:29742403, ECO:0000269|PubMed:7737988, ECO:0000269|PubMed:8099908, ECO:0000269|PubMed:8392192, ECO:0000269|PubMed:9013606, ECO:0000269|PubMed:9087614, ECO:0000269|PubMed:9607315, ECO:0000305}.; FUNCTION: (Microbial infection) Acts as a receptor for Influenzavirus (PubMed:29779930). May play a critical role in allowing virus entry when sialylated and expressed on lung tissues (PubMed:29779930). {ECO:0000269|PubMed:29779930}. View more >>

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GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P2048H	TCGA-22-1012	LUSC	TCGA	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation rewiring degron network	0.1389
p.G2049D	TCGA-44-6776	LUAD	TCGA	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation rewiring degron network	0.1111
p.G2041V	TCGA-69-7979	LUAD	TCGA	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation altering degron motif	0.7532
p.G2024V	TCGA-78-7146	LUAD	TCGA	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation rewiring degron network	0.0556
p.N2032S	TCGA-BG-A222	UCEC	TCGA	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation rewiring degron network	0.2778
p.E2026K	TCGA-BT-A20R	BLCA	TCGA	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation rewiring degron network	0.1111
p.G2050S	TCGA-D3-A2JC	SKCM	TCGA	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation rewiring degron network	0.0833
p.S2027F	TCGA-D9-A1JW	SKCM	TCGA	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation rewiring degron network	0.1389
p.S2034N	TCGA-F7-A624	HNSC	TCGA	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation altering degron motif	0.7069
p.R2038I	DO447	BLCA	ICGC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation altering degron motif	0.8102
p.E1893K	DO228430	BRCA	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation substituting flanking lysine	0.1944
p.E1893K	DO228638	GACA	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation substituting flanking lysine	0.1944
p.E1893K	DO228752	GACA	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation substituting flanking lysine	0.1944
p.E1893K	DO227477	LAML	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation substituting flanking lysine	0.1944
p.E1893K	DO231090	LAML	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation substituting flanking lysine	0.1944
p.E1893K	DO228916	LICA	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation substituting flanking lysine	0.1944
p.E1893K	DO229047	LICA	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation substituting flanking lysine	0.1944
p.E1893K	DO229052	LICA	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation substituting flanking lysine	0.1944
p.E1893K	DO229006	LICA	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation substituting flanking lysine	0.1944
p.E1893K	DO224594	LUSC	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation substituting flanking lysine	0.1944
p.E1893K	DO224632	LUSC	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation substituting flanking lysine	0.1944
p.E1893K	DO222599	MELA	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation substituting flanking lysine	0.1944
p.E1893K	DO46560	OV	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation substituting flanking lysine	0.1944
p.E1893K	DO227727	PACA	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation substituting flanking lysine	0.1944
p.E1893K	DO37996	SKCM	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation substituting flanking lysine	0.1944
p.R2038T	DO2755	BRCA	ICGC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation altering degron motif	0.7876
p.A2035T	DO44230	BRCA	ICGC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation altering degron motif	0.7139
p.M2045V	DO14378	HNSC	ICGC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation rewiring degron network	0.2222
p.A2024S	DO229026	LICA	ICGC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation rewiring degron network	0.0556
p.K1868N	DO229038	LICA	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation rewiring degron network	0.0556
p.G1872V	DO23282	LINC	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation rewiring degron network	0.1667
p.R2040Q	DO45181	LIRI	ICGC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation altering degron motif	0.7329
p.Q2049H	DO218935	LUAD	ICGC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation rewiring degron network	0.1111
p.G2029D	DO24060	LUAD	ICGC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation rewiring degron network	0.1944
p.G2029D	DO222395	MELA	ICGC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation rewiring degron network	0.1944
p.Q1890L	DO26025	LUAD	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation rewiring degron network	0.1667
p.M1886L	DO230524	LUSC	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation rewiring degron network	0.2778
p.P2028H	DO27302	LUSC	ICGC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation rewiring degron network	0.1667
p.P1876T	DO228338	MALY	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation rewiring degron network	0.2778
p.P1876T	ACH-002232	Lymphoma	CCLE	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation rewiring degron network	0.2778
p.P1876T	DG-75	haematopoietic and lymphoid tissue	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation rewiring degron network	0.2778
p.P2041T	DO232009	ORCA	ICGC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation altering degron motif	0.7031
p.P2041T	SNU-1040	large intestine	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation altering degron motif	0.7031
p.A2050D	DO46657	PAAD	ICGC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation rewiring degron network	0.0833
p.R2038K	DO51479	PACA	ICGC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation altering degron motif	0.7237
p.V2042I	DO35484	PACA	ICGC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation rewiring degron network	0.3056
p.S1868C	DO46761	PAEN	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation rewiring degron network	0.0556
p.R2037Q	DO47343	SKCM	ICGC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation altering degron motif	0.7329
p.G2030S	DO47578	SKCM	ICGC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation rewiring degron network	0.2222
p.L1887F	DO51275	SKCM	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation rewiring degron network	0.25
p.L1881M	DO42472	UCEC	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation altering degron motif	0.711
p.E1873K	DO41331	UCEC	ICGC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation rewiring degron network	0.1944
p.G2041S	SIDM00845	Burkitt's Lymphoma	GDSC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation altering degron motif	0.6993
p.A2044S	SIDM00845	Burkitt's Lymphoma	GDSC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation rewiring degron network	0.25
p.P2048S	SIDM00698	Small Cell Lung Carcinoma	GDSC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation rewiring degron network	0.1389
p.P2048S	ACH-000506	Lung Cancer	CCLE	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation rewiring degron network	0.1389
p.P2048S	NCI-H146	lung	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation rewiring degron network	0.1389
p.A1871T	SIDM00789	Colorectal Carcinoma	GDSC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation rewiring degron network	0.1389
p.A1871T	ACH-000997	Colon/Colorectal Cancer	CCLE	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation rewiring degron network	0.1389
p.A1871T	HCT-15	large intestine	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation rewiring degron network	0.1389
p.T2046N	SIDM00936	Bladder Carcinoma	GDSC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation rewiring degron network	0.1944
p.T2046N	ACH-000142	Bladder Cancer	CCLE	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation rewiring degron network	0.1944
p.T2046N	CAL-29	urinary tract	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation rewiring degron network	0.1944
p.P2048T	SIDM00217	Colorectal Carcinoma	GDSC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation rewiring degron network	0.1389
p.P2048T	ACH-000999	Colon/Colorectal Cancer	CCLE	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation rewiring degron network	0.1389
p.P2048T	SNU-1040	large intestine	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation rewiring degron network	0.1389
p.E1883K	SIDM00312	Plasma Cell Myeloma	GDSC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation altering degron motif	0.7022
p.E1883K	ACH-000183	Myeloma	CCLE	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation altering degron motif	0.7022
p.E1883K	L-363	haematopoietic and lymphoid tissue	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation altering degron motif	0.7022
p.S1868F	ACH-000055	Brain Cancer	CCLE	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation rewiring degron network	0.0556
p.S1868F	D-283MED	central nervous system	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation rewiring degron network	0.0556
p.P1876S	ACH-000675	Lung Cancer	CCLE	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation rewiring degron network	0.2778
p.P1876S	NCI-H1734	lung	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation rewiring degron network	0.2778
p.P1882A	ACH-000988	Endometrial/Uterine Cancer	CCLE	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation altering degron motif	0.7503
p.P1882A	MFE-319	endometrium	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation altering degron motif	0.7503
p.E1878K	ACH-001568	Skin Cancer	CCLE	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation altering degron motif	0.7022
p.P1883T	NCI-H446	lung	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation altering degron motif	0.7031
p.P2047H	OSC-19	upper aerodigestive tract	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation rewiring degron network	0.1667
p.L1879F	NUGC-3	stomach	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation altering degron motif	0.6981
p.P2041S	NCI-H146	lung	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation altering degron motif	0.6752
p.P2036H	OSC-19	upper aerodigestive tract	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation altering degron motif	0.7694
p.D1875H	OCI-M1	haematopoietic and lymphoid tissue	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation rewiring degron network	0.25
p.E1876K	L-363	haematopoietic and lymphoid tissue	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation rewiring degron network	0.2778
p.L1874F	NUGC-3	stomach	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation rewiring degron network	0.2222
p.A1894T	HCT-15	large intestine	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation rewiring degron network	0.0556
p.P1889T	NCI-H446	lung	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation rewiring degron network	0.1944
p.D1883H	OCI-M1	haematopoietic and lymphoid tissue	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation altering degron motif	0.7688
p.P2035S	NCI-H146	lung	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation altering degron motif	0.6752
p.P2038H	OSC-19	upper aerodigestive tract	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation altering degron motif	0.7694
p.E1870K	L-363	haematopoietic and lymphoid tissue	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation rewiring degron network	0.1111
p.L1873F	NUGC-3	stomach	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation rewiring degron network	0.1944
p.P2035T	SNU-1040	large intestine	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation altering degron motif	0.7031
p.A1891P	SJSA-1	bone	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation rewiring degron network	0.1389
p.P2039H	OSC-19	upper aerodigestive tract	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation altering degron motif	0.6583
p.P2028T	SNU-1040	large intestine	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation rewiring degron network	0.1667
p.L1888I	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation rewiring degron network	0.2222
p.D1894H	OCI-M1	haematopoietic and lymphoid tissue	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation rewiring degron network	0.0556
p.P2027H	OSC-19	upper aerodigestive tract	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation rewiring degron network	0.1389
p.L1894I	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation rewiring degron network	0.0556
p.L1889F	NUGC-3	stomach	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation rewiring degron network	0.1944
p.Q2038H	H2722	pleura	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation altering degron motif	0.7582
p.T2033N	CAL-29	urinary tract	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation rewiring degron network	0.3056
p.P1891T	NCI-H446	lung	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation rewiring degron network	0.1389
p.D1892H	OCI-M1	haematopoietic and lymphoid tissue	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation rewiring degron network	0.1111
p.T2026N	CAL-29	urinary tract	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation rewiring degron network	0.1111
p.R2044W	SNU-175	large intestine	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation rewiring degron network	0.25
p.P2025T	SNU-1040	large intestine	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation rewiring degron network	0.0833
p.P2025S	NCI-H146	lung	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation rewiring degron network	0.0833
p.P2044H	OSC-19	upper aerodigestive tract	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation rewiring degron network	0.25
p.L1882F	NUGC-3	stomach	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation altering degron motif	0.6981
p.D1881H	OCI-M1	haematopoietic and lymphoid tissue	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation altering degron motif	0.7688
p.T2039N	CAL-29	urinary tract	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation altering degron motif	0.7055
p.L1871F	NUGC-3	stomach	COSMIC	DSGSAGT	DEG_SCF_TRCP1_1	1878:1884	Mutation rewiring degron network	0.1389
p.P2025H	OSC-19	upper aerodigestive tract	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation rewiring degron network	0.0833
p.P2028S	NCI-H146	lung	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	2034:2041	Mutation rewiring degron network	0.1667

Kaplan plot for CACNA1C in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CACNA1C

UniProt ID: Q13936

Entrez ID: 775

Protein name: Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Voltage-gated calcium channel subunit alpha Cav1.2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CACNA1C in