DegronMD - Q9UKJ3(GPATCH8)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D1218N	TCGA-4Z-AA7R	BLCA	TCGA	PLGTPAHS	DEG_SCF_FBW7_1	1223:1230	Mutation rewiring degron network	0.1944
p.S847I	TCGA-69-7763	LUAD	TCGA	DSGSEHS	DEG_SCF_TRCP1_1	844:850	Mutation altering degron motif	0.7341
p.I1359M	TCGA-75-5126	LUAD	TCGA	LAPATPALQPIHI	DEG_ODPH_VHL_1	1349:1361	Mutation altering degron motif	0.6507
p.A1345V	TCGA-A5-A0G2	UCEC	TCGA	LAPATPALQPIHI	DEG_ODPH_VHL_1	1349:1361	Mutation rewiring degron network	0.2222
p.L1349M	TCGA-AJ-A3EK	UCEC	TCGA	LAPATPALQPIHI	DEG_ODPH_VHL_1	1349:1361	Mutation altering degron motif	0.711
p.A1352S	TCGA-B5-A11E	UCEC	TCGA	LAPATPALQPIHI	DEG_ODPH_VHL_1	1349:1361	Mutation altering degron motif	0.6477
p.R853C	TCGA-CG-5721	STAD	TCGA	DSGSEHS	DEG_SCF_TRCP1_1	844:850	Mutation rewiring degron network	0.25
p.S856Y	TCGA-CG-5733	STAD	TCGA	DSGSEHS	DEG_SCF_TRCP1_1	844:850	Mutation rewiring degron network	0.1667
p.R851C	TCGA-EO-A22U	UCEC	TCGA	DSGSEHS	DEG_SCF_TRCP1_1	844:850	Mutation rewiring degron network	0.3056
p.P1344Q	TCGA-G4-6294	COAD	TCGA	LAPATPALQPIHI	DEG_ODPH_VHL_1	1349:1361	Mutation rewiring degron network	0.1944
p.D837G	DO219023	BLCA	ICGC	DSGSEHS	DEG_SCF_TRCP1_1	844:850	Mutation blocking phosphorylation signal	0.5833
p.A1353V	DO10582	COAD	ICGC	LAPATPALQPIHI	DEG_ODPH_VHL_1	1349:1361	Mutation altering degron motif	0.6936
p.A1353V	DO8786	COAD	ICGC	LAPATPALQPIHI	DEG_ODPH_VHL_1	1349:1361	Mutation altering degron motif	0.6936
p.G1350V	DO230326	COCA	ICGC	LAPATPALQPIHI	DEG_ODPH_VHL_1	1349:1361	Mutation altering degron motif	0.7532
p.D834Y	DO230346	COCA	ICGC	DSGSEHS	DEG_SCF_TRCP1_1	844:850	Mutation rewiring degron network	0.0556
p.S845L	DO48240	ESCA	ICGC	DSGSEHS	DEG_SCF_TRCP1_1	844:850	Mutation altering degron motif	0.8778
p.A1225V	DO233944	GACA	ICGC	PLGTPAHS	DEG_SCF_FBW7_1	1223:1230	Mutation altering degron motif	0.6936
p.A1225V	DO232761	PBCA	ICGC	PLGTPAHS	DEG_SCF_FBW7_1	1223:1230	Mutation altering degron motif	0.6936
p.A1225V	DO38619	STAD	ICGC	PLGTPAHS	DEG_SCF_FBW7_1	1223:1230	Mutation altering degron motif	0.6936
p.D855N	DO228585	LICA	ICGC	DSGSEHS	DEG_SCF_TRCP1_1	844:850	Mutation rewiring degron network	0.1944
p.P1236H	DO228908	LICA	ICGC	PLGTPAHS	DEG_SCF_FBW7_1	1223:1230	Mutation rewiring degron network	0.1667
p.H848Q	DO228978	LICA	ICGC	DSGSEHS	DEG_SCF_TRCP1_1	844:850	Mutation altering degron motif	0.7582
p.H1342N	DO229025	LICA	ICGC	LAPATPALQPIHI	DEG_ODPH_VHL_1	1349:1361	Mutation rewiring degron network	0.1389
p.H1342N	DO37627	SKCM	ICGC	LAPATPALQPIHI	DEG_ODPH_VHL_1	1349:1361	Mutation rewiring degron network	0.1389
p.H1362N	DO229027	LICA	ICGC	LAPATPALQPIHI	DEG_ODPH_VHL_1	1349:1361	Mutation rewiring degron network	0.3056
p.P1231T	DO229032	LICA	ICGC	PLGTPAHS	DEG_SCF_FBW7_1	1223:1230	Mutation rewiring degron network	0.3056
p.L859I	DO229036	LICA	ICGC	DSGSEHS	DEG_SCF_TRCP1_1	844:850	Mutation rewiring degron network	0.0833
p.E1238D	DO50890	LICA	ICGC	PLGTPAHS	DEG_SCF_FBW7_1	1223:1230	Mutation rewiring degron network	0.1111
p.Y857C	DO52314	LIHC	ICGC	DSGSEHS	DEG_SCF_TRCP1_1	844:850	Mutation rewiring degron network	0.1389
p.K849N	DO45225	LIRI	ICGC	DSGSEHS	DEG_SCF_TRCP1_1	844:850	Mutation altering degron motif	0.6918
p.H848Y	DO50097	LUSC	ICGC	DSGSEHS	DEG_SCF_TRCP1_1	844:850	Mutation altering degron motif	0.7229
p.A1357T	DO228168	PBCA	ICGC	LAPATPALQPIHI	DEG_ODPH_VHL_1	1349:1361	Mutation altering degron motif	0.7139
p.A1357T	DO38815	STAD	ICGC	LAPATPALQPIHI	DEG_ODPH_VHL_1	1349:1361	Mutation altering degron motif	0.7139
p.P1236L	DO47282	SKCM	ICGC	PLGTPAHS	DEG_SCF_FBW7_1	1223:1230	Mutation rewiring degron network	0.1667
p.P1352S	DO48618	SKCM	ICGC	LAPATPALQPIHI	DEG_ODPH_VHL_1	1349:1361	Mutation altering degron motif	0.6752
p.D835V	DO219784	UCEC	ICGC	DSGSEHS	DEG_SCF_TRCP1_1	844:850	Mutation rewiring degron network	0.0833
p.S1339Y	DO41379	UCEC	ICGC	LAPATPALQPIHI	DEG_ODPH_VHL_1	1349:1361	Mutation rewiring degron network	0.0556
p.Q1362E	SIDM01117	Small Cell Lung Carcinoma	GDSC	LAPATPALQPIHI	DEG_ODPH_VHL_1	1349:1361	Mutation rewiring degron network	0.3056
p.Q1362E	ACH-002176	Lung Cancer	CCLE	LAPATPALQPIHI	DEG_ODPH_VHL_1	1349:1361	Mutation rewiring degron network	0.3056
p.Q1362E	NCI-H748	lung	COSMIC	LAPATPALQPIHI	DEG_ODPH_VHL_1	1349:1361	Mutation rewiring degron network	0.3056
p.E841D	SIDM01117	Small Cell Lung Carcinoma	GDSC	DSGSEHS	DEG_SCF_TRCP1_1	844:850	Mutation rewiring degron network	0.25
p.E841D	ACH-002176	Lung Cancer	CCLE	DSGSEHS	DEG_SCF_TRCP1_1	844:850	Mutation rewiring degron network	0.25
p.E841D	NCI-H748	lung	COSMIC	DSGSEHS	DEG_SCF_TRCP1_1	844:850	Mutation rewiring degron network	0.25
p.D1236G	SIDM01113	Other Sarcomas	GDSC	PLGTPAHS	DEG_SCF_FBW7_1	1223:1230	Mutation rewiring degron network	0.1667
p.D1236G	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	PLGTPAHS	DEG_SCF_FBW7_1	1223:1230	Mutation rewiring degron network	0.1667
p.D1236G	SK-UT-1	soft tissue	COSMIC	PLGTPAHS	DEG_SCF_FBW7_1	1223:1230	Mutation rewiring degron network	0.1667
p.D1236G	NCI-H1793	lung	COSMIC	PLGTPAHS	DEG_SCF_FBW7_1	1223:1230	Mutation rewiring degron network	0.1667
p.R853H	SIDM00849	Kidney Carcinoma	GDSC	DSGSEHS	DEG_SCF_TRCP1_1	844:850	Mutation rewiring degron network	0.25
p.R853H	SIDM01686	Chronic Myelogenous Leukemia	GDSC	DSGSEHS	DEG_SCF_TRCP1_1	844:850	Mutation rewiring degron network	0.25
p.A1217V	SIDM00217	Colorectal Carcinoma	GDSC	PLGTPAHS	DEG_SCF_FBW7_1	1223:1230	Mutation rewiring degron network	0.1667
p.A1217V	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PLGTPAHS	DEG_SCF_FBW7_1	1223:1230	Mutation rewiring degron network	0.1667
p.A1217V	ACH-000942	Leukemia	CCLE	PLGTPAHS	DEG_SCF_FBW7_1	1223:1230	Mutation rewiring degron network	0.1667
p.A1217V	ACH-000999	Colon/Colorectal Cancer	CCLE	PLGTPAHS	DEG_SCF_FBW7_1	1223:1230	Mutation rewiring degron network	0.1667
p.A1217V	SNU-1040	large intestine	COSMIC	PLGTPAHS	DEG_SCF_FBW7_1	1223:1230	Mutation rewiring degron network	0.1667
p.K1341R	SIDM00901	Endometrial Carcinoma	GDSC	LAPATPALQPIHI	DEG_ODPH_VHL_1	1349:1361	Mutation blocking ubiquitination signal	0.5556
p.K1341R	ACH-000940	Endometrial/Uterine Cancer	CCLE	LAPATPALQPIHI	DEG_ODPH_VHL_1	1349:1361	Mutation blocking ubiquitination signal	0.5556
p.K1341R	AN3-CA	endometrium	COSMIC	LAPATPALQPIHI	DEG_ODPH_VHL_1	1349:1361	Mutation blocking ubiquitination signal	0.5556
p.A1347V	SIDM01608	Endometrial Carcinoma	GDSC	LAPATPALQPIHI	DEG_ODPH_VHL_1	1349:1361	Mutation rewiring degron network	0.2778
p.A1347V	ACH-000990	Endometrial/Uterine Cancer	CCLE	LAPATPALQPIHI	DEG_ODPH_VHL_1	1349:1361	Mutation rewiring degron network	0.2778
p.R851G	ACH-000296	Colon/Colorectal Cancer	CCLE	DSGSEHS	DEG_SCF_TRCP1_1	844:850	Mutation rewiring degron network	0.3056
p.R851G	ACH-001609	Brain Cancer	CCLE	DSGSEHS	DEG_SCF_TRCP1_1	844:850	Mutation rewiring degron network	0.3056
p.Y836H	ACH-000993	Endometrial/Uterine Cancer	CCLE	DSGSEHS	DEG_SCF_TRCP1_1	844:850	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GPATCH8

UniProt ID: Q9UKJ3

Entrez ID: 23131

Protein name: G patch domain-containing protein 8

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GPATCH8 in