DegronMD

Uniprot ID: Q9UPR3

Source protein: Nonsense-mediated mRNA decay factor SMG5

Source gene: SMG5

Class: DEG_APCC_DBOX_1

Location: 521:529

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9796

ASA_SCORE: 93.3333

COIL: 0.5821

CONS_SCORE: 0.4512

DSS_SCORE: 0.8822

HELIX: 0.382

FCONS_SCORE: 1.225

RIG_SCORE: 0.6333

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P537L	TCGA-28-2506	GBM	TCGA	SRSDLEDME	DEG_APCC_DBOX_1	0.1111
p.P537L	DO11585	GBM	ICGC	SRSDLEDME	DEG_APCC_DBOX_1	0.1111
p.S514L	TCGA-90-A4ED	LUSC	TCGA	SRSDLEDME	DEG_APCC_DBOX_1	0.1389
p.S514L	DO45482	LUSC	ICGC	SRSDLEDME	DEG_APCC_DBOX_1	0.1389
p.R522Q	TCGA-B5-A0JY	UCEC	TCGA	SRSDLEDME	DEG_APCC_DBOX_1	0.7329
p.R522Q	DO43041	UCEC	ICGC	SRSDLEDME	DEG_APCC_DBOX_1	0.7329
p.M516I	TCGA-DK-AA6Q	BLCA	TCGA	SRSDLEDME	DEG_APCC_DBOX_1	0.1944
p.M516I	DO219005	BLCA	ICGC	SRSDLEDME	DEG_APCC_DBOX_1	0.1944
p.P537S	SIDM00434	Plasma Cell Myeloma	GDSC	SRSDLEDME	DEG_APCC_DBOX_1	0.1111
p.P537S	ACH-000745	Myeloma	CCLE	SRSDLEDME	DEG_APCC_DBOX_1	0.1111
p.P537S	MOLP-8	haematopoietic_and_lymphoid_tissue	COSMIC	SRSDLEDME	DEG_APCC_DBOX_1	0.1111
p.T534I	SIDM00555	Glioblastoma	GDSC	SRSDLEDME	DEG_APCC_DBOX_1	0.1944
p.T534I	ACH-000631	Brain Cancer	CCLE	SRSDLEDME	DEG_APCC_DBOX_1	0.1944
p.T534I	KS-1	central_nervous_system	COSMIC	SRSDLEDME	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPR3	Nonsense-mediated mRNA decay factor SMG5	DEG_APCC_DBOX_1	521:529	SRSDLEDME	APC,CDC20,FZR1	0.9796	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons