DegronMD

Uniprot ID: Q12888

Source protein: TP53-binding protein 1

Source gene: TP53BP1

Class: DEG_SCF_TRCP1_1

Location: 35:41

E3 ligase: BTRC

DEGRON score: 0.8621

ASA_SCORE: 80.7857

COIL: 0.7499

CONS_SCORE: 0.3758

DSS_SCORE: 0.5818

HELIX: 0.2259

FCONS_SCORE: 0.9589

RIG_SCORE: 0.6387

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R50Q	TCGA-EO-A22X	UCEC	TCGA	DSGSHFS	DEG_SCF_TRCP1_1	0.0833
p.R45Q	DO43907	UCEC	ICGC	DSGSHFS	DEG_SCF_TRCP1_1	0.2222
p.H44Y	SIDM00789	Colorectal Carcinoma	GDSC	DSGSHFS	DEG_SCF_TRCP1_1	0.25
p.H44Y	SIDM00259	Neuroblastoma	GDSC	DSGSHFS	DEG_SCF_TRCP1_1	0.25
p.H44Y	ACH-000997	Colon/Colorectal Cancer	CCLE	DSGSHFS	DEG_SCF_TRCP1_1	0.25
p.H44Y	ACH-001061	Colon/Colorectal Cancer	CCLE	DSGSHFS	DEG_SCF_TRCP1_1	0.25
p.H44Y	ACH-002278	Neuroblastoma	CCLE	DSGSHFS	DEG_SCF_TRCP1_1	0.25
p.H44Y	NB10	autonomic_ganglia	COSMIC	DSGSHFS	DEG_SCF_TRCP1_1	0.25
p.H44Y	HCT-15	large_intestine	COSMIC	DSGSHFS	DEG_SCF_TRCP1_1	0.25
p.G42C	SIDM00863	Burkitt's Lymphoma	GDSC	DSGSHFS	DEG_SCF_TRCP1_1	0.3056
p.G42C	ACH-000877	Lymphoma	CCLE	DSGSHFS	DEG_SCF_TRCP1_1	0.3056
p.G42C	ACH-001064	Lymphoma	CCLE	DSGSHFS	DEG_SCF_TRCP1_1	0.3056
p.G42C	EB2	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSHFS	DEG_SCF_TRCP1_1	0.3056
p.E33A	SIDM00863	Burkitt's Lymphoma	GDSC	DSGSHFS	DEG_SCF_TRCP1_1	0.2778
p.E33A	ACH-000877	Lymphoma	CCLE	DSGSHFS	DEG_SCF_TRCP1_1	0.2778
p.E33A	ACH-001064	Lymphoma	CCLE	DSGSHFS	DEG_SCF_TRCP1_1	0.2778
p.E33A	EB2	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSHFS	DEG_SCF_TRCP1_1	0.2778
p.H39Y	ACH-001091	Colon/Colorectal Cancer	CCLE	DSGSHFS	DEG_SCF_TRCP1_1	0.6118
p.H39Y	HCT-15	large_intestine	COSMIC	DSGSHFS	DEG_SCF_TRCP1_1	0.6118
p.H39Y	NB10	autonomic_ganglia	COSMIC	DSGSHFS	DEG_SCF_TRCP1_1	0.6118
p.E28A	EB2	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSHFS	DEG_SCF_TRCP1_1	0.1389
p.G37C	EB2	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSHFS	DEG_SCF_TRCP1_1	0.76

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12888	TP53-binding protein 1	DEG_SCF_TRCP1_1	35:41	DSGSHFS	BTRC	0.8621	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons