DegronMD

Uniprot ID: Q14137

Source protein: Ribosome biogenesis protein BOP1

Source gene: BOP1

Class: DEG_SCF_TRCP1_1

Location: 49:55

E3 ligase: BTRC

DEGRON score: 0.9833

ASA_SCORE: 80.4143

COIL: 0.9077

CONS_SCORE: 0.2615

DSS_SCORE: 0.773

HELIX: 0.0539

FCONS_SCORE: 0.9874

RIG_SCORE: 0.5514

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S48R	TCGA-69-7765	LUAD	TCGA	DSGVSDS	DEG_SCF_TRCP1_1	0.3056
p.S48R	DO23580	LUAD	ICGC	DSGVSDS	DEG_SCF_TRCP1_1	0.3056
p.G47S	TCGA-BR-8361	STAD	TCGA	DSGVSDS	DEG_SCF_TRCP1_1	0.2778
p.G47S	DO48032	STAD	ICGC	DSGVSDS	DEG_SCF_TRCP1_1	0.2778
p.S53C	TCGA-C4-A0F7	BLCA	TCGA	DSGVSDS	DEG_SCF_TRCP1_1	0.643
p.V52I	TCGA-CM-6162	COAD	TCGA	DSGVSDS	DEG_SCF_TRCP1_1	0.5965
p.V52I	DO8479	COAD	ICGC	DSGVSDS	DEG_SCF_TRCP1_1	0.5965
p.V52I	DO23328	LINC	ICGC	DSGVSDS	DEG_SCF_TRCP1_1	0.5965
p.S53F	TCGA-DA-A95Z	SKCM	TCGA	DSGVSDS	DEG_SCF_TRCP1_1	0.6871
p.S53F	DO219481	SKCM	ICGC	DSGVSDS	DEG_SCF_TRCP1_1	0.6871
p.T62I	ACH-000140	Lymphoma	CCLE	DSGVSDS	DEG_SCF_TRCP1_1	0.1389
p.T62I	ACH-000571	Brain Cancer	CCLE	DSGVSDS	DEG_SCF_TRCP1_1	0.1389
p.T62I	ACH-000931	Skin Cancer	CCLE	DSGVSDS	DEG_SCF_TRCP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14137	Ribosome biogenesis protein BOP1	DEG_SCF_TRCP1_1	49:55	DSGVSDS	BTRC	0.9833	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons