DegronMD

Uniprot ID: Q9UKJ3

Source protein: G patch domain-containing protein 8

Source gene: GPATCH8

Class: DEG_SCF_FBW7_1

Location: 1223:1230

E3 ligase: FBXW7

DEGRON score: 0.9766

ASA_SCORE: 84.6875

COIL: 0.9399

CONS_SCORE: 0.5018

DSS_SCORE: 0.6494

HELIX: 0.0329

FCONS_SCORE: 0.9985

RIG_SCORE: 0.5974

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1218N	TCGA-4Z-AA7R	BLCA	TCGA	PLGTPAHS	DEG_SCF_FBW7_1	0.1944
p.A1225V	DO233944	GACA	ICGC	PLGTPAHS	DEG_SCF_FBW7_1	0.6936
p.A1225V	DO232761	PBCA	ICGC	PLGTPAHS	DEG_SCF_FBW7_1	0.6936
p.A1225V	DO38619	STAD	ICGC	PLGTPAHS	DEG_SCF_FBW7_1	0.6936
p.P1236H	DO228908	LICA	ICGC	PLGTPAHS	DEG_SCF_FBW7_1	0.1667
p.P1231T	DO229032	LICA	ICGC	PLGTPAHS	DEG_SCF_FBW7_1	0.3056
p.E1238D	DO50890	LICA	ICGC	PLGTPAHS	DEG_SCF_FBW7_1	0.1111
p.P1236L	DO47282	SKCM	ICGC	PLGTPAHS	DEG_SCF_FBW7_1	0.1667
p.D1236G	SIDM01113	Other Sarcomas	GDSC	PLGTPAHS	DEG_SCF_FBW7_1	0.1667
p.D1236G	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	PLGTPAHS	DEG_SCF_FBW7_1	0.1667
p.D1236G	SK-UT-1	soft_tissue	COSMIC	PLGTPAHS	DEG_SCF_FBW7_1	0.1667
p.D1236G	NCI-H1793	lung	COSMIC	PLGTPAHS	DEG_SCF_FBW7_1	0.1667
p.A1217V	SIDM00217	Colorectal Carcinoma	GDSC	PLGTPAHS	DEG_SCF_FBW7_1	0.1667
p.A1217V	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PLGTPAHS	DEG_SCF_FBW7_1	0.1667
p.A1217V	ACH-000942	Leukemia	CCLE	PLGTPAHS	DEG_SCF_FBW7_1	0.1667
p.A1217V	ACH-000999	Colon/Colorectal Cancer	CCLE	PLGTPAHS	DEG_SCF_FBW7_1	0.1667
p.A1217V	SNU-1040	large_intestine	COSMIC	PLGTPAHS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKJ3	G patch domain-containing protein 8	DEG_SCF_FBW7_1	1223:1230	PLGTPAHS	FBXW7	0.9766	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons