DegronMD

Uniprot ID: Q9BVN2

Source protein: AP-4 complex accessory subunit RUSC1

Source gene: RUSC1

Class: DEG_SCF_TRCP1_1

Location: 285:290

E3 ligase: BTRC

DEGRON score: 0.9712

ASA_SCORE: 81.8333

COIL: 0.9008

CONS_SCORE: 0.3607

DSS_SCORE: 0.5575

HELIX: 0.044

FCONS_SCORE: 0.8684

RIG_SCORE: 0.6655

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R300I	TCGA-06-5416	GBM	TCGA	DSGSKT	DEG_SCF_TRCP1_1	0.0556
p.R300I	DO10880	GBM	ICGC	DSGSKT	DEG_SCF_TRCP1_1	0.0556
p.D285N	TCGA-98-8021	LUSC	TCGA	DSGSKT	DEG_SCF_TRCP1_1	0.6932
p.D285N	DO27468	LUSC	ICGC	DSGSKT	DEG_SCF_TRCP1_1	0.6932
p.S286C	TCGA-CR-5248	HNSC	TCGA	DSGSKT	DEG_SCF_TRCP1_1	0.7541
p.S286C	DO14694	HNSC	ICGC	DSGSKT	DEG_SCF_TRCP1_1	0.7541
p.R288H	DO51951	BLCA	ICGC	DSGSKT	DEG_SCF_TRCP1_1	0.8244
p.R288H	DO38723	STAD	ICGC	DSGSKT	DEG_SCF_TRCP1_1	0.8244
p.R288H	DO47827	STAD	ICGC	DSGSKT	DEG_SCF_TRCP1_1	0.8244
p.R288H	DO41235	UCEC	ICGC	DSGSKT	DEG_SCF_TRCP1_1	0.8244
p.R288H	DO41361	UCEC	ICGC	DSGSKT	DEG_SCF_TRCP1_1	0.8244
p.S286F	DO225215	BRCA	ICGC	DSGSKT	DEG_SCF_TRCP1_1	0.7982
p.S286F	DO227836	BRCA	ICGC	DSGSKT	DEG_SCF_TRCP1_1	0.7982
p.W299R	DO222877	COCA	ICGC	DSGSKT	DEG_SCF_TRCP1_1	0.0833
p.H289Q	DO46473	OV	ICGC	DSGSKT	DEG_SCF_TRCP1_1	0.7582
p.G287S	ACH-001842	Bile Duct Cancer	CCLE	DSGSKT	DEG_SCF_TRCP1_1	0.6993
p.E295K	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSKT	DEG_SCF_TRCP1_1	0.1944
p.T299A	COLO-684	endometrium	COSMIC	DSGSKT	DEG_SCF_TRCP1_1	0.0833
p.R297Q	NCI-H650	lung	COSMIC	DSGSKT	DEG_SCF_TRCP1_1	0.1389
p.S295R	HCT-15	large_intestine	COSMIC	DSGSKT	DEG_SCF_TRCP1_1	0.1944
p.T281I	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSKT	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BVN2	AP-4 complex accessory subunit RUSC1	DEG_SCF_TRCP1_1	285:290	DSGSKT	BTRC	0.9712	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons