DegronMD

Uniprot ID: Q96A73

Source protein: Putative monooxygenase p33MONOX

Source gene: KIAA1191

Class: DEG_SCF_TRCP1_1

Location: 235:241

E3 ligase: BTRC

DEGRON score: 0.7744

ASA_SCORE: 55.2143

COIL: 0.6006

CONS_SCORE: 0.6183

DSS_SCORE: 0.4632

HELIX: 0.277

FCONS_SCORE: 0.863

RIG_SCORE: 0.7037

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A247D	DO229031	LICA	ICGC	DSGSFAT	DEG_SCF_TRCP1_1	0.1667
p.A247D	DO229034	LICA	ICGC	DSGSFAT	DEG_SCF_TRCP1_1	0.1667
p.L225V	DO50900	LICA	ICGC	DSGSFAT	DEG_SCF_TRCP1_1	0.0556
p.D235E	DO227567	ORCA	ICGC	DSGSFAT	DEG_SCF_TRCP1_1	0.6758
p.R245Q	SIDM00362	Burkitt's Lymphoma	GDSC	DSGSFAT	DEG_SCF_TRCP1_1	0.2222
p.R245Q	ACH-002293	Lymphoma	CCLE	DSGSFAT	DEG_SCF_TRCP1_1	0.2222
p.R245Q	P32-ISH	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSFAT	DEG_SCF_TRCP1_1	0.2222
p.R226Q	P32-ISH	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSFAT	DEG_SCF_TRCP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96A73	Putative monooxygenase p33MONOX	DEG_SCF_TRCP1_1	235:241	DSGSFAT	BTRC	0.7744	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons