DegronMD

Uniprot ID: Q96A73

Source protein: Putative monooxygenase p33MONOX

Source gene: KIAA1191

Class: DEG_SCF_FBW7_1

Location: 176:183

E3 ligase: FBXW7

DEGRON score: 0.9974

ASA_SCORE: 77.2

COIL: 0.934

CONS_SCORE: 0.7545

DSS_SCORE: 0.8297

HELIX: 0.0211

FCONS_SCORE: 1.0788

RIG_SCORE: 0.5352

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P180L	DO231033	LUSC	ICGC	PSTTPHSS	DEG_SCF_FBW7_1	0.7582
p.T175S	TCGA-B5-A0JR	UCEC	TCGA	PSTTPHSS	DEG_SCF_FBW7_1	0.75
p.T175S	DO41791	UCEC	ICGC	PSTTPHSS	DEG_SCF_FBW7_1	0.75
p.P180Q	DO228948	LICA	ICGC	PSTTPHSS	DEG_SCF_FBW7_1	0.7035
p.S171L	TCGA-NJ-A4YP	LUAD	TCGA	PSTTPHSS	DEG_SCF_FBW7_1	0.6389
p.S171L	DO218943	LUAD	ICGC	PSTTPHSS	DEG_SCF_FBW7_1	0.6389
p.K185M	DO46827	RECA	ICGC	PSTTPHSS	DEG_SCF_FBW7_1	0.2778
p.A172T	TCGA-19-5956	GBM	TCGA	PSTTPHSS	DEG_SCF_FBW7_1	0.2222
p.A172T	DO13863	GBM	ICGC	PSTTPHSS	DEG_SCF_FBW7_1	0.2222
p.A172S	TCGA-JY-A93F	ESCA	TCGA	PSTTPHSS	DEG_SCF_FBW7_1	0.2222
p.P188S	SIDM00779	Colorectal Carcinoma	GDSC	PSTTPHSS	DEG_SCF_FBW7_1	0.1944
p.P188S	ACH-000491	Colon/Colorectal Cancer	CCLE	PSTTPHSS	DEG_SCF_FBW7_1	0.1944
p.P188S	NCI-H716	large_intestine	COSMIC	PSTTPHSS	DEG_SCF_FBW7_1	0.1944
p.P169S	NCI-H716	large_intestine	COSMIC	PSTTPHSS	DEG_SCF_FBW7_1	0.1389
p.F192V	ACH-000350	Colon/Colorectal Cancer	CCLE	PSTTPHSS	DEG_SCF_FBW7_1	0.0833
p.F192V	ACH-000450	Skin Cancer	CCLE	PSTTPHSS	DEG_SCF_FBW7_1	0.0833
p.F192V	ACH-000950	Colon/Colorectal Cancer	CCLE	PSTTPHSS	DEG_SCF_FBW7_1	0.0833
p.F192V	ACH-000987	Skin Cancer	CCLE	PSTTPHSS	DEG_SCF_FBW7_1	0.0833
p.F192V	ACH-000997	Colon/Colorectal Cancer	CCLE	PSTTPHSS	DEG_SCF_FBW7_1	0.0833
p.P192H	LNCaP-Clone-FGC	prostate	COSMIC	PSTTPHSS	DEG_SCF_FBW7_1	0.0833

Showing 1 to 20 of 20 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96A73	Putative monooxygenase p33MONOX	DEG_SCF_FBW7_1	176:183	PSTTPHSS	FBXW7	0.9974	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons