DegronMD - Q96A73(KIAA1191)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A172T	TCGA-19-5956	GBM	TCGA	PSTTPHSS	DEG_SCF_FBW7_1	176:183	Mutation rewiring degron network	0.2222
p.A172T	DO13863	GBM	ICGC	PSTTPHSS	DEG_SCF_FBW7_1	176:183	Mutation rewiring degron network	0.2222
p.P57L	TCGA-66-2758	LUSC	TCGA	PMTPPPS	DEG_SCF_FBW7_1	42:48	Mutation rewiring degron network	0.0833
p.P57L	DO26731	LUSC	ICGC	PMTPPPS	DEG_SCF_FBW7_1	42:48	Mutation rewiring degron network	0.0833
p.T175S	TCGA-B5-A0JR	UCEC	TCGA	PSTTPHSS	DEG_SCF_FBW7_1	176:183	Mutation blocking phosphorylation signal	0.75
p.T175S	DO41791	UCEC	ICGC	PSTTPHSS	DEG_SCF_FBW7_1	176:183	Mutation blocking phosphorylation signal	0.75
p.K56E	TCGA-B5-A3FA	UCEC	TCGA	PMTPPPS	DEG_SCF_FBW7_1	42:48	Mutation substituting flanking lysine	0.2222
p.V53I	TCGA-FI-A2D0	UCEC	TCGA	PMTPPPS	DEG_SCF_FBW7_1	42:48	Mutation rewiring degron network	0.1944
p.V53I	SIDM00845	Burkitt's Lymphoma	GDSC	PMTPPPS	DEG_SCF_FBW7_1	42:48	Mutation rewiring degron network	0.1944
p.A172S	TCGA-JY-A93F	ESCA	TCGA	PSTTPHSS	DEG_SCF_FBW7_1	176:183	Mutation rewiring degron network	0.2222
p.S171L	TCGA-NJ-A4YP	LUAD	TCGA	PSTTPHSS	DEG_SCF_FBW7_1	176:183	Mutation blocking phosphorylation signal	0.6389
p.S171L	DO218943	LUAD	ICGC	PSTTPHSS	DEG_SCF_FBW7_1	176:183	Mutation blocking phosphorylation signal	0.6389
p.A37T	DO9114	COAD	ICGC	PMTPPPS	DEG_SCF_FBW7_1	42:48	Mutation rewiring degron network	0.1944
p.A37T	DO233766	GACA	ICGC	PMTPPPS	DEG_SCF_FBW7_1	42:48	Mutation rewiring degron network	0.1944
p.A41V	DO52450	COCA	ICGC	PMTPPPS	DEG_SCF_FBW7_1	42:48	Mutation rewiring degron network	0.3056
p.A41V	SIDM00596	Endometrial Carcinoma	GDSC	PMTPPPS	DEG_SCF_FBW7_1	42:48	Mutation rewiring degron network	0.3056
p.P45A	DO223032	ESCA	ICGC	PMTPPPS	DEG_SCF_FBW7_1	42:48	Mutation altering degron motif	0.7503
p.A49T	DO16069	HNSC	ICGC	PMTPPPS	DEG_SCF_FBW7_1	42:48	Mutation rewiring degron network	0.3056
p.A49T	DO228138	PBCA	ICGC	PMTPPPS	DEG_SCF_FBW7_1	42:48	Mutation rewiring degron network	0.3056
p.P180Q	DO228948	LICA	ICGC	PSTTPHSS	DEG_SCF_FBW7_1	176:183	Mutation altering degron motif	0.7035
p.A247D	DO229031	LICA	ICGC	DSGSFAT	DEG_SCF_TRCP1_1	235:241	Mutation rewiring degron network	0.1667
p.A247D	DO229034	LICA	ICGC	DSGSFAT	DEG_SCF_TRCP1_1	235:241	Mutation rewiring degron network	0.1667
p.P32T	DO229037	LICA	ICGC	PMTPPPS	DEG_SCF_FBW7_1	42:48	Mutation rewiring degron network	0.0556
p.L225V	DO50900	LICA	ICGC	DSGSFAT	DEG_SCF_TRCP1_1	235:241	Mutation rewiring degron network	0.0556
p.P180L	DO231033	LUSC	ICGC	PSTTPHSS	DEG_SCF_FBW7_1	176:183	Mutation altering degron motif	0.7582
p.D235E	DO227567	ORCA	ICGC	DSGSFAT	DEG_SCF_TRCP1_1	235:241	Mutation altering degron motif	0.6758
p.P35L	DO46838	RECA	ICGC	PMTPPPS	DEG_SCF_FBW7_1	42:48	Mutation rewiring degron network	0.1389
p.K185M	DO46827	RECA	ICGC	PSTTPHSS	DEG_SCF_FBW7_1	176:183	Mutation rewiring degron network	0.2778
p.K37E	DO52402	UCEC	ICGC	PMTPPPS	DEG_SCF_FBW7_1	42:48	Mutation rewiring degron network	0.1944
p.V34I	DO43891	UCEC	ICGC	PMTPPPS	DEG_SCF_FBW7_1	42:48	Mutation rewiring degron network	0.1111
p.P47S	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	PMTPPPS	DEG_SCF_FBW7_1	42:48	Mutation altering degron motif	0.5641
p.P47S	ACH-000693	Esophageal Cancer	CCLE	PMTPPPS	DEG_SCF_FBW7_1	42:48	Mutation altering degron motif	0.5641
p.P47S	KYSE-180	oesophagus	COSMIC	PMTPPPS	DEG_SCF_FBW7_1	42:48	Mutation altering degron motif	0.5641
p.R245Q	SIDM00362	Burkitt's Lymphoma	GDSC	DSGSFAT	DEG_SCF_TRCP1_1	235:241	Mutation rewiring degron network	0.2222
p.R245Q	ACH-002293	Lymphoma	CCLE	DSGSFAT	DEG_SCF_TRCP1_1	235:241	Mutation rewiring degron network	0.2222
p.R245Q	P32-ISH	haematopoietic and lymphoid tissue	COSMIC	DSGSFAT	DEG_SCF_TRCP1_1	235:241	Mutation rewiring degron network	0.2222
p.P188S	SIDM00779	Colorectal Carcinoma	GDSC	PSTTPHSS	DEG_SCF_FBW7_1	176:183	Mutation rewiring degron network	0.1944
p.P188S	ACH-000491	Colon/Colorectal Cancer	CCLE	PSTTPHSS	DEG_SCF_FBW7_1	176:183	Mutation rewiring degron network	0.1944
p.P188S	NCI-H716	large intestine	COSMIC	PSTTPHSS	DEG_SCF_FBW7_1	176:183	Mutation rewiring degron network	0.1944
p.Y33H	SIDM00140	Melanoma	GDSC	PMTPPPS	DEG_SCF_FBW7_1	42:48	Mutation rewiring degron network	0.0833
p.Y33H	ACH-000968	Skin Cancer	CCLE	PMTPPPS	DEG_SCF_FBW7_1	42:48	Mutation rewiring degron network	0.0833
p.Y33H	COLO-792	skin	COSMIC	PMTPPPS	DEG_SCF_FBW7_1	42:48	Mutation rewiring degron network	0.0833
p.D39G	SIDM01217	Other Blood Cancers	GDSC	PMTPPPS	DEG_SCF_FBW7_1	42:48	Mutation rewiring degron network	0.25
p.D39G	ACH-002276	Leukemia	CCLE	PMTPPPS	DEG_SCF_FBW7_1	42:48	Mutation rewiring degron network	0.25
p.D39G	MY-M12	haematopoietic and lymphoid tissue	COSMIC	PMTPPPS	DEG_SCF_FBW7_1	42:48	Mutation rewiring degron network	0.25
p.P54H	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PMTPPPS	DEG_SCF_FBW7_1	42:48	Mutation rewiring degron network	0.1667
p.P54H	ACH-001127	Leukemia	CCLE	PMTPPPS	DEG_SCF_FBW7_1	42:48	Mutation rewiring degron network	0.1667
p.P54H	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PMTPPPS	DEG_SCF_FBW7_1	42:48	Mutation rewiring degron network	0.1667
p.F192V	ACH-000350	Colon/Colorectal Cancer	CCLE	PSTTPHSS	DEG_SCF_FBW7_1	176:183	Mutation rewiring degron network	0.0833
p.F192V	ACH-000450	Skin Cancer	CCLE	PSTTPHSS	DEG_SCF_FBW7_1	176:183	Mutation rewiring degron network	0.0833
p.F192V	ACH-000950	Colon/Colorectal Cancer	CCLE	PSTTPHSS	DEG_SCF_FBW7_1	176:183	Mutation rewiring degron network	0.0833
p.F192V	ACH-000987	Skin Cancer	CCLE	PSTTPHSS	DEG_SCF_FBW7_1	176:183	Mutation rewiring degron network	0.0833
p.F192V	ACH-000997	Colon/Colorectal Cancer	CCLE	PSTTPHSS	DEG_SCF_FBW7_1	176:183	Mutation rewiring degron network	0.0833
p.R226Q	P32-ISH	haematopoietic and lymphoid tissue	COSMIC	DSGSFAT	DEG_SCF_TRCP1_1	235:241	Mutation rewiring degron network	0.0833
p.P41L	SK-MEL-31	skin	COSMIC	PMTPPPS	DEG_SCF_FBW7_1	42:48	Mutation rewiring degron network	0.3056
p.P169S	NCI-H716	large intestine	COSMIC	PSTTPHSS	DEG_SCF_FBW7_1	176:183	Mutation rewiring degron network	0.1389
p.P35H	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PMTPPPS	DEG_SCF_FBW7_1	42:48	Mutation rewiring degron network	0.1389
p.P192H	LNCaP-Clone-FGC	prostate	COSMIC	PSTTPHSS	DEG_SCF_FBW7_1	176:183	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIAA1191

UniProt ID: Q96A73

Entrez ID: 57179

Protein name: Putative monooxygenase p33MONOX (EC 1.-.-.-) (Brain-derived rescue factor p60MONOX) (Flavin monooxygenase motif-containing protein of 33 kDa)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIAA1191 in