DegronMD

Uniprot ID: Q9UKJ3

Source protein: G patch domain-containing protein 8

Source gene: GPATCH8

Class: DEG_ODPH_VHL_1

Location: 1349:1361

E3 ligase: VHL

DEGRON score: 0.9632

ASA_SCORE: 92.3154

COIL: 0.9392

CONS_SCORE: 0.5082

DSS_SCORE: 0.3499

HELIX: 0.0215

FCONS_SCORE: 0.97

RIG_SCORE: 0.7341

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1359M	TCGA-75-5126	LUAD	TCGA	LAPATPALQPIHI	DEG_ODPH_VHL_1	0.6507
p.A1345V	TCGA-A5-A0G2	UCEC	TCGA	LAPATPALQPIHI	DEG_ODPH_VHL_1	0.2222
p.L1349M	TCGA-AJ-A3EK	UCEC	TCGA	LAPATPALQPIHI	DEG_ODPH_VHL_1	0.711
p.A1352S	TCGA-B5-A11E	UCEC	TCGA	LAPATPALQPIHI	DEG_ODPH_VHL_1	0.6477
p.P1344Q	TCGA-G4-6294	COAD	TCGA	LAPATPALQPIHI	DEG_ODPH_VHL_1	0.1944
p.A1353V	DO10582	COAD	ICGC	LAPATPALQPIHI	DEG_ODPH_VHL_1	0.6936
p.A1353V	DO8786	COAD	ICGC	LAPATPALQPIHI	DEG_ODPH_VHL_1	0.6936
p.G1350V	DO230326	COCA	ICGC	LAPATPALQPIHI	DEG_ODPH_VHL_1	0.7532
p.H1342N	DO229025	LICA	ICGC	LAPATPALQPIHI	DEG_ODPH_VHL_1	0.1389
p.H1342N	DO37627	SKCM	ICGC	LAPATPALQPIHI	DEG_ODPH_VHL_1	0.1389
p.H1362N	DO229027	LICA	ICGC	LAPATPALQPIHI	DEG_ODPH_VHL_1	0.3056
p.A1357T	DO228168	PBCA	ICGC	LAPATPALQPIHI	DEG_ODPH_VHL_1	0.7139
p.A1357T	DO38815	STAD	ICGC	LAPATPALQPIHI	DEG_ODPH_VHL_1	0.7139
p.P1352S	DO48618	SKCM	ICGC	LAPATPALQPIHI	DEG_ODPH_VHL_1	0.6752
p.S1339Y	DO41379	UCEC	ICGC	LAPATPALQPIHI	DEG_ODPH_VHL_1	0.0556
p.Q1362E	SIDM01117	Small Cell Lung Carcinoma	GDSC	LAPATPALQPIHI	DEG_ODPH_VHL_1	0.3056
p.Q1362E	ACH-002176	Lung Cancer	CCLE	LAPATPALQPIHI	DEG_ODPH_VHL_1	0.3056
p.Q1362E	NCI-H748	lung	COSMIC	LAPATPALQPIHI	DEG_ODPH_VHL_1	0.3056
p.K1341R	SIDM00901	Endometrial Carcinoma	GDSC	LAPATPALQPIHI	DEG_ODPH_VHL_1	0.5556
p.K1341R	ACH-000940	Endometrial/Uterine Cancer	CCLE	LAPATPALQPIHI	DEG_ODPH_VHL_1	0.5556
p.K1341R	AN3-CA	endometrium	COSMIC	LAPATPALQPIHI	DEG_ODPH_VHL_1	0.5556
p.A1347V	SIDM01608	Endometrial Carcinoma	GDSC	LAPATPALQPIHI	DEG_ODPH_VHL_1	0.2778
p.A1347V	ACH-000990	Endometrial/Uterine Cancer	CCLE	LAPATPALQPIHI	DEG_ODPH_VHL_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKJ3	G patch domain-containing protein 8	DEG_ODPH_VHL_1	1349:1361	LAPATPALQPIHI	VHL	0.9632	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPATPALQPIHI

Degron related mutations and impact score

Drug responses associated with GPATCH8 mutations

All proteins holding degron of LAPATPALQPIHI