DegronMD

Uniprot ID: Q96A73

Source protein: Putative monooxygenase p33MONOX

Source gene: KIAA1191

Class: DEG_SCF_FBW7_1

Location: 42:48

E3 ligase: FBXW7

DEGRON score: 0.7983

ASA_SCORE: 68.5714

COIL: 0.918

CONS_SCORE: 0.8438

DSS_SCORE: 0.6456

HELIX: 0.0541

FCONS_SCORE: 1.0914

RIG_SCORE: 0.6049

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P57L	TCGA-66-2758	LUSC	TCGA	PMTPPPS	DEG_SCF_FBW7_1	0.0833
p.P57L	DO26731	LUSC	ICGC	PMTPPPS	DEG_SCF_FBW7_1	0.0833
p.K56E	TCGA-B5-A3FA	UCEC	TCGA	PMTPPPS	DEG_SCF_FBW7_1	0.2222
p.V53I	TCGA-FI-A2D0	UCEC	TCGA	PMTPPPS	DEG_SCF_FBW7_1	0.1944
p.V53I	SIDM00845	Burkitt's Lymphoma	GDSC	PMTPPPS	DEG_SCF_FBW7_1	0.1944
p.A37T	DO9114	COAD	ICGC	PMTPPPS	DEG_SCF_FBW7_1	0.1944
p.A37T	DO233766	GACA	ICGC	PMTPPPS	DEG_SCF_FBW7_1	0.1944
p.A41V	DO52450	COCA	ICGC	PMTPPPS	DEG_SCF_FBW7_1	0.3056
p.A41V	SIDM00596	Endometrial Carcinoma	GDSC	PMTPPPS	DEG_SCF_FBW7_1	0.3056
p.P45A	DO223032	ESCA	ICGC	PMTPPPS	DEG_SCF_FBW7_1	0.7503
p.A49T	DO16069	HNSC	ICGC	PMTPPPS	DEG_SCF_FBW7_1	0.3056
p.A49T	DO228138	PBCA	ICGC	PMTPPPS	DEG_SCF_FBW7_1	0.3056
p.P32T	DO229037	LICA	ICGC	PMTPPPS	DEG_SCF_FBW7_1	0.0556
p.P35L	DO46838	RECA	ICGC	PMTPPPS	DEG_SCF_FBW7_1	0.1389
p.K37E	DO52402	UCEC	ICGC	PMTPPPS	DEG_SCF_FBW7_1	0.1944
p.V34I	DO43891	UCEC	ICGC	PMTPPPS	DEG_SCF_FBW7_1	0.1111
p.P47S	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	PMTPPPS	DEG_SCF_FBW7_1	0.5641
p.P47S	ACH-000693	Esophageal Cancer	CCLE	PMTPPPS	DEG_SCF_FBW7_1	0.5641
p.P47S	KYSE-180	oesophagus	COSMIC	PMTPPPS	DEG_SCF_FBW7_1	0.5641
p.Y33H	SIDM00140	Melanoma	GDSC	PMTPPPS	DEG_SCF_FBW7_1	0.0833
p.Y33H	ACH-000968	Skin Cancer	CCLE	PMTPPPS	DEG_SCF_FBW7_1	0.0833
p.Y33H	COLO-792	skin	COSMIC	PMTPPPS	DEG_SCF_FBW7_1	0.0833
p.D39G	SIDM01217	Other Blood Cancers	GDSC	PMTPPPS	DEG_SCF_FBW7_1	0.25
p.D39G	ACH-002276	Leukemia	CCLE	PMTPPPS	DEG_SCF_FBW7_1	0.25
p.D39G	MY-M12	haematopoietic_and_lymphoid_tissue	COSMIC	PMTPPPS	DEG_SCF_FBW7_1	0.25
p.P54H	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PMTPPPS	DEG_SCF_FBW7_1	0.1667
p.P54H	ACH-001127	Leukemia	CCLE	PMTPPPS	DEG_SCF_FBW7_1	0.1667
p.P54H	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PMTPPPS	DEG_SCF_FBW7_1	0.1667
p.P41L	SK-MEL-31	skin	COSMIC	PMTPPPS	DEG_SCF_FBW7_1	0.3056
p.P35H	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PMTPPPS	DEG_SCF_FBW7_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PMTPPPS

Degron related mutations and impact score

Drug responses associated with KIAA1191 mutations

All proteins holding degron of PMTPPPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96A73	Putative monooxygenase p33MONOX	DEG_SCF_FBW7_1	42:48	PMTPPPS	FBXW7	0.7983	More...