DegronMD

Uniprot ID: Q9UKJ3

Source protein: G patch domain-containing protein 8

Source gene: GPATCH8

Class: DEG_SCF_TRCP1_1

Location: 844:850

E3 ligase: BTRC

DEGRON score: 0.9653

ASA_SCORE: 95.3

COIL: 0.8181

CONS_SCORE: 0.533

DSS_SCORE: 0.7281

HELIX: 0.1761

FCONS_SCORE: 1.0784

RIG_SCORE: 0.5006

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S847I	TCGA-69-7763	LUAD	TCGA	DSGSEHS	DEG_SCF_TRCP1_1	0.7341
p.R853C	TCGA-CG-5721	STAD	TCGA	DSGSEHS	DEG_SCF_TRCP1_1	0.25
p.S856Y	TCGA-CG-5733	STAD	TCGA	DSGSEHS	DEG_SCF_TRCP1_1	0.1667
p.R851C	TCGA-EO-A22U	UCEC	TCGA	DSGSEHS	DEG_SCF_TRCP1_1	0.3056
p.D837G	DO219023	BLCA	ICGC	DSGSEHS	DEG_SCF_TRCP1_1	0.5833
p.D834Y	DO230346	COCA	ICGC	DSGSEHS	DEG_SCF_TRCP1_1	0.0556
p.S845L	DO48240	ESCA	ICGC	DSGSEHS	DEG_SCF_TRCP1_1	0.8778
p.D855N	DO228585	LICA	ICGC	DSGSEHS	DEG_SCF_TRCP1_1	0.1944
p.H848Q	DO228978	LICA	ICGC	DSGSEHS	DEG_SCF_TRCP1_1	0.7582
p.L859I	DO229036	LICA	ICGC	DSGSEHS	DEG_SCF_TRCP1_1	0.0833
p.Y857C	DO52314	LIHC	ICGC	DSGSEHS	DEG_SCF_TRCP1_1	0.1389
p.K849N	DO45225	LIRI	ICGC	DSGSEHS	DEG_SCF_TRCP1_1	0.6918
p.H848Y	DO50097	LUSC	ICGC	DSGSEHS	DEG_SCF_TRCP1_1	0.7229
p.D835V	DO219784	UCEC	ICGC	DSGSEHS	DEG_SCF_TRCP1_1	0.0833
p.E841D	SIDM01117	Small Cell Lung Carcinoma	GDSC	DSGSEHS	DEG_SCF_TRCP1_1	0.25
p.E841D	ACH-002176	Lung Cancer	CCLE	DSGSEHS	DEG_SCF_TRCP1_1	0.25
p.E841D	NCI-H748	lung	COSMIC	DSGSEHS	DEG_SCF_TRCP1_1	0.25
p.R853H	SIDM00849	Kidney Carcinoma	GDSC	DSGSEHS	DEG_SCF_TRCP1_1	0.25
p.R853H	SIDM01686	Chronic Myelogenous Leukemia	GDSC	DSGSEHS	DEG_SCF_TRCP1_1	0.25
p.R851G	ACH-000296	Colon/Colorectal Cancer	CCLE	DSGSEHS	DEG_SCF_TRCP1_1	0.3056
p.R851G	ACH-001609	Brain Cancer	CCLE	DSGSEHS	DEG_SCF_TRCP1_1	0.3056
p.Y836H	ACH-000993	Endometrial/Uterine Cancer	CCLE	DSGSEHS	DEG_SCF_TRCP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKJ3	G patch domain-containing protein 8	DEG_SCF_TRCP1_1	844:850	DSGSEHS	BTRC	0.9653	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons