DegronMD - Q9UPR3(SMG5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S495R	TCGA-23-2078	OV	TCGA	DSGSDKS	DEG_SCF_TRCP1_1	494:500	Mutation altering degron motif	0.8538
p.S495R	DO31829	OV	ICGC	DSGSDKS	DEG_SCF_TRCP1_1	494:500	Mutation altering degron motif	0.8538
p.S495N	TCGA-23-2078	OV	TCGA	DSGSDKS	DEG_SCF_TRCP1_1	494:500	Mutation altering degron motif	0.818
p.S495N	DO31829	OV	ICGC	DSGSDKS	DEG_SCF_TRCP1_1	494:500	Mutation altering degron motif	0.818
p.P537L	TCGA-28-2506	GBM	TCGA	SRSDLEDME	DEG_APCC_DBOX_1	521:529	Mutation rewiring degron network	0.1111
p.P537L	DO11585	GBM	ICGC	SRSDLEDME	DEG_APCC_DBOX_1	521:529	Mutation rewiring degron network	0.1111
p.D494G	TCGA-34-8455	LUSC	TCGA	DSGSDKS	DEG_SCF_TRCP1_1	494:500	Mutation altering degron motif	0.7198
p.D494G	DO50095	LUSC	ICGC	DSGSDKS	DEG_SCF_TRCP1_1	494:500	Mutation altering degron motif	0.7198
p.S514L	TCGA-90-A4ED	LUSC	TCGA	SRSDLEDME	DEG_APCC_DBOX_1	521:529	Mutation rewiring degron network	0.1389
p.S514L	DO45482	LUSC	ICGC	SRSDLEDME	DEG_APCC_DBOX_1	521:529	Mutation rewiring degron network	0.1389
p.R522Q	TCGA-B5-A0JY	UCEC	TCGA	SRSDLEDME	DEG_APCC_DBOX_1	521:529	Mutation altering degron motif	0.7329
p.R522Q	DO43041	UCEC	ICGC	SRSDLEDME	DEG_APCC_DBOX_1	521:529	Mutation altering degron motif	0.7329
p.T506M	TCGA-BR-6566	STAD	TCGA	DSGSDKS	DEG_SCF_TRCP1_1	494:500	Mutation rewiring degron network	0.1667
p.T506M	TCGA-CD-A4MJ	STAD	TCGA	DSGSDKS	DEG_SCF_TRCP1_1	494:500	Mutation rewiring degron network	0.1667
p.T506M	DO47811	STAD	ICGC	DSGSDKS	DEG_SCF_TRCP1_1	494:500	Mutation rewiring degron network	0.1667
p.T506M	DO38217	STAD	ICGC	DSGSDKS	DEG_SCF_TRCP1_1	494:500	Mutation rewiring degron network	0.1667
p.S497F	TCGA-BR-6801	STAD	TCGA	DSGSDKS	DEG_SCF_TRCP1_1	494:500	Mutation altering degron motif	0.7982
p.S497F	DO38253	STAD	ICGC	DSGSDKS	DEG_SCF_TRCP1_1	494:500	Mutation altering degron motif	0.7982
p.R488Q	TCGA-BS-A0UV	UCEC	TCGA	DSGSDKS	DEG_SCF_TRCP1_1	494:500	Mutation rewiring degron network	0.1667
p.R488Q	DO42793	UCEC	ICGC	DSGSDKS	DEG_SCF_TRCP1_1	494:500	Mutation rewiring degron network	0.1667
p.M516I	TCGA-DK-AA6Q	BLCA	TCGA	SRSDLEDME	DEG_APCC_DBOX_1	521:529	Mutation rewiring degron network	0.1944
p.M516I	DO219005	BLCA	ICGC	SRSDLEDME	DEG_APCC_DBOX_1	521:529	Mutation rewiring degron network	0.1944
p.L501F	TCGA-VQ-AA68	STAD	TCGA	DSGSDKS	DEG_SCF_TRCP1_1	494:500	Mutation rewiring degron network	0.3056
p.L501F	DO51799	STAD	ICGC	DSGSDKS	DEG_SCF_TRCP1_1	494:500	Mutation rewiring degron network	0.3056
p.A489V	DO51144	PRAD	ICGC	DSGSDKS	DEG_SCF_TRCP1_1	494:500	Mutation rewiring degron network	0.1944
p.P537S	SIDM00434	Plasma Cell Myeloma	GDSC	SRSDLEDME	DEG_APCC_DBOX_1	521:529	Mutation rewiring degron network	0.1111
p.P537S	ACH-000745	Myeloma	CCLE	SRSDLEDME	DEG_APCC_DBOX_1	521:529	Mutation rewiring degron network	0.1111
p.P537S	MOLP-8	haematopoietic and lymphoid tissue	COSMIC	SRSDLEDME	DEG_APCC_DBOX_1	521:529	Mutation rewiring degron network	0.1111
p.T534I	SIDM00555	Glioblastoma	GDSC	SRSDLEDME	DEG_APCC_DBOX_1	521:529	Mutation rewiring degron network	0.1944
p.T534I	ACH-000631	Brain Cancer	CCLE	SRSDLEDME	DEG_APCC_DBOX_1	521:529	Mutation rewiring degron network	0.1944
p.T534I	KS-1	central nervous system	COSMIC	SRSDLEDME	DEG_APCC_DBOX_1	521:529	Mutation rewiring degron network	0.1944

Kaplan plot for SMG5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SMG5

UniProt ID: Q9UPR3

Entrez ID: 23381

Protein name: Nonsense-mediated mRNA decay factor SMG5 (EST1-like protein B) (LPTS-RP1) (LPTS-interacting protein) (SMG-5 homolog) (hSMG-5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SMG5 in