DegronMD

Uniprot ID: Q9UPR3

Source protein: Nonsense-mediated mRNA decay factor SMG5

Source gene: SMG5

Class: DEG_SCF_TRCP1_1

Location: 494:500

E3 ligase: BTRC

DEGRON score: 0.9352

ASA_SCORE: 90.1714

COIL: 0.8873

CONS_SCORE: 0.4092

DSS_SCORE: 0.7308

HELIX: 0.0846

FCONS_SCORE: 1.0746

RIG_SCORE: 0.5271

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S495R	TCGA-23-2078	OV	TCGA	DSGSDKS	DEG_SCF_TRCP1_1	0.8538
p.S495R	DO31829	OV	ICGC	DSGSDKS	DEG_SCF_TRCP1_1	0.8538
p.S495N	TCGA-23-2078	OV	TCGA	DSGSDKS	DEG_SCF_TRCP1_1	0.818
p.S495N	DO31829	OV	ICGC	DSGSDKS	DEG_SCF_TRCP1_1	0.818
p.D494G	TCGA-34-8455	LUSC	TCGA	DSGSDKS	DEG_SCF_TRCP1_1	0.7198
p.D494G	DO50095	LUSC	ICGC	DSGSDKS	DEG_SCF_TRCP1_1	0.7198
p.T506M	TCGA-BR-6566	STAD	TCGA	DSGSDKS	DEG_SCF_TRCP1_1	0.1667
p.T506M	TCGA-CD-A4MJ	STAD	TCGA	DSGSDKS	DEG_SCF_TRCP1_1	0.1667
p.T506M	DO47811	STAD	ICGC	DSGSDKS	DEG_SCF_TRCP1_1	0.1667
p.T506M	DO38217	STAD	ICGC	DSGSDKS	DEG_SCF_TRCP1_1	0.1667
p.S497F	TCGA-BR-6801	STAD	TCGA	DSGSDKS	DEG_SCF_TRCP1_1	0.7982
p.S497F	DO38253	STAD	ICGC	DSGSDKS	DEG_SCF_TRCP1_1	0.7982
p.R488Q	TCGA-BS-A0UV	UCEC	TCGA	DSGSDKS	DEG_SCF_TRCP1_1	0.1667
p.R488Q	DO42793	UCEC	ICGC	DSGSDKS	DEG_SCF_TRCP1_1	0.1667
p.L501F	TCGA-VQ-AA68	STAD	TCGA	DSGSDKS	DEG_SCF_TRCP1_1	0.3056
p.L501F	DO51799	STAD	ICGC	DSGSDKS	DEG_SCF_TRCP1_1	0.3056
p.A489V	DO51144	PRAD	ICGC	DSGSDKS	DEG_SCF_TRCP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPR3	Nonsense-mediated mRNA decay factor SMG5	DEG_SCF_TRCP1_1	494:500	DSGSDKS	BTRC	0.9352	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons