DegronMD

Uniprot ID: Q14137

Source protein: Ribosome biogenesis protein BOP1

Source gene: BOP1

Class: DEG_SCF_TRCP1_1

Location: 65:71

E3 ligase: BTRC

DEGRON score: 0.9335

ASA_SCORE: 86.9429

COIL: 0.9261

CONS_SCORE: 0.2889

DSS_SCORE: 0.8812

HELIX: 0.0536

FCONS_SCORE: 1.0566

RIG_SCORE: 0.528

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D74N	TCGA-2Y-A9H4	LIHC	TCGA	DSGSDSS	DEG_SCF_TRCP1_1	0.25
p.D65Y	TCGA-37-3783	LUSC	TCGA	DSGSDSS	DEG_SCF_TRCP1_1	0.7325
p.D65Y	DO26734	LUSC	ICGC	DSGSDSS	DEG_SCF_TRCP1_1	0.7325
p.D73Y	TCGA-55-A492	LUAD	TCGA	DSGSDSS	DEG_SCF_TRCP1_1	0.2778
p.D73Y	DO23708	LUAD	ICGC	DSGSDSS	DEG_SCF_TRCP1_1	0.2778
p.G67S	TCGA-AP-A0LS	UCEC	TCGA	DSGSDSS	DEG_SCF_TRCP1_1	0.6993
p.G67S	DO43178	UCEC	ICGC	DSGSDSS	DEG_SCF_TRCP1_1	0.6993
p.E76K	TCGA-AR-A0TZ	BRCA	TCGA	DSGSDSS	DEG_SCF_TRCP1_1	0.1944
p.E76K	TCGA-S5-A6DX	BLCA	TCGA	DSGSDSS	DEG_SCF_TRCP1_1	0.1944
p.E76K	DO51903	BLCA	ICGC	DSGSDSS	DEG_SCF_TRCP1_1	0.1944
p.E76K	DO2287	BRCA	ICGC	DSGSDSS	DEG_SCF_TRCP1_1	0.1944
p.E76K	ACH-001411	Bladder Cancer	CCLE	DSGSDSS	DEG_SCF_TRCP1_1	0.1944
p.D78N	TCGA-BT-A20J	BLCA	TCGA	DSGSDSS	DEG_SCF_TRCP1_1	0.1389
p.D78N	DO457	BLCA	ICGC	DSGSDSS	DEG_SCF_TRCP1_1	0.1389
p.D78N	DO33084	PACA	ICGC	DSGSDSS	DEG_SCF_TRCP1_1	0.1389
p.E79K	TCGA-FW-A3R5	SKCM	TCGA	DSGSDSS	DEG_SCF_TRCP1_1	0.1111
p.E79K	DO37406	SKCM	ICGC	DSGSDSS	DEG_SCF_TRCP1_1	0.1111
p.S70N	TCGA-IB-7651	PAAD	TCGA	DSGSDSS	DEG_SCF_TRCP1_1	0.5958
p.S70N	DO46657	PAAD	ICGC	DSGSDSS	DEG_SCF_TRCP1_1	0.5958
p.T62I	ACH-000140	Lymphoma	CCLE	DSGSDSS	DEG_SCF_TRCP1_1	0.25
p.T62I	ACH-000571	Brain Cancer	CCLE	DSGSDSS	DEG_SCF_TRCP1_1	0.25
p.T62I	ACH-000931	Skin Cancer	CCLE	DSGSDSS	DEG_SCF_TRCP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14137	Ribosome biogenesis protein BOP1	DEG_SCF_TRCP1_1	65:71	DSGSDSS	BTRC	0.9335	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons