DegronMD - Q14137(BOP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D74N	TCGA-2Y-A9H4	LIHC	TCGA	DSGSDSS	DEG_SCF_TRCP1_1	65:71	Mutation rewiring degron network	0.25
p.D65Y	TCGA-37-3783	LUSC	TCGA	DSGSDSS	DEG_SCF_TRCP1_1	65:71	Mutation altering degron motif	0.7325
p.D65Y	DO26734	LUSC	ICGC	DSGSDSS	DEG_SCF_TRCP1_1	65:71	Mutation altering degron motif	0.7325
p.D73Y	TCGA-55-A492	LUAD	TCGA	DSGSDSS	DEG_SCF_TRCP1_1	65:71	Mutation rewiring degron network	0.2778
p.D73Y	DO23708	LUAD	ICGC	DSGSDSS	DEG_SCF_TRCP1_1	65:71	Mutation rewiring degron network	0.2778
p.S48R	TCGA-69-7765	LUAD	TCGA	DSGVSDS	DEG_SCF_TRCP1_1	49:55	Mutation rewiring degron network	0.3056
p.S48R	DO23580	LUAD	ICGC	DSGVSDS	DEG_SCF_TRCP1_1	49:55	Mutation rewiring degron network	0.3056
p.G67S	TCGA-AP-A0LS	UCEC	TCGA	DSGSDSS	DEG_SCF_TRCP1_1	65:71	Mutation altering degron motif	0.6993
p.G67S	DO43178	UCEC	ICGC	DSGSDSS	DEG_SCF_TRCP1_1	65:71	Mutation altering degron motif	0.6993
p.E76K	TCGA-AR-A0TZ	BRCA	TCGA	DSGSDSS	DEG_SCF_TRCP1_1	65:71	Mutation rewiring degron network	0.1944
p.E76K	TCGA-S5-A6DX	BLCA	TCGA	DSGSDSS	DEG_SCF_TRCP1_1	65:71	Mutation rewiring degron network	0.1944
p.E76K	DO51903	BLCA	ICGC	DSGSDSS	DEG_SCF_TRCP1_1	65:71	Mutation rewiring degron network	0.1944
p.E76K	DO2287	BRCA	ICGC	DSGSDSS	DEG_SCF_TRCP1_1	65:71	Mutation rewiring degron network	0.1944
p.E76K	ACH-001411	Bladder Cancer	CCLE	DSGSDSS	DEG_SCF_TRCP1_1	65:71	Mutation rewiring degron network	0.1944
p.G47S	TCGA-BR-8361	STAD	TCGA	DSGVSDS	DEG_SCF_TRCP1_1	49:55	Mutation rewiring degron network	0.2778
p.G47S	DO48032	STAD	ICGC	DSGVSDS	DEG_SCF_TRCP1_1	49:55	Mutation rewiring degron network	0.2778
p.D78N	TCGA-BT-A20J	BLCA	TCGA	DSGSDSS	DEG_SCF_TRCP1_1	65:71	Mutation rewiring degron network	0.1389
p.D78N	DO457	BLCA	ICGC	DSGSDSS	DEG_SCF_TRCP1_1	65:71	Mutation rewiring degron network	0.1389
p.D78N	DO33084	PACA	ICGC	DSGSDSS	DEG_SCF_TRCP1_1	65:71	Mutation rewiring degron network	0.1389
p.S53C	TCGA-C4-A0F7	BLCA	TCGA	DSGVSDS	DEG_SCF_TRCP1_1	49:55	Mutation altering degron motif	0.643
p.V52I	TCGA-CM-6162	COAD	TCGA	DSGVSDS	DEG_SCF_TRCP1_1	49:55	Mutation altering degron motif	0.5965
p.V52I	DO8479	COAD	ICGC	DSGVSDS	DEG_SCF_TRCP1_1	49:55	Mutation altering degron motif	0.5965
p.V52I	DO23328	LINC	ICGC	DSGVSDS	DEG_SCF_TRCP1_1	49:55	Mutation altering degron motif	0.5965
p.S53F	TCGA-DA-A95Z	SKCM	TCGA	DSGVSDS	DEG_SCF_TRCP1_1	49:55	Mutation altering degron motif	0.6871
p.S53F	DO219481	SKCM	ICGC	DSGVSDS	DEG_SCF_TRCP1_1	49:55	Mutation altering degron motif	0.6871
p.E79K	TCGA-FW-A3R5	SKCM	TCGA	DSGSDSS	DEG_SCF_TRCP1_1	65:71	Mutation rewiring degron network	0.1111
p.E79K	DO37406	SKCM	ICGC	DSGSDSS	DEG_SCF_TRCP1_1	65:71	Mutation rewiring degron network	0.1111
p.S70N	TCGA-IB-7651	PAAD	TCGA	DSGSDSS	DEG_SCF_TRCP1_1	65:71	Mutation altering degron motif	0.5958
p.S70N	DO46657	PAAD	ICGC	DSGSDSS	DEG_SCF_TRCP1_1	65:71	Mutation altering degron motif	0.5958
p.T62I	ACH-000140	Lymphoma	CCLE	DSGVSDS	DEG_SCF_TRCP1_1	49:55	Mutation rewiring degron network	0.1389
p.T62I	ACH-000140	Lymphoma	CCLE	DSGSDSS	DEG_SCF_TRCP1_1	65:71	Mutation rewiring degron network	0.25
p.T62I	ACH-000571	Brain Cancer	CCLE	DSGVSDS	DEG_SCF_TRCP1_1	49:55	Mutation rewiring degron network	0.1389
p.T62I	ACH-000571	Brain Cancer	CCLE	DSGSDSS	DEG_SCF_TRCP1_1	65:71	Mutation rewiring degron network	0.25
p.T62I	ACH-000931	Skin Cancer	CCLE	DSGVSDS	DEG_SCF_TRCP1_1	49:55	Mutation rewiring degron network	0.1389
p.T62I	ACH-000931	Skin Cancer	CCLE	DSGSDSS	DEG_SCF_TRCP1_1	65:71	Mutation rewiring degron network	0.25

Kaplan plot for BOP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BOP1

UniProt ID: Q14137

Entrez ID: 23246

Protein name: Ribosome biogenesis protein BOP1 (Block of proliferation 1 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BOP1 in