DegronMD

Uniprot ID: Q13936

Source protein: Voltage-dependent L-type calcium channel subunit alpha-1C

Source gene: CACNA1C

Class: DEG_SCF_FBW7_1

Location: 2034:2041

E3 ligase: FBXW7

DEGRON score: 0.9985

ASA_SCORE: 72.3125

COIL: 0.9545

CONS_SCORE: 0.3377

DSS_SCORE: 0.6472

HELIX: 0.0183

FCONS_SCORE: 1.2822

RIG_SCORE: 0.5821

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2048H	TCGA-22-1012	LUSC	TCGA	PFATPPAT	DEG_SCF_FBW7_1	0.1389
p.G2049D	TCGA-44-6776	LUAD	TCGA	PFATPPAT	DEG_SCF_FBW7_1	0.1111
p.G2041V	TCGA-69-7979	LUAD	TCGA	PFATPPAT	DEG_SCF_FBW7_1	0.7532
p.G2024V	TCGA-78-7146	LUAD	TCGA	PFATPPAT	DEG_SCF_FBW7_1	0.0556
p.N2032S	TCGA-BG-A222	UCEC	TCGA	PFATPPAT	DEG_SCF_FBW7_1	0.2778
p.E2026K	TCGA-BT-A20R	BLCA	TCGA	PFATPPAT	DEG_SCF_FBW7_1	0.1111
p.G2050S	TCGA-D3-A2JC	SKCM	TCGA	PFATPPAT	DEG_SCF_FBW7_1	0.0833
p.S2027F	TCGA-D9-A1JW	SKCM	TCGA	PFATPPAT	DEG_SCF_FBW7_1	0.1389
p.S2034N	TCGA-F7-A624	HNSC	TCGA	PFATPPAT	DEG_SCF_FBW7_1	0.7069
p.R2038I	DO447	BLCA	ICGC	PFATPPAT	DEG_SCF_FBW7_1	0.8102
p.R2038T	DO2755	BRCA	ICGC	PFATPPAT	DEG_SCF_FBW7_1	0.7876
p.A2035T	DO44230	BRCA	ICGC	PFATPPAT	DEG_SCF_FBW7_1	0.7139
p.M2045V	DO14378	HNSC	ICGC	PFATPPAT	DEG_SCF_FBW7_1	0.2222
p.A2024S	DO229026	LICA	ICGC	PFATPPAT	DEG_SCF_FBW7_1	0.0556
p.R2040Q	DO45181	LIRI	ICGC	PFATPPAT	DEG_SCF_FBW7_1	0.7329
p.Q2049H	DO218935	LUAD	ICGC	PFATPPAT	DEG_SCF_FBW7_1	0.1111
p.G2029D	DO24060	LUAD	ICGC	PFATPPAT	DEG_SCF_FBW7_1	0.1944
p.G2029D	DO222395	MELA	ICGC	PFATPPAT	DEG_SCF_FBW7_1	0.1944
p.P2028H	DO27302	LUSC	ICGC	PFATPPAT	DEG_SCF_FBW7_1	0.1667
p.P2041T	DO232009	ORCA	ICGC	PFATPPAT	DEG_SCF_FBW7_1	0.7031
p.P2041T	SNU-1040	large_intestine	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	0.7031
p.A2050D	DO46657	PAAD	ICGC	PFATPPAT	DEG_SCF_FBW7_1	0.0833
p.R2038K	DO51479	PACA	ICGC	PFATPPAT	DEG_SCF_FBW7_1	0.7237
p.V2042I	DO35484	PACA	ICGC	PFATPPAT	DEG_SCF_FBW7_1	0.3056
p.R2037Q	DO47343	SKCM	ICGC	PFATPPAT	DEG_SCF_FBW7_1	0.7329
p.G2030S	DO47578	SKCM	ICGC	PFATPPAT	DEG_SCF_FBW7_1	0.2222
p.G2041S	SIDM00845	Burkitt's Lymphoma	GDSC	PFATPPAT	DEG_SCF_FBW7_1	0.6993
p.A2044S	SIDM00845	Burkitt's Lymphoma	GDSC	PFATPPAT	DEG_SCF_FBW7_1	0.25
p.P2048S	SIDM00698	Small Cell Lung Carcinoma	GDSC	PFATPPAT	DEG_SCF_FBW7_1	0.1389
p.P2048S	ACH-000506	Lung Cancer	CCLE	PFATPPAT	DEG_SCF_FBW7_1	0.1389
p.P2048S	NCI-H146	lung	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	0.1389
p.T2046N	SIDM00936	Bladder Carcinoma	GDSC	PFATPPAT	DEG_SCF_FBW7_1	0.1944
p.T2046N	ACH-000142	Bladder Cancer	CCLE	PFATPPAT	DEG_SCF_FBW7_1	0.1944
p.T2046N	CAL-29	urinary_tract	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	0.1944
p.P2048T	SIDM00217	Colorectal Carcinoma	GDSC	PFATPPAT	DEG_SCF_FBW7_1	0.1389
p.P2048T	ACH-000999	Colon/Colorectal Cancer	CCLE	PFATPPAT	DEG_SCF_FBW7_1	0.1389
p.P2048T	SNU-1040	large_intestine	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	0.1389
p.P2047H	OSC-19	upper_aerodigestive_tract	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	0.1667
p.P2041S	NCI-H146	lung	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	0.6752
p.P2036H	OSC-19	upper_aerodigestive_tract	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	0.7694
p.P2035S	NCI-H146	lung	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	0.6752
p.P2038H	OSC-19	upper_aerodigestive_tract	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	0.7694
p.P2035T	SNU-1040	large_intestine	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	0.7031
p.P2039H	OSC-19	upper_aerodigestive_tract	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	0.6583
p.P2028T	SNU-1040	large_intestine	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	0.1667
p.P2027H	OSC-19	upper_aerodigestive_tract	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	0.1389
p.Q2038H	H2722	pleura	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	0.7582
p.T2033N	CAL-29	urinary_tract	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	0.3056
p.T2026N	CAL-29	urinary_tract	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	0.1111
p.R2044W	SNU-175	large_intestine	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	0.25
p.P2025T	SNU-1040	large_intestine	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	0.0833
p.P2025S	NCI-H146	lung	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	0.0833
p.P2044H	OSC-19	upper_aerodigestive_tract	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	0.25
p.T2039N	CAL-29	urinary_tract	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	0.7055
p.P2025H	OSC-19	upper_aerodigestive_tract	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	0.0833
p.P2028S	NCI-H146	lung	COSMIC	PFATPPAT	DEG_SCF_FBW7_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PFATPPAT

Degron related mutations and impact score

Drug responses associated with CACNA1C mutations

All proteins holding degron of PFATPPAT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13936	Voltage-dependent L-type calcium channel subunit alpha-1C	DEG_SCF_FBW7_1	2034:2041	PFATPPAT	FBXW7	0.9985	More...