DegronMD

Uniprot ID: Q9BVN2

Source protein: AP-4 complex accessory subunit RUSC1

Source gene: RUSC1

Class: DEG_COP1_1

Location: 186:194

E3 ligase: COP1

DEGRON score: 0.9835

ASA_SCORE: 81.3667

COIL: 0.918

CONS_SCORE: 0.4239

DSS_SCORE: 0.5622

HELIX: 0.0571

FCONS_SCORE: 0.9067

RIG_SCORE: 0.6919

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N183K	TCGA-55-7574	LUAD	TCGA	TTCQDVPSP	DEG_COP1_1	0.25
p.N183K	DO23986	LUAD	ICGC	TTCQDVPSP	DEG_COP1_1	0.25
p.Q189H	TCGA-CQ-5326	HNSC	TCGA	TTCQDVPSP	DEG_COP1_1	0.647
p.Q189H	DO15286	HNSC	ICGC	TTCQDVPSP	DEG_COP1_1	0.647
p.L178M	TCGA-EO-A3KX	UCEC	TCGA	TTCQDVPSP	DEG_COP1_1	0.1111
p.L178M	DO219774	UCEC	ICGC	TTCQDVPSP	DEG_COP1_1	0.1111
p.C188R	TCGA-NH-A5IV	COAD	TCGA	TTCQDVPSP	DEG_COP1_1	0.719
p.C188R	DO49095	COAD	ICGC	TTCQDVPSP	DEG_COP1_1	0.719
p.S180L	TCGA-YC-A89H	BLCA	TCGA	TTCQDVPSP	DEG_COP1_1	0.1667
p.S180L	DO51948	BLCA	ICGC	TTCQDVPSP	DEG_COP1_1	0.1667
p.P176L	DO1076	BRCA	ICGC	TTCQDVPSP	DEG_COP1_1	0.0556
p.P176S	DO1076	BRCA	ICGC	TTCQDVPSP	DEG_COP1_1	0.0556
p.E204K	DO222908	MELA	ICGC	TTCQDVPSP	DEG_COP1_1	0.0556
p.L178P	SIDM02015	Colorectal Carcinoma	GDSC	TTCQDVPSP	DEG_COP1_1	0.1111
p.A203T	SIDM00216	Colorectal Carcinoma	GDSC	TTCQDVPSP	DEG_COP1_1	0.0833
p.A203T	ACH-000989	Colon/Colorectal Cancer	CCLE	TTCQDVPSP	DEG_COP1_1	0.0833
p.V191L	SIDM00845	Burkitt's Lymphoma	GDSC	TTCQDVPSP	DEG_COP1_1	0.6765
p.G197D	SNU-1040	large_intestine	COSMIC	TTCQDVPSP	DEG_COP1_1	0.25
p.F196S	MOG-G-UVW	central_nervous_system	COSMIC	TTCQDVPSP	DEG_COP1_1	0.2778
p.R181H	HAL-01	haematopoietic_and_lymphoid_tissue	COSMIC	TTCQDVPSP	DEG_COP1_1	0.1944
p.M198T	LS-180	large_intestine	COSMIC	TTCQDVPSP	DEG_COP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BVN2	AP-4 complex accessory subunit RUSC1	DEG_COP1_1	186:194	TTCQDVPSP	COP1	0.9835	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons