DegronMD - Q9BVN2(RUSC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R300I	TCGA-06-5416	GBM	TCGA	DSGSKT	DEG_SCF_TRCP1_1	285:290	Mutation rewiring degron network	0.0556
p.R300I	DO10880	GBM	ICGC	DSGSKT	DEG_SCF_TRCP1_1	285:290	Mutation rewiring degron network	0.0556
p.N183K	TCGA-55-7574	LUAD	TCGA	TTCQDVPSP	DEG_COP1_1	186:194	Mutation rewiring degron network	0.25
p.N183K	DO23986	LUAD	ICGC	TTCQDVPSP	DEG_COP1_1	186:194	Mutation rewiring degron network	0.25
p.D285N	TCGA-98-8021	LUSC	TCGA	DSGSKT	DEG_SCF_TRCP1_1	285:290	Mutation altering degron motif	0.6932
p.D285N	DO27468	LUSC	ICGC	DSGSKT	DEG_SCF_TRCP1_1	285:290	Mutation altering degron motif	0.6932
p.S275C	TCGA-BT-A20U	BLCA	TCGA	DSGWKT	DEG_SCF_TRCP1_1	274:279	Mutation altering degron motif	0.7541
p.S275C	DO538	BLCA	ICGC	DSGWKT	DEG_SCF_TRCP1_1	274:279	Mutation altering degron motif	0.7541
p.D274G	TCGA-CG-5721	STAD	TCGA	DSGWKT	DEG_SCF_TRCP1_1	274:279	Mutation altering degron motif	0.7198
p.D274G	DO38192	STAD	ICGC	DSGWKT	DEG_SCF_TRCP1_1	274:279	Mutation altering degron motif	0.7198
p.Q189H	TCGA-CQ-5326	HNSC	TCGA	TTCQDVPSP	DEG_COP1_1	186:194	Mutation altering degron motif	0.647
p.Q189H	DO15286	HNSC	ICGC	TTCQDVPSP	DEG_COP1_1	186:194	Mutation altering degron motif	0.647
p.S286C	TCGA-CR-5248	HNSC	TCGA	DSGSKT	DEG_SCF_TRCP1_1	285:290	Mutation altering degron motif	0.7541
p.S286C	DO14694	HNSC	ICGC	DSGSKT	DEG_SCF_TRCP1_1	285:290	Mutation altering degron motif	0.7541
p.P270H	TCGA-D1-A15X	UCEC	TCGA	DSGWKT	DEG_SCF_TRCP1_1	274:279	Mutation rewiring degron network	0.2222
p.P270H	DO43274	UCEC	ICGC	DSGWKT	DEG_SCF_TRCP1_1	274:279	Mutation rewiring degron network	0.2222
p.L178M	TCGA-EO-A3KX	UCEC	TCGA	TTCQDVPSP	DEG_COP1_1	186:194	Mutation rewiring degron network	0.1111
p.L178M	DO219774	UCEC	ICGC	TTCQDVPSP	DEG_COP1_1	186:194	Mutation rewiring degron network	0.1111
p.K267T	TCGA-EY-A1GD	UCEC	TCGA	DSGWKT	DEG_SCF_TRCP1_1	274:279	Mutation substituting flanking lysine	0.25
p.K267T	DO42129	UCEC	ICGC	DSGWKT	DEG_SCF_TRCP1_1	274:279	Mutation substituting flanking lysine	0.25
p.C188R	TCGA-NH-A5IV	COAD	TCGA	TTCQDVPSP	DEG_COP1_1	186:194	Mutation altering degron motif	0.719
p.C188R	DO49095	COAD	ICGC	TTCQDVPSP	DEG_COP1_1	186:194	Mutation altering degron motif	0.719
p.S180L	TCGA-YC-A89H	BLCA	TCGA	TTCQDVPSP	DEG_COP1_1	186:194	Mutation rewiring degron network	0.1667
p.S180L	DO51948	BLCA	ICGC	TTCQDVPSP	DEG_COP1_1	186:194	Mutation rewiring degron network	0.1667
p.R288H	DO51951	BLCA	ICGC	DSGSKT	DEG_SCF_TRCP1_1	285:290	Mutation altering degron motif	0.8244
p.R288H	DO38723	STAD	ICGC	DSGSKT	DEG_SCF_TRCP1_1	285:290	Mutation altering degron motif	0.8244
p.R288H	DO47827	STAD	ICGC	DSGSKT	DEG_SCF_TRCP1_1	285:290	Mutation altering degron motif	0.8244
p.R288H	DO41235	UCEC	ICGC	DSGSKT	DEG_SCF_TRCP1_1	285:290	Mutation altering degron motif	0.8244
p.R288H	DO41361	UCEC	ICGC	DSGSKT	DEG_SCF_TRCP1_1	285:290	Mutation altering degron motif	0.8244
p.S286F	DO225215	BRCA	ICGC	DSGSKT	DEG_SCF_TRCP1_1	285:290	Mutation altering degron motif	0.7982
p.S286F	DO227836	BRCA	ICGC	DSGSKT	DEG_SCF_TRCP1_1	285:290	Mutation altering degron motif	0.7982
p.P176L	DO1076	BRCA	ICGC	TTCQDVPSP	DEG_COP1_1	186:194	Mutation rewiring degron network	0.0556
p.P176S	DO1076	BRCA	ICGC	TTCQDVPSP	DEG_COP1_1	186:194	Mutation rewiring degron network	0.0556
p.W299R	DO222877	COCA	ICGC	DSGSKT	DEG_SCF_TRCP1_1	285:290	Mutation rewiring degron network	0.0833
p.E204K	DO222908	MELA	ICGC	TTCQDVPSP	DEG_COP1_1	186:194	Mutation rewiring degron network	0.0556
p.H289Q	DO46473	OV	ICGC	DSGSKT	DEG_SCF_TRCP1_1	285:290	Mutation altering degron motif	0.7582
p.L178P	SIDM02015	Colorectal Carcinoma	GDSC	TTCQDVPSP	DEG_COP1_1	186:194	Mutation rewiring degron network	0.1111
p.A203T	SIDM00216	Colorectal Carcinoma	GDSC	TTCQDVPSP	DEG_COP1_1	186:194	Mutation rewiring degron network	0.0833
p.A203T	ACH-000989	Colon/Colorectal Cancer	CCLE	TTCQDVPSP	DEG_COP1_1	186:194	Mutation rewiring degron network	0.0833
p.V191L	SIDM00845	Burkitt's Lymphoma	GDSC	TTCQDVPSP	DEG_COP1_1	186:194	Mutation altering degron motif	0.6765
p.S275P	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGWKT	DEG_SCF_TRCP1_1	274:279	Mutation altering degron motif	0.6752
p.S275P	ACH-001498	Lymphoma	CCLE	DSGWKT	DEG_SCF_TRCP1_1	274:279	Mutation altering degron motif	0.6752
p.S275P	Farage	haematopoietic and lymphoid tissue	COSMIC	DSGWKT	DEG_SCF_TRCP1_1	274:279	Mutation altering degron motif	0.6752
p.G287S	ACH-001842	Bile Duct Cancer	CCLE	DSGSKT	DEG_SCF_TRCP1_1	285:290	Mutation altering degron motif	0.6993
p.E295K	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	DSGSKT	DEG_SCF_TRCP1_1	285:290	Mutation rewiring degron network	0.1944
p.T299A	COLO-684	endometrium	COSMIC	DSGSKT	DEG_SCF_TRCP1_1	285:290	Mutation rewiring degron network	0.0833
p.R297Q	NCI-H650	lung	COSMIC	DSGSKT	DEG_SCF_TRCP1_1	285:290	Mutation rewiring degron network	0.1389
p.G264C	CAPAN-1	pancreas	COSMIC	DSGWKT	DEG_SCF_TRCP1_1	274:279	Mutation rewiring degron network	0.0556
p.G197D	SNU-1040	large intestine	COSMIC	TTCQDVPSP	DEG_COP1_1	186:194	Mutation rewiring degron network	0.25
p.F196S	MOG-G-UVW	central nervous system	COSMIC	TTCQDVPSP	DEG_COP1_1	186:194	Mutation rewiring degron network	0.2778
p.R181H	HAL-01	haematopoietic and lymphoid tissue	COSMIC	TTCQDVPSP	DEG_COP1_1	186:194	Mutation rewiring degron network	0.1944
p.Q266L	Ca-Ski	cervix	COSMIC	DSGWKT	DEG_SCF_TRCP1_1	274:279	Mutation rewiring degron network	0.1111
p.S295R	HCT-15	large intestine	COSMIC	DSGSKT	DEG_SCF_TRCP1_1	285:290	Mutation rewiring degron network	0.1944
p.M198T	LS-180	large intestine	COSMIC	TTCQDVPSP	DEG_COP1_1	186:194	Mutation rewiring degron network	0.2222
p.T281I	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	DSGWKT	DEG_SCF_TRCP1_1	274:279	Mutation rewiring degron network	0.2778
p.T281I	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	DSGSKT	DEG_SCF_TRCP1_1	285:290	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RUSC1

UniProt ID: Q9BVN2

Entrez ID: 23623

Protein name: AP-4 complex accessory subunit RUSC1 (New molecule containing SH3 at the carboxy-terminus) (Nesca) (RUN and SH3 domain-containing protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RUSC1 in